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16 p, 7.0 MB |
Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens
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Gómez, Andromeda-Celeste (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Lyons, Thérèse (University College Cork. School of Pharmacy) ;
Mamat, Uwe (Leibniz Lung Center. Cellular Microbiology) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bravo, Marc (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Elshafee, Osama (Leibniz Institute for Natural Product Research and Infection Biology. Department of Microbial Pathogenicity Mechanisms) ;
Brunke, Sascha (Leibniz Institute for Natural Product Research and Infection Biology. Department of Microbial Pathogenicity Mechanisms) ;
Gahan, Cormac G.M. (University College Cork. APC Microbiome Ireland) ;
O'Driscoll, Michelle (University College Cork. Analytical and Biological Chemistry Research Facility) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
O'Sullivan, Timothy P. (University College Cork. Analytical and Biological Chemistry Research Facility)
Diseases caused by biofilm-forming pathogens are becoming increasingly prevalent and represent a major threat to human health. This trend has prompted a search for novel inhibitors of microbial biofilms which could, for example, be used to potentiate existing antibiotics. [...]
2022 -  10.1016/j.ejmech.2022.114678
European Journal of Medicinal Chemistry, Vol. 242 (November 2022) , art. 114678
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2.
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2 p, 722.3 KB |
Noves molècules que inhibeixen la formació de biofilm en diversos patògens oportunistes
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Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Investigadors del grup de recerca en Patogènesi Bacteriana i Antimicrobians de l'Institut de Biotecnologia i de Biomedicina i del Departament de Genètica i de Microbiologia (IBB) i del Departament de Genètica i de Microbiologia han avaluat diversos compostos que han demostrat inhibir la formació de biofilm en patògens humans oportunistes d'importància clínica. [...]
Investigadores del grupo de investigación en Patogénesis Bacteriana y Antimicrobianos del Instituto de Biotecnología y de Biomedicina (IBB) y del Departamento de Genética y Microbiología de la UAB han evaluado varios compuestos que han demostrado inhibir la formación de biofilm en patógenos humanos oportunistas de importancia clínica. [...]
Researchers from the Bacterial Pathogenesis and Antimicrobials group of the Institut de Biotecnologia i de Biomedicina (IBB) and the Department of Genetics and Microbiology at UAB, have evaluated several compounds that have been shown to inhibit biofilm formation in important opportunistic human pathogens. [...]
2022
UAB divulga, Setembre 2022
3 documents
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15 p, 2.0 MB |
Strain-specific interspecies interactions between co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization
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Gomes Fernandes, Meissiner (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bravo, Marc (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Huedo Moreno, Pol (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Coves, Xavier (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Dual species interactions in co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization were examined. The genetic and phenotypic diversity between the isolates was high making the interactions detected strain-specific. [...]
2022 - 10.1038/s41598-022-07018-5
Scientific reports, Vol. 12 (March 2022) , art. 3374
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4.
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15 p, 1.6 MB |
Genetic Variants of the DSF Quorum Sensing System in Stenotrophomonas maltophilia Influence Virulence and Resistance Phenotypes Among Genotypically Diverse Clinical Isolates
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Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Huedo Moreno, Pol (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Martínez-Servat, Sònia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mamat, Uwe (Leibniz Lung Center) ;
Coves, Xavier (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Llanas, Ferran (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Roca, Ignasi (Institut de Salut Global de Barcelona) ;
Vila Estapé, Jordi (Institut de Salut Global de Barcelona) ;
Schaible, Ulrich E. (Leibniz Lung Center) ;
Daura i Ribera, Xavier (Institució Catalana de Recerca i Estudis Avançats) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The pathogenicity of Stenotrophomonas maltophilia is regulated in part by its quorum sensing (QS) system. The main QS signaling molecule in S. maltophilia is known as diffusible signal factor (DSF), and the rpf gene cluster is responsible for its synthesis and perception. [...]
2020 - 10.3389/fmicb.2020.01160
Frontiers in microbiology, Vol. 11 (June 2020) , art. 1160
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5.
