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1.
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12 p, 2.3 MB |
The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia
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Gröschel, Matthias I. (University Medical Center Groningen. Department of Pulmonary Diseases & Tuberculosis) ;
Meehan, Conor J. (University of Bradford. School of Chemistry and Bioscience) ;
Barilar, Ivan (Research Center Borstel. Molecular and Experimental Mycobacteriology) ;
Diricks, Margo (BioMérieux) ;
Gonzaga, Aitor (Leibniz Institute DSMZ. German Collection of Microorganisms and Cell Cultures) ;
Steglich, Matthias (Leibniz Institute DSMZ. German Collection of Microorganisms and Cell Cultures) ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Scherer, Isabell-Christin (University Hospital Schleswig-Holstein. Department of Infectious Diseases and Microbiology) ;
Mamat, Uwe (Cellular Microbiology, Research Center Borstel) ;
Luz, Christian F. (University Medical Center Groningen. Department of Medical Microbiology and Infection Prevention) ;
De Bruyne, Katrien (bioMérieux, Applied Maths NV) ;
Utpatel, Christian (Research Center Borstel. Molecular and Experimental Mycobacteriology) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Kampmeier, Stefanie (University Hospital of Münster (Alemanya)) ;
Rahman, Nurdyana Abdul (Singapore General Hospital. Department of Microbiology) ;
Kresken, Michael (Rheinische Fachhochschule Köln gGmbH) ;
van der Werf, Tjip S. (University Medical Center Groningen. Department of Pulmonary Diseases & Tuberculosis) ;
Alio, Ifey (University of Hamburg. Department of Microbiology and Biotechnology) ;
Streit, Wolfgang R. (University of Hamburg. Department of Microbiology and Biotechnology) ;
Zhou, Kai (Jinan University. Second Clinical Medical College) ;
Schwartz, Thomas (Karlsruhe Institute of Technology) ;
Rossen, John W. A. (University Medical Center Groningen. Department of Medical Microbiology and Infection Prevention) ;
Farhat, Maha R. (Massachusetts General Hospital) ;
Schaible, Ulrich E. (Leibniz Research Alliance Infections'21) ;
Nübel, Ulrich (Technical University. Braunschweig Integrated Center of Systems Biology) ;
Rupp, Jan (German Center for Infection Research) ;
Steinmann, Joerg (Paracelsus Medical Private University) ;
Niemann, Stefan (Leibniz Research Alliance Infections'21) ;
Kohl, Thomas A. (German Center for Infection Research)
Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. [...]
2020 -  10.1038/s41467-020-15123-0
Nature communications, Vol. 11 (April 2020) , art. 2044
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2.
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16 p, 3.0 MB |
The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm
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Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Díaz-Lobo, Mireia (Institut de Recerca Biomèdica) ;
Costenaro, Lionel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mayo, Adrià (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer-Navarro, Mario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vilaseca, Marta (Institut de Recerca Biomèdica) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
In Pseudomonas aeruginosa, Ttg2D is the soluble periplasmic phospholipid-binding component of an ABC transport system thought to be involved in maintaining the asymmetry of the outer membrane. Here we use the crystallographic structure of Ttg2D at 2. [...]
2021 - 10.1038/s42003-021-01968-8
Communications Biology, Vol. 4 (April 2021) , art. 448
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3.
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21 p, 4.1 MB |
Phenotypic and transcriptomic analyses of seven clinical Stenotrophomonas maltophilia isolates identify a small set of shared and commonly regulated genes involved in the biofilm lifestyle
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Alio, Ifey (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Gudzuhn, Mirja (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Pérez García, Pablo (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Danso, Dominik (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Schoelmerich, Marie Charlotte (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Mamat, Uwe (Research Center Borstel. Priority Area Infections. Molecular and Experimental Mycobacteriology (Germany)) ;
Schaible, Ulrich E. (Research Center Borstel. Priority Area Infections. Molecular and Experimental Mycobacteriology (Germany)) ;
Steinmann, Jörg (Universitätsinstitut der Paracelsus Medizinischen Privatuniversität Klinikum Nürnberg. Institut für Klinikhygiene, Medizinische Mikrobiologie und Klinische Infektiologie (Germany)) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Kohl, Thomas A. (Research Center Borstel. Molecular and Experimental Mycobacteriology (Germany)) ;
Niemann, Stefan (Research Center Borstel. Molecular and Experimental Mycobacteriology (Germany)) ;
Gröschel, Matthias I. (Harvard Medical School. Department of Biomedical Informatics (USA)) ;
Haerdter, Johanna (Universität Hamburg. Institute of Organic Chemistry (Germany)) ;
Hackl, Thomas (Universität Hamburg. Institute of Organic Chemistry (Germany)) ;
Vollstedt, Christel (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Bömeke, Mechthild (Georg-August University of Göttingen. Institute of Microbiology and Genetics. Department of Genomic and Applied Microbiology (Germany)) ;
Egelkamp, Richard (Georg-August University of Göttingen. Institute of Microbiology and Genetics. Department of Genomic and Applied Microbiology (Germany)) ;
Daniel, Rolf (Georg-August University of Göttingen. Institute of Microbiology and Genetics. Department of Genomic and Applied Microbiology (Germany)) ;
Poehlein, Anja (Georg-August University of Göttingen. Institute of Microbiology and Genetics. Department of Genomic and Applied Microbiology (Germany)) ;
Streit, Wolfgang R. (Universität Hamburg. Department of Microbiology and Biotechnology (Germany)) ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Stenotrophomonas maltophilia is one of the most frequently isolated multidrug-resistant nosocomial opportunistic pathogens. It contributes to disease progression in cystic fibrosis (CF) patients and is frequently isolated from wounds, infected tissues, and catheter surfaces. [...]
