The Drosophila melanogaster Genetic Reference Panel
MacKay, Trudy F. C. (Department of Genetics. North Carolina State University)
Richards, Stephen (Human Genome Sequencing Center. Baylor College of Medicine)
Stone, Eric A. (Department of Genetics. North Carolina State University)
Barbadilla Prados, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Ayroles, Julien F. (Harvard University)
Zhu, Dianhui (Human Genome Sequencing Center. Baylor College of Medicine)
Casillas Viladerrams, Sònia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Han, Yi (Human Genome Sequencing Center. Baylor College of Medicine)
Magwire, Michael M. (Department of Genetics. North Carolina State University)
Cridland, Julie M. (Department of Ecology and Evolutionary Biology. University of California-Irvine)
Richardson, Mark F. (Faculty of Life Sciences. University of Manchester)
Anholt, Robert R. H. (Department of Biology. North Carolina State University)
Barrón Aduriz, Maite Garazi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Bess, Crystal (Human Genome Sequencing Center. Baylor College of Medicine)
Blankenburg, Kerstin Petra (Human Genome Sequencing Center. Baylor College of Medicine)
Carbone, Mary Anna (Department of Genetics. North Carolina State University)
Castellano Esteve, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Chaboub, Lesley (Human Genome Sequencing Center. Baylor College of Medicine)
Duncan, Laura (Department of Genetics. North Carolina State University)
Harris, Zeke (Department of Genetics. North Carolina State University)
Javaid, Mehwish (Human Genome Sequencing Center. Baylor College of Medicine)
Jayaseelan, Joy Christina (Human Genome Sequencing Center. Baylor College of Medicine)
Jhangiani, Shalini N. (Human Genome Sequencing Center. Baylor College of Medicine)
Jordan, Katherine W. (Department of Genetics. North Carolina State University)
Lara, Fremiet (Human Genome Sequencing Center. Baylor College of Medicine)
Lawrence, Faye (Department of Genetics. North Carolina State University)
Lee, Sandra L. (Human Genome Sequencing Center. Baylor College of Medicine)
Librado, Pablo (Universitat de Barcelona. Departament de Genètica)
Linheiro, Raquel S. (Faculty of Life Sciences. University of Manchester)
Lyman, Richard F. (Department of Genetics. North Carolina State University)
MacKey, Aaron J. (Center for Public Health Genomics. University of Virginia)
Munidasa, Mala (Human Genome Sequencing Center. Baylor College of Medicine)
Muzny, Donna Marie (Human Genome Sequencing Center. Baylor College of Medicine)
Nazareth, Lynne (Human Genome Sequencing Center. Baylor College of Medicine)
Newsham, Irene (Human Genome Sequencing Center. Baylor College of Medicine)
Perales, Lora (Human Genome Sequencing Center. Baylor College of Medicine)
Pu, Ling-Ling (Human Genome Sequencing Center. Baylor College of Medicine)
Qu, Carson (Human Genome Sequencing Center. Baylor College of Medicine)
Ràmia Jesús, Miquel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Reid, Jeffrey G. (Human Genome Sequencing Center. Baylor College of Medicine)
Rollmann, Stephanie M. (Department of Biological Sciences. University of Cincinnati)
Rozas, Julio (Universitat de Barcelona. Departament de Genètica)
Saada, Nehad (Human Genome Sequencing Center. Baylor College of Medicine)
Turlapati, Lavanya (Department of Genetics. North Carolina State University)
Worley, Kim C. (Human Genome Sequencing Center. Baylor College of Medicine)
Wu, Yuan-Qing (Human Genome Sequencing Center. Baylor College of Medicine)
Yamamoto, Akihiko (Department of Genetics. North Carolina State University)
Zhu, Yiming (Human Genome Sequencing Center. Baylor College of Medicine)
Bergman, Casey M. (Faculty of Life Sciences. University of Manchester)
Thornton, Kevin R. (Department of Ecology and Evolutionary Biology. University of California-Irvine)
Mittelman, David (Virginia Bioinformatics Institute. Department of Biological Sciences. Virginia Tech)
Gibbs, Richard A. (Human Genome Sequencing Center. Baylor College of Medicine)

Fecha:	2012
Resumen:	A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype-phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype-phenotype mapping using the power of Drosophila genetics.
Ayudas:	Ministerio de Economía y Competitividad BFU 2009-09504
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials i que es distribueixin sota la mateixa llicència que regula l'obra original. Cal que es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Drosophila ; Genetic variation ; Genome-wide association studies ; Genomics
Publicado en:	Nature, Vol. 482, issue 7384 (Feb. 2012) , p. 173-178, ISSN 1476-4687

DOI: 10.1038/nature10811
PMID: 22318601

6 p, 807.2 KB

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