Neurotrophic properties of C-terminal domain of the heavy chain of tetanus toxin on motor neuron diseases
Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Aguilera, José (Universitat Autònoma de Barcelona. Institut de Neurociències)
Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències)
Talbot, Kevin (University of Oxford. Nuffield Department of Clinical Neurosciences)

Date:	2020
Abstract:	The carboxyl-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) exerts a neuroprotective effect in neurodegenerative diseases via the activation of signaling pathways related to neurotrophins, and also through inhibiting apoptotic cell death. Here, we demonstrate that Hc-TeTx preserves motoneurons from chronic excitotoxicity in an in vitro model of amyotrophic lateral sclerosis. Furthermore, we found that PI3-K/Akt pathway, but not p21ras/MAPK pathway, is involved in their beneficial effects under chronic excitotoxicity. Moreover, we corroborate the capacity of the Hc-TeTx to be transported retrogradely into the spinal motor neurons and also its capacity to bind to the motoneuron-like cell line NSC-34. These findings suggest a possible therapeutic tool to improve motoneuron preservation in neurodegenerative diseases such as amyotrophic lateral sclerosis.
Grants:	Ministerio de Ciencia e Innovación SAF2016-80027-R Ministerio de Ciencia e Innovación PID2019-106615RB-I00
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Carboxyl-terminal domain of the heavy chain of tetanus toxin ; Neuroprotection ; Excitotoxicity ; Spinal muscular atrophy ; Amyotrophic lateral sclerosis
Published in:	Toxins, Vol. 12 Núm. 10 (2020) , p. 666, ISSN 2072-6651

DOI: 10.3390/toxins12100666
PMID: 33096857

11 p, 1.5 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles