Kupfer-type immunological synapses in vivo : Raison D'être of SMAC
Mitxitorena, Izaskun (Universitat Autònoma de Barcelona. Institut de Neurociències)
Saavedra-López, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències)
Barcia, Carlos (Universitat Autònoma de Barcelona. Institut de Neurociències)

Date:	2015
Abstract:	T cells engage with antigen-presenting cells to form immunological synapses. These intimate contacts are characterized by the complex arrangement of molecules at the intercellular interface, which has been described as the supramolecular activation cluster (SMAC). However, due to T cells functioning without SMAC formation and the difficulties of studying these complex arrangements in vivo, its biological importance has been questioned. In light of recent data, we focus this review on the putative functionality of SMACs in T-cell synaptic contacts in vivo and emphasize the therapeutic potential of SMAC manipulation in immune-driven diseases.
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Immunological synapses ; Supramolecular activation cluster ; Glioma ; Viral infection ; Immunotherapy
Published in:	Immunology and Cell Biology, Vol. 93, no. 1 (2015) , p. 51-56, ISSN 0818-9641

DOI: 10.1038/icb.2014.80

Post-print 22 p, 433.8 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles