2024-09-06
12:14 |
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15 p, 11.8 MB |
The pluripotency state of human embryonic stem cells derived from single blastomeres of eight-cell embryos
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Massafret Surinyach, Ot (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Barragán, Montserrat (Parc Científic de Barcelona) ;
Álvarez-González, Lucía (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Aran, Begoña (Institut d'Investigació Biomèdica de Bellvitge) ;
Martín-Mur, Beatriz (Centre de Regulació Genòmica) ;
Esteve-Codina, Anna (Universitat Pompeu Fabra) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ibáñez, Elena (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Santaló, Josep (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Human embryonic stem cells (hESCs) derived from blastocyst stage embryos present a primed state of pluripotency, whereas mouse ESCs (mESCs) display naïve pluripotency. Their unique characteristics make naïve hESCs more suitable for particular applications in biomedical research. [...]
2024 -  10.1016/j.cdev.2024.203935
Cells and Development, Vol. 179 (September 2024) , art. 203935
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2024-09-06
12:14 |
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18 p, 5.5 MB |
The Mla system and its role in maintaining outer membrane barrier function in Stenotrophomonas maltophilia
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Coves, Xavier (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mamat, Uwe (Leibniz Lung Center) ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Huedo Moreno, Pol (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Bravo, Marc (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Krohn, Ines (University Institute of Plant Science and Microbiology of Hamburg. Department of Microbiology and Biotechnology) ;
Streit, Wolfgang R. (University Institute of Plant Science and Microbiology of Hamburg. Department of Microbiology and Biotechnology) ;
Schaible, Ulrich E. (Leibniz Lung Center) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero, Danel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Stenotrophomonas maltophilia are ubiquitous Gram-negative bacteria found in both natural and clinical environments. It is a remarkably adaptable species capable of thriving in various environments, thanks to the plasticity of its genome and a diverse array of genes that encode a wide range of functions. [...]
2024 - 10.3389/fcimb.2024.1346565
Frontiers in cellular and infection microbiology, Vol. 14 (February 2024) , art. 1346565
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2024-09-06
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2024-09-06
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2024-09-06
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14 p, 7.5 MB |
Lyophilization of biomimetic amyloids preserves their regulatable, endocrine-like functions for nanoparticle release
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de Pinho Favaro, Marianna T (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
López-Laguna, Hèctor (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Voltà-Durán, Eric (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Alba-Castellón, Lorena (Institut de Recerca Sant Pau) ;
Sánchez, Julieta M. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Casanova, Isolda (Institut de Recerca Sant Pau) ;
Unzueta Elorza, Ugutz (Institut de Recerca Sant Pau) ;
Mangues, Ramon 1957- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The secretory granules from the mammalian endocrine system are functional amyloids that act as dynamic depots to store and release protein hormones into the bloodstream. The controlled in vitro coordination between divalent cations and solvent-exposed histidine residues triggers reversible, cross-molecular interactions that result in granular protein aggregates with protein-leaking properties. [...]
2024 - 10.1016/j.apmt.2024.102348
Applied materials today, Vol. 39 (August 2024) , art. 102348
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2024-09-06
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7 p, 5.1 MB |
Incomplete transcriptional dosage compensation of chicken and platypus sex chromosomes is balanced by post-transcriptional compensation
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Lister, Nicholas (University of New South Wales Sydney) ;
Milton, Ashley M. (University of New South Wales Sydney) ;
Patel, Hardip R. (Australian National University) ;
Waters, Shafagh A. (University of New South Wales) ;
Hanrahan, Benjamin J. (University of New South Wales Sydney) ;
McIntyre, Kim L. (University of New South Wales Sydney) ;
Livernois, Alexandra M. (Zymeworks) ;
Horspool, William B. (University of New South Wales Sydney) ;
Wee, Lee Kian (University of New South Wales Sydney) ;
Ringel, Alessa R. (Institute of Chemistry and Biochemistry. Freie Universität Berlin) ;
Mundlos, Stefan (CharitéUniversitätsmedizin Berlin) ;
Robson, Michael I. (University of Edinburgh) ;
Shearwin-Whyatt, Linda (University of Adelaide) ;
Grutzner, Frank (School of Biological Sciences. University of Adelaide) ;
Marshall Graves, Jennifer A. (Institute of Applied Ecology. University of Canberra) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cellular, Fisiologia I Immunologia) ;
Waters, Paul D. (School of Biotechnology and Biomolecular Sciences. Faculty of Science. University of New South Wales Sydney) ;
Universitat Autònoma de Barcelona.
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Heteromorphic sex chromosomes (XY or ZW) present problems of gene dosage imbalance between sexes and with autosomes. A need for dosage compensation has long been thought to be critical in vertebrates. [...]
