The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia
Gröschel, Matthias I. (University Medical Center Groningen. Department of Pulmonary Diseases & Tuberculosis)
Meehan, Conor J. (University of Bradford. School of Chemistry and Bioscience)
Barilar, Ivan (Research Center Borstel. Molecular and Experimental Mycobacteriology)
Diricks, Margo (BioMérieux)
Gonzaga, Aitor (Leibniz Institute DSMZ. German Collection of Microorganisms and Cell Cultures)
Steglich, Matthias (Leibniz Institute DSMZ. German Collection of Microorganisms and Cell Cultures)
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Scherer, Isabell-Christin (Universitätsklinikum Schleswig-Holstein (Alemanya))
Mamat, Uwe (Cellular Microbiology, Research Center Borstel)
Luz, Christian F. (University Medical Center Groningen. Department of Medical Microbiology and Infection Prevention)
De Bruyne, Katrien (bioMérieux, Applied Maths NV)
Utpatel, Christian (Research Center Borstel. Molecular and Experimental Mycobacteriology)
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Kampmeier, Stefanie (University Hospital of Münster (Alemanya))
Rahman, Nurdyana Abdul (Singapore General Hospital. Department of Microbiology)
Kresken, Michael (Rheinische Fachhochschule Köln gGmbH)
van der Werf, Tjip S. (University Medical Center Groningen. Department of Pulmonary Diseases & Tuberculosis)
Alio, Ifey (University of Hamburg. Department of Microbiology and Biotechnology)
Streit, Wolfgang R. (University of Hamburg. Department of Microbiology and Biotechnology)
Zhou, Kai (Jinan University. Second Clinical Medical College)
Schwartz, Thomas (Karlsruhe Institute of Technology)
Rossen, John W. A. (University Medical Center Groningen. Department of Medical Microbiology and Infection Prevention)
Farhat, Maha R. (Massachusetts General Hospital (Boston))
Schaible, Ulrich E. (Leibniz Research Alliance Infections'21)
Nübel, Ulrich (Technical University. Braunschweig Integrated Center of Systems Biology)
Rupp, Jan (German Center for Infection Research)
Steinmann, Joerg (Paracelsus Medical Private University)
Niemann, Stefan (Leibniz Research Alliance Infections'21)
Kohl, Thomas A. (German Center for Infection Research)

Date:	2020
Abstract:	Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals. Multidrug resistance of the opportunistic pathogen Stenotrophomonas maltophilia is an increasing problem. Here, analyzing strains from 22 countries, the authors show that the S. maltophilia complex is divided into 23 monophyletic lineages and find evidence for intra-hospital transmission.
Grants:	European Commission 713660 Ministerio de Economía y Competitividad BIO2015-66674-R European Commission 643476
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Bacteriology ; Pathogens ; Epidemiology
Published in:	Nature communications, Vol. 11 (April 2020) , art. 2044, ISSN 2041-1723

DOI: 10.1038/s41467-020-15123-0
PMID: 32341346

12 p, 2.3 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
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