Pathobiology and innate immune responses of gallinaceous poultry to clade 2.3.4.4A H5Nx highly pathogenic avian influenza virus infection
Bertran, Kateri (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Pantin-Jackwood, M. J. (U.S. National Poultry Research Center. Exotic and Emerging Avian Viral Diseases Research Unit)
Criado, M. F. (U.S. National Poultry Research Center. Exotic and Emerging Avian Viral Diseases Research Unit)
Lee, D. H. (University of Connecticut. Department of Pathobiology and Veterinary Science)
Balzli, C. L. (Battelle National Biodefense Institute (Estats Units d'Amèrica))
Spackman, E. (U.S. National Poultry Research Center. Exotic and Emerging Avian Viral Diseases Research Unit)
Suarez, D. L. (U.S. National Poultry Research Center. Exotic and Emerging Avian Viral Diseases Research Unit)
Swayne, D. E. (U.S. National Poultry Research Center. Exotic and Emerging Avian Viral Diseases Research Unit)

Date:	2019
Abstract:	In the 2014-2015 Eurasian lineage clade 2. 3. 4. 4A H5 highly pathogenic avian influenza (HPAI) outbreak in the U. S. , backyard flocks with minor gallinaceous poultry and large commercial poultry (chickens and turkeys) operations were affected. The pathogenesis of the first H5N8 and reassortant H5N2 clade 2. 3. 4. 4A HPAI U. S. isolates was investigated in six gallinaceous species: chickens, Japanese quail, Bobwhite quail, Pearl guinea fowl, Chukar partridges, and Ring-necked pheasants. Both viruses caused 80-100% mortality in all species, except for H5N2 virus that caused 60% mortality in chickens. The surviving challenged birds remained uninfected based on lack of clinical disease and lack of seroconversion. Among the infected birds, chickens and Japanese quail in early clinical stages (asymptomatic and listless) lacked histopathologic findings. In contrast, birds of all species in later clinical stages (moribund and dead) had histopathologic lesions and systemic virus replication consistent with HPAI virus infection in gallinaceous poultry. These birds had widespread multifocal areas of necrosis, sometimes with heterophilic or lymphoplasmacytic inflammatory infiltrate, and viral antigen in parenchymal cells of most tissues. In general, lesions and antigen distribution were similar regardless of virus and species. However, endotheliotropism was the most striking difference among species, with only Pearl guinea fowl showing widespread replication of both viruses in endothelial cells of most tissues. The expression of IFN-γand IL-10 in Japanese quail, and IL-6 in chickens, were up-regulated in later clinical stages compared to asymptomatic birds.
Note:	Altres ajuts: CEIRS/HHSN272201400008C
Note:	Altres ajuts: APHIS/60-6040-6-005
Note:	Altres ajuts: DELTA-FLU/58-6040-7-012FN
Note:	Altres ajuts: USDA/ARS/6612-32000- 066-00D
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Grip aviària ; Animals ; Galliformes ; Immunity, Innate ; Influenza A virus ; Influenza in Birds ; Poultry Diseases ; United States
Published in:	Veterinary research, Vol. 50 Núm. 1 (january 2019) , p. 89, ISSN 1297-9716

DOI: 10.1186/s13567-019-0704-5
PMID: 31675983

14 p, 1.8 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Centre de Recerca en Sanitat Animal (CReSA-IRTA)
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