2024 - 10.1073/pnas.2322360121
Proceedings of the National Academy of Sciences of the United States of America, Vol. 121, Issue 32 (July 2024) , art. e2322360121
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2024-09-06
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16 p, 1.4 MB |
Multiple Genomic Landscapes of Recombination and Genomic Divergence in Wild Populations of House Mice-The Role of Chromosomal Fusions and Prdm9
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Marín-García, Cristina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Álvarez-González, Lucía (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Marin Gual, Laia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Casillas Viladerrams, Sònia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Picón, Judith (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yam, Keren (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Garcias-Ramis, Maria Magdalena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vara González, Covadonga (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Ventura Queija, Jacinto (Universitat Autònoma de Barcelona. Departament de Biologia Animal, Biologia Vegetal i Ecologia) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Chromosomal fusions represent one of the most common types of chromosomal rearrangements found in nature. Yet, their role in shaping the genomic landscape of recombination and hence genome evolution remains largely unexplored. [...]
2024 - 10.1093/molbev/msae063
Molecular biology and evolution, Vol. 41, Issue 4 (April 2024) , art. msae063
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2024-09-06
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9 p, 5.3 MB |
Paradoxical cell targeting of calreticulin-empowered, protein-only nanoparticles
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Parladé Molist, Eloi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
García-Leon, Annabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Voltà-Durán, Eric (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Unzueta Elorza, Ugutz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mangues, Ramon 1957- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Casanova Rigat, Isolda (Institut de Recerca Sant Pau) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Surface-exposed calreticulin (CRT) serves as a crucial cell damage-associated molecular pattern for immunogenic apoptosis, by generating an "eat me" signal to macrophages. Aiming at precision immunotherapies we intended to artificially label tumoral cells in vivo with a recombinant CRT, in a targeted way. [...]
2024 - 10.1016/j.ejpb.2024.114410
European Journal of Pharmaceutics and Biopharmaceutics, Vol. 202 (September 2024) , art. 114410
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2024-09-06
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30 p, 4.9 MB |
Extant and extinct bilby genomes combined with Indigenous knowledge improve conservation of a unique Australian marsupial
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Hogg, Carolyn J. (The University of Sydney) ;
Edwards, Richard J. (School of Biotechnology and Biomolecular Sciences) ;
Farquharson, Katherine A. (The University of Sydney) ;
Silver, Luke W. (The University of Sydney) ;
Brandies, Parice (The University of Sydney) ;
Peel, Emma (The University of Sydney) ;
Escalona, Merly (University of California Santa Cruz) ;
Jaya, Frederick R. (The University of Sydney) ;
Thavornkanlapachai, Rujiporn (Biodiversity and Conservation Science) ;
Batley, Kimberley (The University of Sydney) ;
Bradford, Tessa M. (The University of Adelaide) ;
Chang, J. King (School of Biotechnology and Biomolecular Sciences) ;
Chen, Zhiliang (Illumina) ;
Deshpande, Nandan (School of Biotechnology and Biomolecular Science) ;
Dziminski, Martin (Biodiversity and Conservation Science) ;
Ewart, Kyle M. (The University of Sydney) ;
Griffith, Oliver W. (Macquarie University) ;
Marin Gual, Laia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Moon, Katherine L. (University of California Santa Cruz) ;
Travouillon, Kenny J. (Western Australian Museum) ;
Waters, Paul D (School of Biotechnology and Biomolecular Sciences) ;
Whittington, Camilla M. (The University of Sydney) ;
Wilkins, Marc R. (School of Biotechnology and Biomolecular Science. UNSW) ;
Helgen, Kristofer M. (Australian Museum Research Institute) ;
Lo, Nathan (The University of Sydney) ;
Ho, Simon Y.W. (The University of Sydney) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Paltridge, Rachel (Kiwirrkura Community) ;
Marshall Graves, Jennifer A. (La Trobe University) ;
Renfree, Marilyn B (University of Melbourne) ;
Shapiro, Beth (University of California Santa Cruz) ;
Ottewell, Kym (Biodiversity and Conservation Science) ;
Belov, Katherine (ARC The University of Sydney) ;
Gibson, Conway (Kiwirrkura Community) ;
Maxwell, Raymond (Kiwirrkura Community) ;
Spencer, Zecharia (Kiwirrkura Community) ;
Napangati, Yalti (Kiwirrkura Community) ;
Butler, Mary (Kiwirrkura Community) ;
West, Janine (Kiwirrkura Community) ;
West, John (Kiwirrkura Community) ;
James, Mantua (Kiwirrkura Community) ;
Napangati, Nolia (Kiwirrkura Community) ;
Gibson, Loretta (Kiwirrkura Community) ;
West, Payu (Kiwirrkura Community) ;
Gibson, Angus (Kiwirrkura Community) ;
West, Scott (Kiwirrkura Community) ;
West, Kim (Kiwirrkura Community) ;
Japaltjari, Walimpirri (Kiwirrkura Community) ;
Blackwood, Ed (Kiwirrkura Community) ;
Paltridge, Rachel (Kiwirrkura Community)
Ninu (greater bilby, Macrotis lagotis) are desert-dwelling, culturally and ecologically important marsupials. In collaboration with Indigenous rangers and conservation managers, we generated the Ninu chromosome-level genome assembly (3. [...]
2024 - 10.1038/s41559-024-02436-2
Nature ecology & evolution, Vol. 8 (July 2024) , p. 1311-1326
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2024-09-06
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74 p, 25.1 MB |
Three-dimensional genome architecture persists in a 52,000-year-old woolly mammoth skin sample
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Sandoval-Velasco, Marcela (University of Copenhagen) ;
Dudchenko, Olga (Rice University) ;
Rodríguez, Juan Antonio (Centre Nacional d'Anàlisi Genòmica) ;
Pérez Estrada, Cynthia (Rice University) ;
Dehasque, Marianne (Stockholm University) ;
Fontsere, Claudia (University of Copenhagen) ;
Mak, Sarah S.T. (University of Copenhagen) ;
Khan, Ruqayya (Baylor College of Medicine) ;
Contessoto, Vinícius G. (Rice University) ;
Oliveira Junior, Antonio B. (Rice University) ;
Kalluchi, Achyuth (University of Nebraska Medical Center) ;
Zubillaga Herrera, Bernardo (Northeastern University) ;
Jeong, Jiyun (Baylor College of Medicine) ;
Roy, Renata P. (Texas Southern University) ;
Christopher, Ishawnia (Baylor College of Medicine) ;
Weisz, David (The Baylor College of Medicine) ;
Omer, Arina D. (Baylor College of Medicine) ;
Batra, Sanjit S. (Baylor College of Medicine) ;
Shamim, Muhammad S. (Baylor College of Medicine) ;
Durand, Neva C. (Broad Institute of MIT and Harvard) ;
O'Connell, Brendan (Oregon Health & Science University) ;
Roca, Alfred L. (University of Illinois at Urbana-Champaign) ;
Plikus, Maksim V. (University of California. Irvine) ;
Kusliy, Mariya A. (Institute of Molecular and Cellular Biology SB RAS) ;
Romanenko, Svetlana A. (Institute of Molecular and Cellular Biology SB RAS) ;
Lemskaya, Natalya A. (Institute of Molecular and Cellular Biology SB RAS) ;
Serdyukova, Natalya A. (Institute of Molecular and Cellular Biology SB RAS) ;
Modina, Svetlana A. (Institute of Molecular and Cellular Biology SB RAS) ;
Perelman, Polina L. (Institute of Molecular and Cellular Biology SB RAS) ;
Kizilova, Elena A. (Institute of Cytology and Genetics SB RAS) ;
Baiborodin, Sergei I. (Institute of Cytology and Genetics SB RAS) ;
Rubtsov, Nikolai B. (Institute of Cytology and Genetics SB RAS) ;
Machol, Gur (Baylor College of Medicine) ;
Rath, Krisha (Baylor College of Medicine) ;
Mahajan, Ragini (Rice University) ;
Kaur, Parwinder (UWA University of Western Australia) ;
Gnirke, Andreas (Broad Institute of MIT and Harvard) ;
Garcia-Treviño, Isabel (San Antonio Zoo) ;
Coke, Rob (San Antonio Zoo) ;
Flanagan, Joseph P. (Houston Zoo) ;
Pletch, Kelcie (Houston Zoo) ;
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cellular, Fisiologia I Immunologia) ;
Plotnikov, Valerii (Academy of Sciences of Sakha Republic) ;
Pavlov, Innokentiy S. (Academy of Sciences of Sakha Republic) ;
Pavlova, Naryya I. (Institute of Biological Problems of Cryolitezone SB RAS) ;
Protopopov, Albert V. (North-Eastern Federal University) ;
Di Pierro, Michele (Northeastern University) ;
Graphodatsky, Alexander S. (Institute of Molecular and Cellular Biology SB RAS) ;
Lander, Eric S. (Department of Biology. Massachusetts Institute of Technology) ;
Rowley, M. Jordan (University of Nebraska Medical Center) ;
Wolynes, Peter G. (Rice University) ;
Onuchic, José N. (Rice University) ;
Dalén, Love (Stockholm University) ;
Marti-Renom, MarcA. (Universitat Pompeu Fabra) ;
Gilbert, M.Thomas P. (University Museum NTNU) ;
Aiden, Erez L. (Broad Institute of MIT and Harvard) ;
Universitat Autònoma de Barcelona.
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Analyses of ancient DNA typically involve sequencing the surviving short oligonucleotides and aligning to genome assemblies from related, modern species. Here, we report that skin from a female woolly mammoth (†Mammuthus primigenius) that died 52,000 years ago retained its ancient genome architecture. [...]
2024 - 10.1016/j.cell.2024.06.002
Cell, Vol. 187, Issue 14 (July 2024) , p. 3541-3562.e51
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