Novel Approaches Towards a Functional Cure of HIV/AIDS
Bailón, Lucía (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida)
Mothe, Beatriz (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida)
Berman, Lance (AELIX Therapeutics)
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Therapeutic approaches towards a functional cure or eradication of HIV have gained renewed momentum upon encouraging data emerging from studies in SIV monkey models and recent results from human clinical studies. However, a multitude of questions remain to be addressed, including how to deal with the latent viral reservoir, how to boost the host immune response to the virus and what the hurdles are to reach relevant viral compartments in the body. Advances have been made especially with regard to identifying agents that can reactivate the latent virus in vivo and boost the cellular and humoral immunity, but it remains largely unclear whether any of these strategies can awaken a sufficiently large fraction of the viral reservoir and whether the boosted immunity can prevent rapid viral replication once antiretroviral treatments are stopped.
Grants:	European Commission. Horizon 2020 681137
Note:	Altres ajuts: The present work was funded in parts by NIH Grant P01-AI131568
Note:	Altres ajuts: NIH/P01-AI131568
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Published in:	Drugs, Vol. 80 (may 2020) , p. 859-868, ISSN 1179-1950

DOI: 10.1007/s40265-020-01322-y
PMID: 32436069

10 p, 586.9 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles