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Pàgina inicial > Articles > Articles publicats > Autobiographical memory and default mode network function in schizophrenia : |
Data: | 2021 |
Resum: | The brain functional correlates of autobiographical recall are well established, but have been little studied in schizophrenia. Additionally, autobiographical memory is one of a small number of cognitive tasks that activates rather than de-activates the default mode network, which has been found to be dysfunctional in this disorder. Twenty-seven schizophrenic patients and 30 healthy controls underwent functional magnetic resonance imaging while viewing cue words that evoked autobiographical memories. Control conditions included both non-memory-evoking cues and a low level baseline (cross fixation). Compared to both non-memory evoking cues and low level baseline, autobiographical recall was associated with activation in default mode network regions in the controls including the medial frontal cortex, the posterior cingulate cortex and the hippocampus, as well as other areas. Clusters of de-activation were seen outside the default mode network. There were no activation differences between the schizophrenic patients and the controls, but the patients showed clusters of failure of de-activation in non-default mode network regions. According to this study, patients with schizophrenia show intact activation of the default mode network and other regions associated with recall of autobiographical memories. The finding of failure of de-activation outside the network suggests that schizophrenia may be associated with a general difficulty in de-activation rather than dysfunction of the default mode network per se. |
Ajuts: | Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-1271 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-1265 Ministerio de Ciencia e Innovación FJCI-2015-25278 Ministerio de Ciencia e Innovación FFI2016-77647-C2-2-P Instituto de Salud Carlos III MSII16-00018 Instituto de Salud Carlos III CM15-00024 Instituto de Salud Carlos III PI18-00877 Instituto de Salud Carlos III PI18-00880 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Autobiographical memory ; Default mode network ; FMRI ; Schizophrenia |
Publicat a: | Psychological Medicine, Vol. 51 (january 2021) , p. 121-128, ISSN 1469-8978 |
8 p, 491.1 KB |