Effect of Aging, Gender and Sensory Stimulation of TRPV1 Receptors with Capsaicin on Spontaneous Swallowing Frequency in Patients with Oropharyngeal Dysphagia : A Proof-of-Concept Study
Nascimento, Weslania Viviane (Hospital de Mataró. Consorci Sanitari del Maresme)
Tomsen, Noemí (Universitat Autònoma de Barcelona. Institut de Neurociències)
Acedo, Saray (Universitat de Barcelona. Facultat de Biologia)
Campos Alcantara, Cristina (Universitat de Barcelona. Facultat de Biologia)
Cabib, Christopher (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Alvarez-Larruy, Marta (Hospital de Mataró. Consorci Sanitari del Maresme)
Clavé i Civit, Pere (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)

Date:	2021
Abstract:	Spontaneous swallowing contributes to airway protection and depends on the activation of brainstem reflex circuits in the central pattern generator (CPG). We studied the effect of age and gender on spontaneous swallowing frequency (SSF) in healthy volunteers and assessed basal SSF and TRPV1 stimulation effect on SSF in patients with post-stroke oropharyngeal dysphagia (OD). The effect of age and gender on SSF was examined on 141 healthy adult volunteers (HV) divided into three groups: GI-18-39 yr, GII-40-59 yr, and GIII->60 yr. OD was assessed by the Volume-Viscosity Swallowing Test (VVST). The effect of sensory stimulation with capsaicin 10 −5 M (TRPV1 agonist) was evaluated in 17 patients with post-stroke OD, using the SSF. SSF was recorded in all participants during 10 min using surface electromyography (sEMG) of the suprahyoid muscles and an omnidirectional accelerometer placed over the cricothyroid cartilage. SSF was significantly reduced in GII (0. 73 ± 0. 50 swallows/min; p = 0. 0385) and GIII (0. 50 ± 0. 31 swallows/min; p < 0. 0001) compared to GI (1. 03 ± 0. 62 swallows/min), and there was a moderate significant correlation between age and SFF (r = −0. 3810; p < 0. 0001). No effect of gender on SSF was observed. Capsaicin caused a strong and significant increase in SSF after the TRPV1 stimulation when comparing to basal condition (pre-capsaicin: 0. 41 ± 0. 32 swallows/min vs post-capsaicin: 0. 81 ± 0. 51 swallow/min; p = 0. 0003). OD in patients with post-stroke OD and acute stimulation with TRPV1 agonists caused a significant increase in SSF, further suggesting the potential role of pharmacological stimulation of sensory pathways as a therapeutic strategy for CPG activation in patients with OD.
Grants:	Instituto de Salud Carlos III EHD16PI02 Instituto de Salud Carlos III PI18/00241 Instituto de Salud Carlos III ICI20/00117
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Disorders ; Spontaneous swallowing frequency ; Capsaicin ; TRPV Cation Channels ; Stroke ; Aging
Published in:	Diagnostics, Vol. 11 (march 2021) , ISSN 2075-4418

DOI: 10.3390/diagnostics11030461
PMID: 33799960

12 p, 1.7 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles