2026-03-23
21:12 |
|
2026-03-16
10:13 |
|
14 p, 7.9 MB |
Conjugation strategy shapes antitumor efficacy and enables dose-sparing in non-antibody protein nanoconjugates
/
Rueda, Ariana (Institut de Recerca Sant Pau) ;
Garcia León, Annabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Arena, Lourdes Ailen (Institut de Recerca Sant Pau) ;
Mendoza, Julian Ignacio (Institut de Recerca Sant Pau) ;
Aviñó, Ana (Institut de Química Avançada de Catalunya) ;
Fabrega, Carme (Institut de Química Avançada de Catalunya) ;
Eritja, Ramon (Institut de Química Avançada de Catalunya) ;
Paez, David (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Alba Castellón, Lorena (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mangues, Ramon 1957- (Institut de Recerca Sant Pau) ;
Casanova Rigat, Isolda (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Unzueta Elorza, Ugutz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Precision targeting is a hot topic in cancer nanomedicine, as conventional chemotherapies cause systemic toxicities, creating an urgent need for more selective treatments. Although antibody-drug conjugates (ADCs) are the current gold standard in targeted therapy, their clinical performance remains limited. [...]
2026 -  10.1016/j.mtbio.2025.102698
Materials Today Bio, Vol. 36 (February 2026) , art. 102698
|
|
2026-03-05
16:16 |
|
2026-03-27
12:13 |
|
11 p, 1.6 MB |
Lactic Acid Influences Iron Assimilation by a Fungal Pathogen via the Iron Reductive Uptake Pathway
/
Gomes-Gonçalves, Alexandra (Universidade do Minho) ;
Van Genechten, Wouter (Katholieke Universiteit te Leuven (1970- )) ;
Ataíde, Patrícia (Universidade do Minho) ;
Barata-Antunes, Cláudia (Universidade do Minho) ;
Ghasemi, Faezeh (Universidade do Minho) ;
Casal, Margarida (Universidade do Minho) ;
Teixeira, Miguel C. (Universidade de Lisboa) ;
Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Brown, Alistair J. P. (University of Exeter) ;
Van Dijck, Patrick (Katholieke Universiteit te Leuven (1970- )) ;
Paiva, Sandra (Universidade do Minho) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Candida albicans is a fungal commensal of humans that often causes mucosal infections in otherwise healthy individuals and also serious infections in immunocompromised patients. The capacity of this fungus to colonize and cause disease relies on its ability to grow within the host, adapting to various nutrient restrictions and physicochemical conditions. [...]
2025 - 10.1002/mbo3.70167
MicrobiologyOpen, Vol. 14, Num. 6 (December 2025) , art. e70167
|
|
2026-03-12
19:12 |
|
18 p, 4.6 MB |
HLA-DRB1 Allelic Combinations Differentially Shape Dendritic Cell Antigen Presentation Enhanced by Tumour Cell Line Lysate-Pulsing
/
Lázaro, Gonzalo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cedano, Juan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Faus, Maitane (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Roura-Mir, Carme (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Garrigós Cubells, Laia (Centre Internacional de Càncer de Mama. Barcelona) ;
Pérez-García, José (Medical Scientia Innovation Research (MedSIR)) ;
Román-García, Javier (Universidad Europea de Madrid) ;
Cortés Castán, Javier (Medical Scientia Innovation Research (MedSIR)) ;
Aran, Andrea (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Martí, Mercè (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
The anti-tumour immune response plays a pivotal role in eliminating tumour cells, with the presence of tumour-infiltrating lymphocytes (TILs) often correlated with improved patient outcomes. Among these, CD4+ T lymphocytes act as key orchestrators of the immune response, functioning as effector and regulatory cells, and are essential for establishing immunological memory. [...]
