Prediction of absolute risk of fragility fracture at 10 years in a Spanish population : validation of the WHO FRAX ™ tool in Spain
Azagra Ledesma, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina)
Roca Figueras, Genís (Universitat Autònoma de Barcelona. Departament de Medicina)
Encabo, Gloria (Hospital Universitari Vall d'Hebron)
Prieto-Alhambra, Daniel (Universitat Autònoma de Barcelona. Departament de Medicina)
Aguyé Batista, Amada (Institut Català de la Salut)
Zwart, Marta (Institut Català de la Salut)
Güell Parnau, Sílvia (Institut Català de la Salut)
Puchol, Núria (Institut Català de la Salut)
Gené Tous, Emilio (Universitat Autònoma de Barcelona)
Casado, Enrique (Universitat Autònoma de Barcelona)
Sancho, Pilar (Institut Català de la Salut)
Solà, Sílvia (Hospital Universitari de Bellvitge)
Torán, Pere (Institut Català de la Salut)
Iglesias, Milagros (Institut Català de la Salut)
Sabaté, Victòria (Institut Català de la Salut)
López-Expósito, Francesc (Institut Català de la Salut)
Ortiz, Sergio (Institut Català de la Salut)
Fernandez-Hermida, Yolanda (University of Oxford)
Díez Pérez, Adolfo (Universitat Autònoma de Barcelona. Departament de Medicina)

Data:	2011
Resum:	Age-related bone loss is asymptomatic, and the morbidity of osteoporosis is secondary to the fractures that occur. Common sites of fracture include the spine, hip, forearm and proximal humerus. Fractures at the hip incur the greatest morbidity and mortality and give rise to the highest direct costs for health services. Their incidence increases exponentially with age. Independently changes in population demography, the age - and sex- specific incidence of osteoporotic fractures appears to be increasing in developing and developed countries. This could mean more than double the expected burden of osteoporotic fractures in the next 50 years. To assess the predictive power of the WHO FRAX™ tool to identify the subjects with the highest absolute risk of fragility fracture at 10 years in a Spanish population, a predictive validation study of the tool will be carried out. For this purpose, the participants recruited by 1999 will be assessed. These were referred to scan-DXA Department from primary healthcare centres, non hospital and hospital consultations. Study population: Patients attended in the national health services integrated into a FRIDEX cohort with at least one Dual-energy X-ray absorptiometry (DXA) measurement and one extensive questionnaire related to fracture risk factors. Measurements: At baseline bone mineral density measurement using DXA, clinical fracture risk factors questionnaire, dietary calcium intake assessment, history of previous fractures, and related drugs. Follow up by telephone interview to know fragility fractures in the 10 years with verification in electronic medical records and also to know the number of falls in the last year. The absolute risk of fracture will be estimated using the FRAX™ tool from the official web site. Since more than 10 years ago numerous publications have recognised the importance of other risk factors for new osteoporotic fractures in addition to low BMD. The extension of a method for calculating the risk (probability) of fractures using the FRAX™ tool is foreseeable in Spain and this would justify a study such as this to allow the necessary adjustments in calibration of the parameters included in the logarithmic formula constituted by FRAX™.
Ajuts:	Instituto de Salud Carlos III PI09-90507
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	BMC musculoskeletal disorders, Vol. 12 (january 2011) , p. 30, ISSN 1471-2474

DOI: 10.1186/1471-2474-12-30
PMID: 21272372

9 p, 297.2 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d’Investigació i Innovació Parc Taulí (I3PT)
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