Mortality trends in an ambulatory multidisciplinary heart failure unit from 2001 to 2018
Spitaleri, Giosafat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Lupón, Josep (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Domingo, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Santiago Vacas, Evelyn (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Codina, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Zamora, Elisabet (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Cediel, Germán (Universitat Autònoma de Barcelona. Departament de Medicina)
Santesmases, Javier (Universitat Autònoma de Barcelona. Departament de Medicina)
Diez-Quevedo, Crisanto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Troya, Maria Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Boldo Alcaine, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Altmir, Salvador (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
González Fernández, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Núñez, Julio (Universitat de València. Departament de Medicina)
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Date:	2021
Abstract:	To assess mortality trends at 1 and 3 years from 2001 to 2018 in a real-life cohort of HF outpatients from different etiologies with depressed and preserved LVEF. A total of 2368 consecutive patients with HF (mean age 66. 4 ± 12. 9 years, 71% men, 15. 4% with preserved LVEF) admitted to a HF clinic from August 2001 to September 2018 were included in the study. Patients were divided into five quintiles (Q) according to the period of admission. Trends for all-cause and cardiovascular mortality from Q1 to Q5 were assessed by linear regression. Patients with LVEF < 50% had a progressive decrease in the rates of all-cause and cardiovascular death at 1 year (12. 1% in Q1 to 6. 5% in Q5, p = 0. 003; and 8. 4% in Q1 to 3. 8% in Q5, p = 0. 007, respectively) and 3 years (30. 5% in Q1 to 17. 0% in Q5, p = 0. 003; and 23. 9% in Q1 to 9. 8% in Q5, p = 0. 003, respectively). These trends remained significant after adjusting for clinical characteristics and risk. No significant trend in mortality was observed in patients with LVEF ≥ 50%. In a cohort of real-life ambulatory patients with HF, mortality progressively declined in patients with LVEF < 50%, but the same trend was not observed in patients with preserved LVEF.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cardiology ; Heart failure
Published in:	Scientific reports, Vol. 11 (january 2021) , ISSN 2045-2322

DOI: 10.1038/s41598-020-79926-3
PMID: 33436787

10 p, 1.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles