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| Home > Articles > Published articles > Oral Administration of Cannabis and Δ-9-tetrahydrocannabinol (THC) Preparations : |
| Home > Articles > Published articles > Oral Administration of Cannabis and Δ-9-tetrahydrocannabinol (THC) Preparations : |
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (Università Politecnica delle Marche, Ancona) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
| Date: | 2020 |
| Abstract: | Background and objective : Changes in cannabis legalization regimes in several countries have influenced the diversification of cannabis use. There is an ever-increasing number of cannabis forms available, which are gaining popularity for both recreational and therapeutic use. From a therapeutic perspective, oral cannabis containing Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) is a promising route of administration but there is still little information about its pharmacokinetics (PK) effects in humans. The purpose of this systematic review is to provide a general overview of the available PK data on cannabis and THC after oral administration. Materials and Methods : A search of the published literature was conducted using the PubMed database to collect available articles describing the PK data of THC after oral administration in humans. Results : The literature search yielded 363 results, 26 of which met our inclusion criteria. The PK of oral THC has been studied using capsules (including oil content), tablets, baked goods (brownies and cookies), and oil and tea (decoctions). Capsules and tablets, which mainly correspond to pharmaceutical forms, were found to be the oral formulations most commonly studied. Overall, the results reflect the high variability in the THC absorption of oral formulations, with delayed peak plasma concentrations compared to other routes of administration. Conclusions : Oral THC has a highly variable PK profile that differs between formulations, with seemingly higher variability in baked goods and oil forms. Overall, there is limited information available in this field. Therefore, further investigations are required to unravel the unpredictability of oral THC administration to increase the effectiveness and safety of oral formulations in medicinal use. |
| Grants: | Instituto de Salud Carlos III FIS-PI14-00715 Instituto de Salud Carlos III FIS-PI17-01962 Instituto de Salud Carlos III PFIS-FI18-00179 Instituto de Salud Carlos III RD16-0017-0003 Instituto de Salud Carlos III RD16-0017-0010 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-316 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-530 |
| Note: | Altres ajuts: Ministerio de Sanidad, Política Social e Igualdad (Plan Nacional Sobre Drogas-PNSD, 2015I054 and 2019I010). |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Oral cannabis ; Oral THC ; Medical use ; Cannabis edibles ; Pharmacokinetics |
| Published in: | Medicina, Vol. 56 (june 2020) , ISSN 1648-9144 |