2026 - 10.1111/tan.70563
HLA: Immune Response Genetics, Vol. 107, Num. 2 (February 2026) , art. e70563
|
|
2026-03-05
08:14 |
|
9 p, 3.1 MB |
Biotin-specific molecularly imprinted polymers as a biomimetic test line in lateral flow assays
/
Marfà, Jennifer (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Valle, Anaixis del (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Rovatti Pupin, Rafael (Universidade Estadual Paulista "Júlio de Mesquita Filho". Departamento de Química Analítica) ;
Baró Sastre, Barbara (Institut de Salut Global de Barcelona) ;
Bassat, Quique (Hospital Clínic i Provincial de Barcelona) ;
Taboada Sotomayor, Maria Del Pilar (Universidade Estadual Paulista "Júlio de Mesquita Filho". Departamento de Química Analítica) ;
Pividori, María Isabel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Lateral flow assays are widely used for rapid diagnostics at the point of care. However, their dependence on biological receptors limits their stability, scalability, and cost-effectiveness. This work demonstrates the use of biotin-specific molecularly imprinted polymers (biotin-MIPs) as synthetic recognition elements in nucleic acid lateral flow (NALF) assays. [...]
2026 - 10.1016/j.bios.2026.118415
Biosensors & bioelectronics, Vol. 298 (April 2026) , art. 118415
|
|
2026-02-26
19:12 |
|
19 p, 3.6 MB |
Preparation of cell-derived vesicles from eukaryotic and prokaryotic origins for the delivery of biomolecules
/
Atienza-Garriga, Jan (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Smithers, Luke (The University of Western Australia) ;
Cooper, Crystal (The University of Western Australia) ;
Vrielink, Alice (The University of Western Australia) ;
Ferrer-Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Cell membrane-derived vesicles play essential roles in intercellular communication, material transport, and waste disposal. Despite their biomedical and industrial potential, isolating extracellular vesicles from natural sources remains technically challenging, limiting purification efficiency and scalability. [...]
2026 - 10.1080/21691401.2025.2599072
Artificial Cells, Nanomedicine and Biotechnology, Vol. 54, Num. 1 (January 2026) , p. 1-18
|
|
2026-03-05
08:14 |
|
9 p, 3.6 MB |
Competitive magneto enzyme-linked miRNA assay for quantification of microRNAs in exosomes
/
Bernuz, Mireia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Martí, Mercè (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Pividori, María Isabel (Universitat Autònoma de Barcelona. Departament de Química)
MicroRNAs (miRNAs) are non-coding, short RNA sequences involved in gene regulation. Although intracellular molecules, miRNAs are also found in biological fluids, where they serve as promising diagnostic and prognostic biomarkers. [...]
2026 - 10.1016/j.talanta.2026.129431
Talanta, Vol. 302 (May 2026) , art. 129431
|
|
2026-03-05
08:14 |
|
12 p, 3.4 MB |
AGGRESCAN and its evolution : A two-decade perspective on protein aggregation prediction
/
Pesce, Giulia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Solé Pozas, Josep Oriol (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bárcenas, Oriol (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Ventura, Salvador (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Protein aggregation is a widespread phenomenon with profound biological, biomedical, and biotechnological implications. In human disease, aberrant protein self-assembly is a hallmark of numerous neurodegenerative disorders, whereas in the biopharmaceutical industry, aggregation complicates the production, stability, and formulation of therapeutic proteins. [...]
2026 - 10.1007/s12551-025-01404-9
Biophysical Reviews, January 2026
|
|
2026-02-25
18:12 |
|
11 p, 8.1 MB |
Subcutaneous administration of an endocrine-mimetic platform allows for prolonged tumor uptake of a tumor targeting protein
/
Álamo, Patricia (Institut de Recerca Sant Pau) ;
López-Laguna, Hèctor (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
de Pinho Favaro, Marianna T. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gallardo, Alberto (Institut de Recerca Sant Pau) ;
Alba Castellón, Lorena (Institut de Recerca Sant Pau) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mangues, Ramon 1957- (Institut de Recerca Sant Pau) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Endocrine-like dynamic protein depots can be fabricated in vitro through the coordination of divalent zinc ions (Zn) with solvent-exposed histidine residues on functional proteins, leading to their controlled aggregation. [...]
2026 - 10.1016/j.ijpharm.2026.126585
International journal of pharmaceutics, Vol. 690 (February 2026) , art. 126585
|
|
|
|
guest ::
Usage statistics
Most popular
