Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention
Kumru, Hatice (Institut Germans Trias i Pujol. Institut Guttmann)
Flores, África (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Rodríguez-Cañón, María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann)
García, Loreto (Institut Germans Trias i Pujol. Institut Guttmann)
Benito-Penalva, Jesús (Institut Germans Trias i Pujol. Institut Guttmann)
Navarro, X. (Xavier) (Xavier) (Institut Germans Trias i Pujol. Institut Guttmann)
Gerasimenko, Yury (Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40292, USA)
García Alias, Guillermo (Institut Germans Trias i Pujol. Institut Guttmann)
Vidal, Joan (Institut Germans Trias i Pujol. Institut Guttmann)

Date:	2021
Abstract:	Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation is a non-invasive method that can modify the functional state of the sensory-motor system. We hypothesize that eEmc delivery, together with hand training, improves hand function in healthy subjects more than either intervention alone by inducing plastic changes at spinal and cortical levels. Ten voluntary participants were included in the following three interventions: (i) hand grip training, (ii) eEmc, and (iii) eEmc with hand training. Functional evaluation included the box and blocks test (BBT) and hand grip maximum voluntary contraction (MVC), spinal and cortical motor evoked potential (sMEP and cMEP), and resting motor thresholds (RMT), short interval intracortical inhibition (SICI), and F wave in the abductor pollicis brevis muscle. eEmc combined with hand training retained MVC and increased F wave amplitude and persistency, reduced cortical RMT and facilitated cMEP amplitude. In contrast, eEmc alone only increased F wave amplitude, whereas hand training alone reduced MVC and increased cortical RMT and SICI. In conclusion, eEmc combined with hand grip training enhanced hand motor output and induced plastic changes at spinal and cortical level in healthy subjects when compared to either intervention alone. These data suggest that electrical neuromodulation changes spinal and, perhaps, supraspinal networks to a more malleable state, while a concomitant use-dependent mechanism drives these networks to a higher functional state.
Grants:	Instituto de Salud Carlos III PI19-01680 European Commission H2020-ERA-NET-NEURON/AC16-00034
Note:	Altres ajuts: Fundació La Marató de TV3 2017 (201713.31) to G.G.-A.; Premi Beca "Mike Lane" 2019-Castellers de la Vila de Gràcia to H.K.; and National Institutes of Health Grant 1R01 NS102920-01A1 to Y.G.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Transcutaneous spinal cord stimulation ; Hand training ; Combined intervention ; Neuromodulation ; Cervical spinal cord
Published in:	Journal of clinical medicine, Vol. 10 (january 2021) , ISSN 2077-0383

DOI: 10.3390/jcm10020195
PMID: 33430460

18 p, 4.3 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles