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Kappa free light chains is a valid tool in the diagnostics of MS : A large multicenter study
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Leurs, C. E. (VU University Medical Center. Department of Neurology) ;
Twaalfhoven, Ham (Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry) ;
Lissenberg-Witte, B. I. (Department of Epidemiology and Biostatistics, Amsterdam UMC) ;
van Pesch, V (Department of Neurology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain) ;
Dujmovic, Irena (Clinic of Neurology, Clinical Centre of Serbia, School of Medicine, University of Belgrade) ;
Drulovic, Jelena (Clinic of Neurology, Clinical Centre of Serbia, School of Medicine, University of Belgrade) ;
Castellazzi, M. (Department of Biomedical and Specialty Surgical Sciences, University of Ferrara) ;
Bellini, T. (Department of Biomedical and Specialty Surgical Sciences, University of Ferrara) ;
Pugliatti, M. (Department of Biomedical and Specialty Surgical Sciences, University of Ferrara) ;
Kuhle, Jens (Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedicine, University Hospital Basel) ;
Villar, L. M. (Hospital Ramón y Cajal. Departamento de Inmunologia) ;
Alvarez-Cermeño, José C (Hospital Ramón y Cajal. Departamento de Neurologia) ;
Alvarez-Lafuente, Roberto (Instituto de Investigación Sanitaria San Carlos) ;
Hegen, Harald (Department of Neurology, Medical University of Innsbruck) ;
Deisenhammer, Florian (Department of Neurology, Medical University of Innsbruck) ;
Walchhofer, L. M. (Department of Neurology, Medical University of Innsbruck) ;
Thouvenot, Eric (Hôpital Caremeau, Nîmes. Departement of Neurology) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vécsei, L. (Department of Neurology, University of Szeged) ;
Rajda, C. (Department of Neurology, University of Szeged) ;
Galimberti, Daniela (Multiple Sclerosis Centre, University of Milan) ;
Scarpini, E. (Multiple Sclerosis Centre, University of Milan) ;
Altintas, Ayse (Koc University, School of Medicine, Neurology Department) ;
Rejdak, K. (Department of Neurology, Medical University of Lublin) ;
Frederiksen, J. L. (Department of Neurology, Rigshospitalet Glostrup and University of Copenhagen) ;
Pihl-Jensen, G. (Department of Neurology, Rigshospitalet Glostrup and University of Copenhagen) ;
Jensen, Peh (Danish Multiple Sclerosis Centre, Department of Neurology, Rigshospitalet, University of Copenhagen) ;
Khalil, Michael (Department of Neurology, Medical University of Graz) ;
Voortman, Margarete (Department of Neurology, Medical University of Graz) ;
Fazekas, F. (Department of Neurology, Medical University of Graz) ;
Saiz, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
La Puma, D. (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Vercammen, M. (Department of Laboratory Medicine, AZ Sint-Jan Brugge-Oostende) ;
Vanopdenbosch, L. (Department of Neurology, AZ Sint-Jan Brugge-Oostende) ;
Uitdehaag, BMJ (Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC) ;
Killestein, Joep (Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC) ;
Bridel, C. (Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry) ;
Teunissen, Charlotte E. (Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. [...]
2019 -  10.1177/1352458519845844
Multiple sclerosis, Vol. 26 (may 2019) , p. 912-923
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