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| Pàgina inicial > Articles > Articles publicats > Less sedentary time is associated with a more favourable glucose-insulin axis in obese pregnant women-a secondary analysis of the DALI study |
(Medical University of Graz. Department of Obstetrics and Gynaecology) (Medical University of Graz. Department of Obstetrics and Gynaecology) (Lawson Health Research Institute) (Universitat Autònoma de Barcelona. Departament de Medicina) (Western Sydney University. Macarthur Clinical School) (Medical University of Vienna) (Medical University of Vienna) (National University of Ireland. Galway Diabetes Research Centre and College of Medicine Nursing and Health Sciences) (University Hospitals Leuven (Bèlgica)) (Poznan University of Medical Sciences. Division of Reproduction) (Poznan University of Medical Sciences) (Universita Degli Studi di Padova) (Azienda Ospedaliero Universitaria Pisana) (University Medical Centre Rotterdam. Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC) (Institut d'Investigació Biomèdica Sant Pau) (University of Southern Denmark. Department of Clinical Research, Faculty of Health Sciences) (University of Copenhagen. Department of Clinical Medicine, Faculty of Health and Medical Sciences) (Amsterdam UMC. University Medical Center) (University of Graz. Institute of Sport Science)
| Data: | 2020 |
| Resum: | Obese pregnant women are at high risk of developing gestational diabetes mellitus (GDM), which might be reduced by sufficient physical activity (PA) and reduced sedentary time (ST). We assessed whether PA and ST are longitudinally associated with the glucose-insulin axis in obese pregnant women. In this secondary analysis of the DALI (vitamin D And Lifestyle Intervention for gestational diabetes mellitus prevention) study, pregnant women, <20 weeks gestation, with a pre-pregnancy body mass index (BMI) ≥ 29 kg/m 2, without GDM on entry were included. Time spent in moderate-to-vigorous PA (MVPA) and ST were measured objectively with accelerometers at < 20 weeks, 24-28 weeks and 35-37 weeks of gestation. Fasting glucose (mmol/l) and insulin (mU/l), insulin resistance (HOMA-IR) and first-phase and second-phase insulin release (Stumvoll first and second phase) were assessed at the same time. Linear mixed regression models were used to calculate between-participant differences and within-participant changes over time. Analyses were adjusted for gestational age, randomisation, pre-pregnancy BMI, education and age. MVPA, Insulin, HOMA-IR and Stumvoll first and second phase were log-transformed for analyses due to skewness. 232 women were included in the analysis. Concerning differences between participants, more ST was associated with higher fasting glucose (Estimate: 0. 008; 95% CI: 0. 002, 0. 014), fasting insulin (0. 011; 0. 002, 0. 019), HOMA-IR (0. 012; 0. 004, 0. 021) and Stumvoll first and second phase (0. 008; 0. 001, 0. 014 and 0. 007; 0. 001, 0. 014). Participants with more MVPA had lower Stumvoll first and second phase (−0. 137; −0. 210, −0. 064 and −0. 133; −0. 202, −0. 063). Concerning changes over time, an increase in ST during gestation was associated with elevated Stumvoll first and second phase (0. 006; 0. 000, 0. 011). As the glucose-insulin axis is more strongly associated with ST than MVPA in our obese population, pregnant women could be advised to reduce ST in addition to increasing MVPA. Moreover, our findings suggest that behaviour change interventions aiming at GDM risk reduction should start in early or pre-pregnancy. |
| Ajuts: | European Commission 242187 |
| Nota: | Altres ajuts: In Spain, additional funding was provided by CAIBER 1527-B-226. |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Obesity ; Gestational diabetes ; Lifestyle modification |
| Publicat a: | International Journal of Obesity, Vol. 45 (july 2020) , p. 296-307, ISSN 1476-5497 |
