Incidence of Recurrent High-Grade Anal Dysplasia in HIV-1-Infected Men and Women Following Infrared Coagulation Ablation : A Retrospective Cohort Study
Corral, Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Parés, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Garcia Cuyàs, Francesc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Revollo, Boris (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Chamorro, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Lecumberri, Carla (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Tarrats, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Castellà Fernández, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Piñol Pascual, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Videla, Sebastià (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Sirera, Guillem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	This single-center, retrospective cohort study sought to estimate the cumulative incidence in HIV-1-infected patients of biopsy-proven high-grade anal intraepithelial neoplasia (HGAIN) recurrence after infrared coagulation (IRC) treatment. The study was based on data from a prospectively compiled database of 665 HIV-1-infected outpatients who attended a hospital Clinical Proctology/HIV Unit between January 2012 and December 2015. Patient records were checked to see which ones had received IRC treatment but later experienced a recurrence of HGAIN. Cytology samples were also checked for the presence of human papilloma virus (HPV). A total of 81 of the 665 patients (12%, 95%CI: 10-15%), of whom 65 were men and 16 women, were diagnosed with HGAIN and again treated with IRC. Of these 81, 20 (25%) experienced recurrent HGAIN, this incidence being true of both men (16/65, 95%CI: 19-57%) and women (4/16, 95%CI: 10-50%). The median time to recurrence was 6 (2-19) months overall, 6 (2-19) months in men, and 4 (2-6) months in women. HPV infection was detected in all patients except two, with HPV-16 being the most common genotype. This rate of incidence of recurrent HGAIN following IRC treatment is consistent with other reports and highlights the importance of continued post-treatment surveillance, particularly in the first year.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Anal dysplasia ; Infrared coagulation ; High-resolution anoscopy ; HIV infection ; Anal intraepithelial neoplasia
Published in:	Pathogens, Vol. 10 (february 2021) , ISSN 2076-0817

DOI: 10.3390/pathogens10020208
PMID: 33672969

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles