Immunological Pattern in IgA Nephropathy
Esteve Cols, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Graterol Torres, Freddzia-Amanda (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Quirant, Bibiana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Marco Rusiñol, Helena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Navarro Díaz, Maruja Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ara del Rey, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)

Date:	2020
Abstract:	The current gold-standard diagnostic technique for IgA nephropathy (IgAN), the leading form of primary glomerulonephritis, is renal biopsy. CD89 (the main IgA receptor) is expressed on the surface of monocytes and plays a role in disease pathogenesis. Immunocomplexes formed by sCD89 (soluble form) and Gd-IgA1 are related to disease prognosis. We hypothesize that reduced CD89 surface expression on monocytes may be a marker of disease severity. We aimed to analyze leukocyte subpopulations in peripheral blood and CD89 surface expression on monocytes in a prospective study of 22 patients and 12 healthy subjects (HS). Leukocyte subpopulations and CD89 expression were analyzed by flow cytometry. IgAN patients had a higher percentage of activated and effector memory CD4 + and CD8 + T lymphocytes, a lower percentage of transitional B lymphocytes and plasmablasts, and a higher percentage of CD56 dim CD16 + NK cells and myeloid dendritic cells compared with HS. Correlations between reduced CD89 expression levels on nonclassical monocytes, histological findings of a poor prognosis on renal biopsy and baseline renal function were observed. IgAN patients show a characteristic immunological pattern in peripheral blood. A reduced expression level of CD89 on nonclassical monocytes identifies patients with a worse renal prognosis.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	IgA Nephropathy ; Monocytes ; CD89 ; Biomarkers
Published in:	International journal of molecular sciences, Vol. 21 (february 2020) , ISSN 1422-0067

DOI: 10.3390/ijms21041389
PMID: 32085673

13 p, 2.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles