Institut de Biotecnologia i de Biomedicina (IBB)

The Institut de Biotecnologia i de Biomedicina (IBB) was created in 1970 as a research institute of the Universitat Autònoma de Barcelona (UAB). Although the institute was originally devoted to promoting fundamental biological research, we have been focusing in the Biotechnology and Biomedicine fields for the last 20 years.

At the IBB we conduct top-level scientific research with the aim of advancing scientific findings into translational results, to revert our knowledge to society. Our researchers participate in high competitive calls, both national and internationally, aimed at funding basic and translational research.

Among the over 200 researchers currently working at the IBB, there are lecturers and professors from the UAB, ICREA and other senior researchers, postdoctoral fellows, and PhD and Master students. The IBB hosts 18 research groups organised into 3 programmes covering different areas of scientific expertise that include bioinformatics, cellular and structural biology, genomics, immunology, microbiology and proteomics.

Our multidisciplinary character, one of the most relevant characteristics of the IBB, allows for a broad approach to biological problems, both basic and applied. The IBB researchers have expertise in several topics within the biomedicine and the biotechnology field.

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Latest additions:
2024-06-18
05:56
11 p, 3.8 MB LysJEP8 : A promising novel endolysin for combating multidrug-resistant Gram-negative bacteria / Carratalá, José Vicente (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ferrer-Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Garcia-Fruitos, Elena (Institut de Recerca i Tecnologia Agroalimentàries) ; Arís i Giralt, Anna (Institut de Recerca i Tecnologia Agroalimentàries)
Antimicrobial resistance (AMR) is an escalating global health crisis, driven by the overuse and misuse of antibiotics. Multidrug-resistant Gram-negative bacteria, such as Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae, are particularly concerning due to their high morbidity and mortality rates. [...]
2024 - 10.1111/1751-7915.14483
Microbial Biotechnology, Vol. 17, Issue 6 (June 2024) , art. e14483  
2024-06-12
08:31
11 p, 1.9 MB Structural Stabilization of Clinically Oriented Oligomeric Proteins During their Transit through Synthetic Secretory Amyloids / Sanchez, Julieta M (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; López-Laguna, Hèctor (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Parladé, Eloi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Di Somma, Angela (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Livieri, Andrea (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Álamo, Patricia (Institut de Recerca Sant Pau) ; Mangues, Ramón (Institut de Recerca Sant Pau) ; Unzueta Elorza, Ugutz (Institut de Recerca Sant Pau) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Vázquez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Developing time-sustained drug delivery systems is a main goal in innovative medicines. Inspired by the architecture of secretory granules from the mammalian endocrine system it has generated non-toxic microscale amyloid materials through the coordination between divalent metals and poly-histidine stretches. [...]
2024 - 10.1002/advs.202309427
Advanced science, Vol. 11 Núm. 21 (may 2024) , p. 2309427  
2024-06-07
00:28
10 p, 3.7 MB Metal-Organic Framework-Based Antimicrobial Touch Surfaces to Prevent Cross-Contamination / Fonseca, Javier (Universitat Autònoma de Barcelona. Departament de Química) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Cortés, Pilar (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Saldo, Jordi (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Montpeyó, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Lorenzo, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Llagostera, Montserrat (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Imaz, Inhar (Institut Català de Nanociència i Nanotecnologia) ; Maspoch, Daniel (Universitat Autònoma de Barcelona. Departament de Química)
Infection diseases are a major threat to global public health, with nosocomial infections being of particular concern. In this context, antimicrobial coatings emerge as a promising prophylactic strategy to reduce the transmission of pathogens and control infections. [...]
2024 - 10.1002/adma.202403813
Advanced materials, (May 2024) , art 2403813  
2024-06-05
01:54
11 p, 4.8 MB An α-helical peptide-based plasmonic biosensor for highly specific detection of α-synuclein toxic oligomers / Giarola, Juliana Fátima (Institut Català de Nanociència i Nanotecnologia) ; Santos, Jaime (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Estévez, M. Carmen (Institut Català de Nanociència i Nanotecnologia) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Background: α-Synuclein (αS) aggregation is the main neurological hallmark of a group of neurodegenerative disorders, collectively referred to as synucleinopathies, of which Parkinson's disease (PD) is the most prevalent. [...]
2024 - 10.1016/j.aca.2024.342559
Analytica chimica acta, Vol. 1304 (May 2024) , art. 342559  
2024-05-14
13:00
10 p, 10.4 MB A Targetable N-Terminal Motif Orchestrates α-Synuclein Oligomer-to-Fibril Conversion / Santos, Jaime (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Cuellar, Jorge (Centro Nacional de Biotecnología) ; Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Byrd, Emily (University of Leeds) ; Lends, Alons (Université de Bordeaux) ; Moro, Fernando (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular) ; Abdul-Shukkoor, Muhammed Bilal (Université de Bordeaux) ; Pujols, Jordi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Velasco-Carneros, Lorea (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular) ; Sobott, Frank (University of Leeds) ; Otzen, Daniel E. (Aarhus University) ; Calabrese, Antonio N. (University of Leeds) ; Muga, Arturo (Universidad del País Vasco. Departamento de Bioquímica y Biología Molecular) ; Pedersen, Jan Skov (Aarhus University) ; Loquet, Antoine (Université de Bordeaux) ; Valpuesta, Jose María (Centro Nacional de Biotecnología) ; Radford, Sheena E. (University of Leeds) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Oligomeric species populated during α-synuclein aggregation are considered key drivers of neurodegeneration in Parkinson's disease. However, the development of oligomer-targeting therapeutics is constrained by our limited knowledge of their structure and the molecular determinants driving their conversion to fibrils. [...]
2024 - 10.1021/jacs.4c02262
Journal of the American Chemical Society, Vol. 146, Issue 18 (May 2024) , p. 12702−12711  
2024-05-14
04:01
8 p, 1.9 MB Construction and validation of a gene expression classifier to predict immunotherapy response in primary triple-negative breast cancer / Ensenyat Méndez, Miquel (Institut d'Investigació Sanitària Illes Balears) ; Orozco, Javier I. J. (Providence Saint John's Health Center) ; Llinàs-Arias, Pere (Institut d'Investigació Sanitària Illes Balears) ; Íñiguez-Muñoz, Sandra (Institut d'Investigació Sanitària Illes Balears) ; Baker, Jennifer L. (David Geffen School of Medicine at UCLA. Department of Surgery) ; Salomon, Matthew P. (University of Southern California (USC). Department of Medicine) ; Martí, Mercè (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; DiNome, Maggie L. (Duke University School of Medicine. Department of Surgery) ; Cortés, Javier (Universidad Europea de Madrid. Departamento de Medicina) ; Marzese, Diego (Institut d'Investigació Sanitària Illes Balears) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
Immune checkpoint inhibitors (ICI) improve clinical outcomes in triple-negative breast cancer (TNBC) patients. However, a subset of patients does not respond to treatment. Biomarkers that show ICI predictive potential in other solid tumors, such as levels of PD-L1 and the tumor mutational burden, among others, show a modest predictive performance in patients with TNBC. [...]
2023 - 10.1038/s43856-023-00311-y
Communications Medicine, Vol. 3 (July 2023) , art. 93  
2024-05-03
12:13
3 p, 664.6 KB Revelen el paper crucial de l'ARNm en el control i resposta de tumors en la cèl·lula / Karakostis, Konstantinos (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Un estudi pioner de la UAB revela el paper fonamental de les estructures secundàries de l'ARNm codificant en la maquinària de detecció de danys a l'ADN, que dirigeix i estabilitza les proteïnes vitals en la resposta al dany genètic, com la p53. [...]
Un estudio pionero de la UAB revela el papel fundamental de las estructuras secundarias del ARNm codificante en la maquinaria de detección de daños al ADN, que dirige y estabiliza las proteínas vitales en la respuesta al daño genético, como la p53. [...]
A pioneering UAB study reveals the fundamental role of secondary structures of encoding mRNA in the DNA damage detection machinery, which directs and stabilizes vital proteins in the response to genetic damage, such as p53. [...]

2024
UAB divulga, Abril 2024, p. 1-2
3 documents
2024-04-27
08:57
8 p, 4.5 MB Peptide-based biosensing approaches for targeting breast cancer-derived exosomes / da Fonseca Alves, Rafael (Universitat Autònoma de Barcelona. Departament de Química) ; Pallarès-Rusiñol, Arnau (Universitat Autònoma de Barcelona. Departament de Química) ; Rossi, Rosanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Martí, Mercè (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Rezende Vaz, Emilia (Universidade Estadual Paulista) ; Gonçalves de Araújo, Thaise (Universidade Federal de Uberlândia) ; Sotomayor, Maria (Universidade Federal de Uberlândia) ; Pividori, María Isabel (Universitat Autònoma de Barcelona. Departament de Química)
Exosomes are nanovesicles present in all the biological fluids, making them attractive as non-invasive biomarkers for diseases like cancer, among many others. However, exosomes are complex to separate and detect, requiring comprehensive molecular characterization for their routine use in diagnostics. [...]
2024 - 10.1016/j.bios.2024.116211
Biosensors & bioelectronics, Vol. 255 (July 2024) , art. 116211  
2024-04-23
06:32
6 p, 589.2 KB Los exosomas : nuevas herramientas para el diagnóstico de enfermedades no transmisibles en biopsias líquidas / Rossi, Rosanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pallarès-Rusiñol, Arnau (Universitat Autònoma de Barcelona. Departament de Química) ; Martí, Mercè (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pividori, María Isabel (Universitat Autònoma de Barcelona. Departament de Química)
2024
Actualidad Analítica, Vol. 85 (2024) , p. 15-20  
2024-04-06
09:32
15 p, 6.5 MB Harnessing alkaline-pH regulatable promoters for efficient methanol-free expression of enzymes of industrial interest in Komagataella phaffii / Albacar, Marcel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Casamayor Gracia, Antonio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Background The yeast Komagataella phaffii has become a very popular host for heterologous protein expression, very often based on the use of the AOX1 promoter, which becomes activated when cells are grown with methanol as a carbon source. [...]
2024 - 10.1186/s12934-024-02362-9
Microbial cell factories, Vol. 23 (April 2024) , art. 99