The population-based Barcelona-Asymptomatic Intracranial Atherosclerosis Study (ASIA) : rationale and design
López-Cancio, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Dorado Bouix, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Millán, Mónica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Reverté, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Suñol, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Massuet, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Mataró, María (Universitat de Barcelona. Departament de Psiquiatria i de Psicobiologia Clínica)
Galán, Amparo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Alzamora, M. Teresa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Pera, Guillem (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Torán, Pere (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Arenillas, Juan F.. (Hospital Clínico Universitario de Valladolid)
Universitat Autònoma de Barcelona

Date:	2011
Abstract:	Large-artery intracranial atherosclerosis may be the most frequent cause of ischemic stroke worldwide. Traditional approaches have attempted to target the disease when it is already symptomatic. However, early detection of intracranial atherosclerosis may allow therapeutic intervention while the disease is still asymptomatic. The prevalence and natural history of asymptomatic intracranial atherosclerosis in Caucasians remain unclear. The aims of the Barcelona- AS ymptomatic I ntracranial A therosclerosis (ASIA) study are (1) to determine the prevalence of ASIA in a moderate-high vascular risk population, (2) to study its prognostic impact on the risk of suffering future major ischemic events, and (3) to identify predictors of the development, progression and clinical expression of this condition. Cross-over and cohort, population-based study. A randomly selected representative sample of 1,503 subjects with a mild-moderate-high vascular risk (as defined by a REGICOR score ≥ 5%) and with neither a history of cerebrovascular nor ischemic heart disease will be studied. At baseline, all individuals will undergo extracranial and transcranial Color-Coded Duplex (TCCD) ultrasound examinations to detect presence and severity of extra and intracranial atherosclerosis. Intracranial stenoses will be assessed by magnetic resonance angiography (MRA). Clinical and demographic variables will be recorded and blood samples will be drawn to investigate clinical, biological and genetic factors associated with the presence of ASIA. A long-term clinical and sonographic follow-up will be conducted thereafter to identify predictors of disease progression and of incident vascular events. The Barcelona-ASIA is a population-based study aiming to evaluate the prevalence and clinical importance of asymptomatic intracranial large-artery atherosclerosis in Caucasians. The ASIA project may provide a unique scientific resource to better understand the dynamics of intracranial atherosclerosis from its early stages and to identify new potential therapeutic targets for this condition.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	BMC Neurology, Vol. 11 (february 2011) , p. 22, ISSN 1471-2377

DOI: 10.1186/1471-2377-11-22
PMID: 21329527

9 p, 545.1 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles