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Pàgina inicial > Articles > Articles publicats > Identification of strong candidate genes for backfat and intramuscular fatty acid composition in three crosses based on the Iberian pig |
Data: | 2020 |
Resum: | Meat quality has an important genetic component and can be modified by the fatty acid (FA) composition and the amount of fat contained in adipose tissue and muscle. The present study aimed to find genomic regions associated with the FA composition in backfat and muscle (longissimus dorsi) in 439 pigs with three different genetic backgrounds but having the Iberian breed in common. Genome-wide association studies (GWAS) were performed between 38,424 single-nucleotide polymorphisms (SNPs) covering the pig genome and 60 phenotypic traits related to backfat and muscle FA composition. Nine significant associated regions were found in backfat on the Sus scrofa chromosomes (SSC): SSC1, SSC2, SSC4, SSC6, SSC8, SSC10, SSC12, and SSC16. For the intramuscular fat, six significant associated regions were identified on SSC4, SSC13, SSC14, and SSC17. A total of 52 candidate genes were proposed to explain the variation in backfat and muscle FA composition traits. GWAS were also reanalysed including SNPs on five candidate genes (ELOVL6, ELOVL7, FADS2, FASN, and SCD). Regions and molecular markers described in our study may be useful for meat quality selection of commercial pig breeds, although several polymorphisms were breed-specific, and further analysis would be needed to evaluate possible causal mutations. |
Ajuts: | Ministerio de Economía y Competitividad AGL2014-56369-C2 Ministerio de Economía y Competitividad AGL2017-82641-R Agència de Gestió d'Ajuts Universitaris i de Recerca ECO/1788/2014 Ministerio de Economía y Competitividad AGL2014-56369-C2 Agència de Gestió d'Ajuts Universitaris i de Recerca ECO/1639/2013 Ministerio de Economía y Competitividad RYC-2013-12573 Ministerio de Economía y Competitividad SEV-2015-0533 |
Nota: | Altres ajuts: CERCA Programme/Generalitat de Catalunya |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Adipose Tissue ; Animal Husbandry ; Animals ; Biomarkers ; Breeding ; Fatty Acids ; Genome-Wide Association Study ; Genomics ; Genotype ; Meat ; Muscles ; Phenotype ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Sus scrofa ; Swine |
Publicat a: | Scientific reports, Vol. 10 (August 2020) , art. 13962, ISSN 2045-2322 |
17 p, 2.7 MB |