Daidzein modulates cocaine-reinforcing effects and cue-induced cocaine reinstatement in CD-1 male mice
Martin, Miquel (Universitat Pompeu Fabra. Parc de Recerca Biomèdica de Barcelona)
Gutiérrez-Martos, Miriam (Universitat Pompeu Fabra. Parc de Recerca Biomèdica de Barcelona)
Cabrera, Roberto (Universitat Pompeu Fabra. Parc de Recerca Biomèdica de Barcelona)
Langohr, Klaus (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa)
Maldonado, Rafael 1961- (Universitat Pompeu Fabra)
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
De La Torre, Rafael (Universitat Pompeu Fabra)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Cocaine addiction is a chronic relapsing disorder that lacks of an effective treatment. Isoflavones are a family of compounds present in different plants and vegetables like soybeans that share a common chemical structure. Previous studies have described that synthetic derivatives from the natural isoflavone daidzin can modulate cocaine addiction, by a mechanism suggested to involve aldehyde-dehydrogenase (ALDH) activities. Based on these previous studies, we investigated the effects of three natural isoflavones, daidzin, daidzein, and genistein, on the modulation of the cocaine reinforcing effects and on cue-induced reinstatement in an operant mouse model of cocaine self-administration. Chronic treatment with daidzein or genistein decreased operant responding to obtain cocaine intravenous infusions. On the other hand, daidzein and daidzin, but not genistein, were effective in decreasing cue-induced cocaine reinstatement. Complementary studies revealed that daidzein effects on cocaine reinforcement were mediated through a mechanism that involved dopamine type-2/3 receptors (DA-D2/3) activities. Our results suggest that these natural compounds alone or in combination can be a potential therapeutic approach for cocaine addiction. Further clinical studies are required in order to ascertain their potential therapeutic use.
Grants:	Instituto de Salud Carlos III RD16/0017/0020 Instituto de Salud Carlos III RD16/0017/0003 Ministerio de Sanidad y Política Social EC10-166 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-669 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SRG-316 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-138
Note:	Altres ajuts: We acknowledge the financial support of the Spanish "Instituto de Salud Carlos III" (#CIBEROBN to R. dl T.), the Catalan Government (#TECCIT2014 and 2015-NeuroPhar to R.M., and #TECCIT2014 and 2015-BAPP to R dl T.). M.M. was a "Beatriu de Pinós" fellow (#2010-BP-B00221). Partial support of FEDER funds is also acknowledged.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cocaine ; Daidzein ; Daidzin ; Dopamine receptors ; Genistein ; Isoflavones ; Reinstatement ; Reinforcing ; Self-administration
Published in:	Psychopharmacology, Vol. 238 (april 2021) , p. 1923-1936, ISSN 1432-2072

DOI: 10.1007/s00213-021-05820-z
PMID: 33839903

14 p, 1.2 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles