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| Home > Articles > Published articles > Article targeting pro-oxidant iron with deferoxamine as a treatment for ischemic stroke : |
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) (Hospital Universitari de Girona Doctor Josep Trueta) (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
| Date: | 2021 |
| Abstract: | A role of iron as a target to prevent stroke-induced neurodegeneration has been recently revisited due to new evidence showing that ferroptosis inhibitors are protective in experimental ischemic stroke and might be therapeutic in other neurodegenerative brain pathologies. Ferroptosis is a new form of programmed cell death attributed to an overwhelming lipidic peroxidation due to excessive free iron and reactive oxygen species (ROS). This study aims to evaluate the safety and tolerability and to explore the therapeutic efficacy of the iron chelator and antioxidant deferoxamine mesylate (DFO) in ischemic stroke patients. Administration of placebo or a single DFO bolus followed by a 72 h continuous infusion of three escalating doses was initiated during the tPA infusion, and the impact on blood transferrin iron was determined. Primary endpoint was safety and tolerability, and secondary endpoint was good clinical outcome (clinicalTrials. gov NCT00777140). DFO was found safe as adverse effects were not different between placebo and DFO arms. DFO (40-60 mg/Kg/day) reduced the iron saturation of blood transferrin. A trend to efficacy was observed in patients with moderate-severe ischemic stroke (NIHSS > 7) treated with DFO 40-60 mg/Kg/day. A good outcome was observed at day 90 in 31% of placebo vs. 50-58% of the 40-60 mg/Kg/day DFO-treated patients. |
| Grants: | Ministerio de Economía y Competitividad RD16/0019/0020 Instituto de Salud Carlos III 2007-006731-31 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR1520 Agència de Gestió d'Ajuts Universitaris i de Recerca 2019PROD00120 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Iron ; Deferoxamine ; Antioxidant ; Ferroptosis ; Neuroprotection ; Outcome |
| Published in: | Antioxidants, Vol. 10, p. 1270, ISSN 2076-3921 |