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12 p, 2.3 MB |
The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia
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Gröschel, Matthias I. (University Medical Center Groningen. Department of Pulmonary Diseases & Tuberculosis) ;
Meehan, Conor J. (University of Bradford. School of Chemistry and Bioscience) ;
Barilar, Ivan (Research Center Borstel. Molecular and Experimental Mycobacteriology) ;
Diricks, Margo (BioMérieux) ;
Gonzaga, Aitor (Leibniz Institute DSMZ. German Collection of Microorganisms and Cell Cultures) ;
Steglich, Matthias (Leibniz Institute DSMZ. German Collection of Microorganisms and Cell Cultures) ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Scherer, Isabell-Christin (University Hospital Schleswig-Holstein. Department of Infectious Diseases and Microbiology) ;
Mamat, Uwe (Cellular Microbiology, Research Center Borstel) ;
Luz, Christian F. (University Medical Center Groningen. Department of Medical Microbiology and Infection Prevention) ;
De Bruyne, Katrien (bioMérieux, Applied Maths NV) ;
Utpatel, Christian (Research Center Borstel. Molecular and Experimental Mycobacteriology) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Kampmeier, Stefanie (University Hospital of Münster (Alemanya)) ;
Rahman, Nurdyana Abdul (Singapore General Hospital. Department of Microbiology) ;
Kresken, Michael (Rheinische Fachhochschule Köln gGmbH) ;
van der Werf, Tjip S. (University Medical Center Groningen. Department of Pulmonary Diseases & Tuberculosis) ;
Alio, Ifey (University of Hamburg. Department of Microbiology and Biotechnology) ;
Streit, Wolfgang R. (University of Hamburg. Department of Microbiology and Biotechnology) ;
Zhou, Kai (Jinan University. Second Clinical Medical College) ;
Schwartz, Thomas (Karlsruhe Institute of Technology) ;
Rossen, John W. A. (University Medical Center Groningen. Department of Medical Microbiology and Infection Prevention) ;
Farhat, Maha R. (Massachusetts General Hospital (Boston)) ;
Schaible, Ulrich E. (Leibniz Research Alliance Infections'21) ;
Nübel, Ulrich (Technical University. Braunschweig Integrated Center of Systems Biology) ;
Rupp, Jan (German Center for Infection Research) ;
Steinmann, Joerg (Paracelsus Medical Private University) ;
Niemann, Stefan (Leibniz Research Alliance Infections'21) ;
Kohl, Thomas A. (German Center for Infection Research)
Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. [...]
2020 - 10.1038/s41467-020-15123-0
Nature communications, Vol. 11 (April 2020) , art. 2044
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16 p, 3.0 MB |
The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm
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Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Díaz-Lobo, Mireia (Institut de Recerca Biomèdica) ;
Costenaro, Lionel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mayo, Adrià (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer-Navarro, Mario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vilaseca, Marta (Institut de Recerca Biomèdica) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
In Pseudomonas aeruginosa, Ttg2D is the soluble periplasmic phospholipid-binding component of an ABC transport system thought to be involved in maintaining the asymmetry of the outer membrane. Here we use the crystallographic structure of Ttg2D at 2. [...]
2021 - 10.1038/s42003-021-01968-8
Communications Biology, Vol. 4 (April 2021) , art. 448
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21 p, 4.1 MB |
Phenotypic and transcriptomic analyses of seven clinical Stenotrophomonas maltophilia isolates identify a small set of shared and commonly regulated genes involved in the biofilm lifestyle
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Alio, Ifey (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Gudzuhn, Mirja (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Pérez García, Pablo (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Danso, Dominik (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Schoelmerich, Marie Charlotte (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Mamat, Uwe (Research Center Borstel. Priority Area Infections. Molecular and Experimental Mycobacteriology (Germany)) ;
Schaible, Ulrich E. (Research Center Borstel. Priority Area Infections. Molecular and Experimental Mycobacteriology (Germany)) ;
Steinmann, Jörg (Universitätsinstitut der Paracelsus Medizinischen Privatuniversität Klinikum Nürnberg. Institut für Klinikhygiene, Medizinische Mikrobiologie und Klinische Infektiologie (Germany)) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Kohl, Thomas A. (Research Center Borstel. Molecular and Experimental Mycobacteriology (Germany)) ;
Niemann, Stefan (Research Center Borstel. Molecular and Experimental Mycobacteriology (Germany)) ;
Gröschel, Matthias I. (Harvard Medical School. Department of Biomedical Informatics (USA)) ;
Haerdter, Johanna (Universität Hamburg. Institute of Organic Chemistry (Germany)) ;
Hackl, Thomas (Universität Hamburg. Institute of Organic Chemistry (Germany)) ;
Vollstedt, Christel (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Bömeke, Mechthild (Georg-August University of Göttingen. Institute of Microbiology and Genetics. Department of Genomic and Applied Microbiology (Germany)) ;
Egelkamp, Richard (Georg-August University of Göttingen. Institute of Microbiology and Genetics. Department of Genomic and Applied Microbiology (Germany)) ;
Daniel, Rolf (Georg-August University of Göttingen. Institute of Microbiology and Genetics. Department of Genomic and Applied Microbiology (Germany)) ;
Poehlein, Anja (Georg-August University of Göttingen. Institute of Microbiology and Genetics. Department of Genomic and Applied Microbiology (Germany)) ;
Streit, Wolfgang R. (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Stenotrophomonas maltophilia is one of the most frequently isolated multidrug-resistant nosocomial opportunistic pathogens. It contributes to disease progression in cystic fibrosis (CF) patients and is frequently isolated from wounds, infected tissues, and catheter surfaces. [...]
