Institut de Biotecnologia i de Biomedicina (IBB)

The Institut de Biotecnologia i de Biomedicina (IBB) was created in 1970 as a research institute of the Universitat Autònoma de Barcelona (UAB). Although the institute was originally devoted to promoting fundamental biological research, we have been focusing in the Biotechnology and Biomedicine fields for the last 20 years.

At the IBB we conduct top-level scientific research with the aim of advancing scientific findings into translational results, to revert our knowledge to society. Our researchers participate in high competitive calls, both national and internationally, aimed at funding basic and translational research.

Among the over 200 researchers currently working at the IBB, there are lecturers and professors from the UAB, ICREA and other senior researchers, postdoctoral fellows, and PhD and Master students. The IBB hosts 18 research groups organised into 3 programmes covering different areas of scientific expertise that include bioinformatics, cellular and structural biology, genomics, immunology, microbiology and proteomics.

Our multidisciplinary character, one of the most relevant characteristics of the IBB, allows for a broad approach to biological problems, both basic and applied. The IBB researchers have expertise in several topics within the biomedicine and the biotechnology field.

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2026-01-28
20:10
14 p, 3.4 MB Where do sea turtles forage in the Mediterranean sea? Filling the gaps for a regional assessment of migration routes / Vela-Garcia, Helena (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Karaman, Sezgin (Hakkari University) ; Sürücü, Bahattin (Camikebir Mahallesi) ; Turkozan, Oguz (Aydın Adnan Menderes University) ; Pascual, Marta (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Pegueroles Queralt, Maria Cinta (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Carreras, Carles (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Sea turtles are highly migratory species that can travel vast distances between their feeding and breeding sites. Considering the vulnerability and conservation concern of most sea turtle species, it is essential to establish connections between foraging and nesting areas to link threats at seas with the affected populations. [...]
2025 - 10.3389/fmars.2025.1661954
Frontiers in marine science, Vol. 12 (November 2025) , art. 1661954  
2026-01-28
18:13
18 p, 5.6 MB De novo genome assembly, inversion detection, and worldwide adaptation on the invasive species Styela plicata / Galià Camps, Carles (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Schell, Tilman (Senckenberg Forschungsinstitut und Naturmuseum) ; Pegueroles Queralt, Maria Cinta (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Baranski, Damian (Senckenberg Forschungsinstitut und Naturmuseum) ; Ben Hamadou, Alexander (Senckenberg Forschungsinstitut und Naturmuseum) ; Horaud, Mathilde (University of Norway) ; Antich, Adrià (Centre d'Estudis Avançats de Blanes) ; Turon, Xavier (Centre d'Estudis Avançats de Blanes) ; Pascual, Marta (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Greve, Carola (Senckenberg Forschungsinstitut und Naturmuseum) ; Carreras, Carles (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Biological invasions are a major threat to biodiversity. However, genomic resources of invasive species are scarce, compromising the study of their invasive success and our ability to mitigate their effects. [...]
2025 - 10.1038/s41598-025-24574-8
Scientific reports, Vol. 15 (November 2025) , art. 40328  
2026-02-02
16:44
25 p, 1.0 MB Transcriptional Responses to Alkaline pH Across Fungi : Common and Differential Features, and Biotechnological Applications / Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
The transcriptional response to alkalinization in Saccharomyces cerevisiae, Aspergillus nidulans and Candida albicans raised the interest of the scientific community many years ago for diverse reasons, and the underlying signaling pathways have been elucidated in these organisms in detail. [...]
2025 - 10.3390/ijms262311450
International journal of molecular sciences, Vol. 26, Num. 23 (December 2025) , art. 11450  
2026-01-21
13:20
30 p, 1.9 MB Surface engineering of silica nanoparticles with a gadolinium-PCTA complex for efficient T1-weighted MRI contrast agents / Mathieu, Paul (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination) ; Chalet, Marie (Centre national de la recherche scientifique (França). Laboratoire de Synthèse et Physico-Chimie de Molécules d'Inérêt Biologique) ; Clain, Marie Myriam (Centre national de la recherche scientifique (França). Laboratoire de Synthèse et Physico-Chimie de Molécules d'Inérêt Biologique) ; Teulon, Lauryanne (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination) ; Benoist, Eric (Centre national de la recherche scientifique (França). Laboratoire de Synthèse et Physico-Chimie de Molécules d'Inérêt Biologique) ; Leygue, Nadine (Centre national de la recherche scientifique (França). Laboratoire de Synthèse et Physico-Chimie de Molécules d'Inérêt Biologique) ; Picard, Claude (Centre national de la recherche scientifique (França). Laboratoire de Synthèse et Physico-Chimie de Molécules d'Inérêt Biologique) ; Boutry, Sébastien (University of Mons) ; Laurent, Sophie (University of Mons) ; Stanicki, Dimitri (University of Mons) ; Henoumont, Céline (University of Mons) ; Novio Vázquez, Fernando (Universitat Autònoma de Barcelona. Departament de Química) ; Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Montpeyó, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ciuculescu-Pradines, Diana (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination) ; Amiens, Catherine (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination)
New pyridine containing triAza; 3,6,9,15-tetraazabicyclo[9. 3. 1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid (PCTA) ligands presenting pendant carboxylic acid or alcohol functions have been synthesized and used to form diaqua Gd(iii) complexes, which have been immobilized onto dense silica nanoparticles. [...]
2020 - 10.1039/d0nj04430j
New journal of chemistry, Vol. 44, Num. 41 (October 2020) , p. 18031-18047  
2026-01-14
18:10
43 p, 1.8 MB Deciphering the Molecular Details of the Lipoxin Formation Mechanism in the 5(S),15(S)-DiHpETE Biosynthetic Pathway Catalyzed by Reticulocyte 15-Lipoxygenase-1 / Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; González Lafont, Àngels (Universitat Autònoma de Barcelona. Departament de Química) ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Chronic inflammation is now widely recognized to play important roles in many commonly occurring diseases, including COVID-19. The resolution response to this chronic inflammation is an active process governed by specialized pro-resolving mediators (SPMs) like the lipid mediators known as lipoxins. [...]
2020 - 10.1021/acs.jpcb.0c09147
Journal of physical chemistry B, Vol. 124, Num. 50 (December 2020) , p. 11406-11418  
2026-01-08
17:10
5 p, 1011.8 KB Metagenomic survey reveals Volzhskoe tick virus in Hyalomma ticks for the first time in western Europe, North-Eastern Spain / Carrera Faja, Laura (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Jasso, Mariette Viladomat (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Sarmiento, Iris (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Cabrera Gumbau, Jordi Manuel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Espunyes, Johan (Govern d'Andorra. Ministeri de Medi Ambient, Agricultura i Ramaderia) ; Martinez-Urtaza, Jaime (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Cabezón Ponsoda, Óscar (Universitat Autònoma de Barcelona. Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal)
Ticks are reservoirs and vectors of several emerging arboviruses, yet their associated virome remains poorly characterized. Using meta-transcriptomic sequencing, we surveyed Hyalomma marginatum and Rhipicephalus bursa ticks collected from areas with contrasting Crimean-Congo haemorrhagic fever virus (CCHFV) seroprevalence in wild ungulates in north-eastern Spain, a region with no reported CCHF cases in humans. [...]
2025 - 10.1016/j.onehlt.2025.101279
One Health, Vol. 21 (December 2025) , art. 101279  
2026-01-28
16:10
23 p, 928.5 KB Minimization of spectral pattern changes during HRMAS experiments at 37 degrees celsius by prior focused microwave irradiation / Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG)) ; Candiota Silveira, Ana Paula (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Arús i Caraltó, Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Dàvila Huerta, Myriam (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Object High-resolution magic angle spinning (HRMAS) magnetic resonance spectroscopy provides detailed metabolomic information from intact tissue. However, long acquisition times and high rotation speed may lead to timedependent spectral pattern changes, which may affect proper interpretation of results. [...]
2012 - 10.1007/s10334-012-0303-1
Magnetic Resonance Materials in Physics, Biology and Medicine, Vol. 25 (2012) , p. 401-410  
2026-01-14
16:10
12 p, 656.7 KB Effects of Chronic Cortisol Administration on Global Expression of GR and the Liver Transcriptome in Sparus aurata / Teles, Mariana (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Boltana, Sebastian (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Reyes Lopez, Felipe Esteban (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Santos, Monteiro Ana (University of Aveiro. Department of Biology & CESAM) ; Mackenzie, Simon (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Tort Bardolet, Lluís (Universitat Autònoma de Barcelona. Departament de Biologia Cel.lular, de Fisiologia i d'Immunologia)
The present work was designed to assess the effects of artificially increased high plasma cortisol levels induced by slow-release cortisol implants on the mRNA abundance of the glucocorticoid receptor (GR) in different organs of Sparus aurata (Gilthead sea bream), as well as to evaluate global transcriptional changes in the liver, using the Aquagenomics S. [...]
2013 - 10.1007/s10126-012-9467-y
Marine Biotechnology, Vol. 15, Num. 1 (February 2013) , p. 104-114  
2026-01-20
21:42
46 p, 2.3 MB Incremental Gaussian Discriminant Analysis based on Graybill and Deal weighted combination of estimators for brain tumour diagnosis / Tortajada, Salvador (Universitat Politècnica de València) ; Fuster-Garcia, Elies (Universitat Politècnica de València) ; Vicente, Javier (Universitat Politècnica de València) ; Wesseling, Pieter (Radboud University Nijmegen Medical Centre) ; Howe, Franklyn A. (St George's University of London) ; Julià Sapé, Ma. Margarita (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Candiota Silveira, Ana Paula (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Monleon, Daniel (Fundación Investigación Hospital Clínico Valencia) ; Moreno Torres, Angel (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Pujol Nuez, Jesús (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Griffiths, John R. (Cambridge Research Institute) ; Wright, Alan (Radboud University Nijmegen Medical Centre) ; Peet, Andrew C. (University of Birmingham) ; Martínez Bisbal, M. Carmen (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Celda Muñoz, Bernardo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Arús i Caraltó, Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Robles, Montserrat (Universitat Politècnica de València) ; García Gómez, Juan Miguel (Universitat Politècnica de València)
In the last decade, machine learning (ML) techniques have been used for developing classifiers for automatic brain tumour diagnosis. However, the development of these ML models rely on a unique training set and learning stops once this set has been processed. [...]
2011 - 10.1016/j.jbi.2011.02.009
Journal of Biomedical Informatics, Vol. 44 (2011) , p. 677-687  
2026-01-09
13:11
17 p, 455.3 KB Mass spectrometry footprinting reveals how kinetic stabilizers counteract transthyretin dynamics altered by pathogenic mutations / Garcia de Carvalho Pinheiro, Francisca (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Kant, Ravi (The George Washington University. Department of Chemistry) ; Chemuru, Saketh (The George Washington University. Department of Chemistry) ; Varejão, Nathalia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Velázquez-Campoy, Adrián (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ; Reverter Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Gross, Michael L. (The George Washington University. Department of Chemistry) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
The aggregation of transthyretin (TTR) results in life-threatening transthyretin amyloidosis. Familial forms of the disease arise from point mutations that destabilize the TTR tetramer, leading to its dissociation and/or monomer unfolding and subsequent formation of amyloid fibrils. [...]
2025 - 10.1073/pnas.2519908122
Proceedings of the National Academy of Sciences of The United States Of America, Vol. 123, Num. 1 (desembre 2025) , art. e2519908122