Antitumour activity of coordination polymer nanoparticles
Suárez García, Salvio (Institut Català de Nanociència i Nanotecnologia)
Solorzano Rodríguez, Ruben (Institut Català de Nanociència i Nanotecnologia)
Alibes, Ramón (Universitat Autònoma de Barcelona. Departament de Química)
Busqué Sánchez, Félix (Universitat Autònoma de Barcelona. Departament de Química)
Novio Vázquez, Fernando (Universitat Autònoma de Barcelona. Departament de Química)
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)

Data:	2021
Resum:	Nanoscale coordination polymers (NCPs) have fascinated researchers over the last years. Their intrinsic theranostic properties of metal ions and organic ligands, the encapsulation of several drugs/biomolecules with excellent yields and the surface functionalisation, enhancing their biocompatibility and targeting, have remarkably impacted in prospective drug delivery alternatives in medicine. Moreover, the properties and characteristics of these nanoparticles (NPs) can be fine-tuned thanks to the synthetic flexibility of coordination chemistry. For all these reasons, the number of examples published has grown exponentially over the last years, embracing different disciplines such as molecular electronics, sensors or nanomedicine, among others. Specifically, significant advances in antitumoural applications are reported, one of the areas where this novel family of NPs has experienced a considerable advance. NCPs have accomplished a high sophistication degree and efficiency as theranostic nanoplatforms (i. e. , drug delivery carriers and bioimaging probes) with long residence time in the bloodstream, targeting capacities and remarkable cellular internalisation. In this review, an introduction emphasizing the advantages of NPs for cancer treatment is included. Later on, the most representative examples of NCPs for antitumoural applications are described grouped into six mean representative areas: i) encapsulation approaches, ii) stimuli-responsive NCPs, iii) metal chemotherapy, iv) photodynamic therapy (PDT), v) unconventional therapeutic approaches and vi) theranostics. Particular emphasis is given to understand the encapsulation/release properties of these particles at the nanoscale and their interaction with biological environments, highlighting any limitation and challenges that these systems are facing from a clinical translation perspective and envisioning possible future trends and areas that will deserve further attention for the following years.
Ajuts:	Agencia Estatal de Investigación PID2019-106403RB-I00 Agencia Estatal de Investigación RTI2018-098027-B-C21 Agencia Estatal de Investigación RED2018-102471-T Agencia Estatal de Investigación SEV-2017-0706 Ministerio de Economía y Competitividad BES-2015-071492 Ministerio de Educación, Cultura y Deporte FPU14/03170
Nota:	Altres ajuts: the ICN2 is funded by the CERCA programme / Generalitat de Catalunya.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Multifunctional nanoparticle ; Coordination polymer ; TheranosticCancer therapy
Publicat a:	Coordination chemistry reviews, Vol. 441 (Aug. 2021) , art. 213977, ISSN 0010-8545

DOI: 10.1016/j.ccr.2021.213977

24 p, 6.9 MB

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