2020 - 10.1128/AEM.02038-20
Applied and Environmental Microbiology, Vol. 86, Issue 24 (December 2020) , art. e02038
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15 p, 1.4 MB |
E-cigarettes : effects in phagocytosis and cytokines response against Mycobacterium tuberculosis
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Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Rodríguez Fernández, Pablo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villar Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Cigarette smoking and tuberculosis are a significant cause of death worldwide. Several epidemiological studies have demonstrated cigarette smoking is a risk factor for tuberculosis. Electronic cigarettes have recently appeared as a healthier alternative to conventional smoking, although their impact in tuberculosis is not well understood. [...]
2020 - 10.1371/journal.pone.0228919
PloS one, Vol. 15 issue 2 (2020) , p. e0228919
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10 p, 1.4 MB |
Heterogeneous colistin-resistance phenotypes coexisting in stenotrophomonas maltophiliaisolates influence colistin susceptibility testing
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Martínez-Servat, Sònia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Huedo Moreno, Pol (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Marquez, Roser (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Molina, Gara (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The polymyxin antibiotic colistin shows in vitro activity against Stenotrophomonas maltophilia. However, an increased incidence of colistin-resistant isolates has been recently observed. In addition, in vitro evaluation of colistin susceptibility for this organism has been problematic. [...]
2018 - 10.3389/fmicb.2018.02871
Frontiers in microbiology, Vol. 9 (Nov. 2018) , art. 2871
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2 p, 447.8 KB |
Confondre per vèncer : interferir en la comunicació bacteriana com estratègia per a combatre els patògens resistents a antibiòtics
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Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Investigadors del grup de recerca en Patogènesi Bacteriana i Antimicrobians de l'Institut de Biotecnologia i de Biomedicina i del Departament de Genètica i de Microbiologia de la UAB, en col·laboració amb el grup de Química Farmacèutica de la University College Cork (Irlanda), han dissenyat i avaluat noves molècules capaces d'interferir amb la comunicació bacteriana alterant-ne la formació de biofilm i potenciant l'activitat de la colistina, un dels antibiòtics d'últim recurs.
Investigadores del grupo de investigación en Patogénesis Bacteriana y Antimicrobianos del Instituto de Biotecnología y de Biomedicina y del Departamento de Genética y Microbiología de la UAB, en colaboración con el grupo de Química Farmacéutica de la University College Cork (Irlanda), han diseñado y evaluado nuevas moléculas capaces de interferir con la comunicación bacteriana alterando la formación de biofilm y potenciando la actividad de la colistina, uno de los antibióticos de último recurso.
Researchers from the Bacterial Pathogenesis and Antimicrobials group of the Institut de Biotecnologia i de Biomedicina (IBB) and the Department of Genetics and Microbiology at UAB, in collaboration with the Pharmaceutical Chemistry group of the University College Cork (Ireland), have designed and evaluated new molecules capable of interfering with bacterial communication by altering biofilm formation and enhancing the activity of colistin, one of the last resort antibiotics.
2019
UAB divulga, Octubre 2019, p. 1-2
3 documents
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