2020 - 10.1128/AEM.02038-20
Applied and Environmental Microbiology, Vol. 86, Issue 24 (December 2020) , art. e02038
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4.
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15 p, 1.4 MB |
E-cigarettes : effects in phagocytosis and cytokines response against Mycobacterium tuberculosis
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Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Rodríguez Fernández, Pablo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villar Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Cigarette smoking and tuberculosis are a significant cause of death worldwide. Several epidemiological studies have demonstrated cigarette smoking is a risk factor for tuberculosis. Electronic cigarettes have recently appeared as a healthier alternative to conventional smoking, although their impact in tuberculosis is not well understood. [...]
2020 - 10.1371/journal.pone.0228919
PloS one, Vol. 15 issue 2 (2020) , p. e0228919
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5.
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10 p, 1.4 MB |
Heterogeneous colistin-resistance phenotypes coexisting in stenotrophomonas maltophiliaisolates influence colistin susceptibility testing
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Martínez-Servat, Sònia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Huedo Moreno, Pol (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Marquez, Roser (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Molina, Gara (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The polymyxin antibiotic colistin shows in vitro activity against Stenotrophomonas maltophilia. However, an increased incidence of colistin-resistant isolates has been recently observed. In addition, in vitro evaluation of colistin susceptibility for this organism has been problematic. [...]
2018 - 10.3389/fmicb.2018.02871
Frontiers in microbiology, Vol. 9 (Nov. 2018) , art. 2871
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2 p, 447.8 KB |
Confondre per vèncer : interferir en la comunicació bacteriana com estratègia per a combatre els patògens resistents a antibiòtics
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Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Investigadors del grup de recerca en Patogènesi Bacteriana i Antimicrobians de l'Institut de Biotecnologia i de Biomedicina i del Departament de Genètica i de Microbiologia de la UAB, en col·laboració amb el grup de Química Farmacèutica de la University College Cork (Irlanda), han dissenyat i avaluat noves molècules capaces d'interferir amb la comunicació bacteriana alterant-ne la formació de biofilm i potenciant l'activitat de la colistina, un dels antibiòtics d'últim recurs.
Investigadores del grupo de investigación en Patogénesis Bacteriana y Antimicrobianos del Instituto de Biotecnología y de Biomedicina y del Departamento de Genética y Microbiología de la UAB, en colaboración con el grupo de Química Farmacéutica de la University College Cork (Irlanda), han diseñado y evaluado nuevas moléculas capaces de interferir con la comunicación bacteriana alterando la formación de biofilm y potenciando la actividad de la colistina, uno de los antibióticos de último recurso.
Researchers from the Bacterial Pathogenesis and Antimicrobials group of the Institut de Biotecnologia i de Biomedicina (IBB) and the Department of Genetics and Microbiology at UAB, in collaboration with the Pharmaceutical Chemistry group of the University College Cork (Ireland), have designed and evaluated new molecules capable of interfering with bacterial communication by altering biofilm formation and enhancing the activity of colistin, one of the last resort antibiotics.
2019
UAB divulga, Octubre 2019, p. 1-2
3 documents
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7.
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8 p, 3.3 MB |
Utilitat de la determinació del DNA del virus de l'hepatitis B en serum per hibridació molecular
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Costa, J. (Joan) (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Barbé García, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
García-Bernabé, V. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Sánchez Tapias, J. M. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Rodés, Joan (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Mediante una técnica de hibridación molecular, utilizando como sonda DNA-VHB purificado de un plasmido recombinante, se ha examinado la presencia de DNA-VHB en el suero de 82 portadores crónicos de HBsAg(RIA) sin evidenciashade infección Delta y en 80 sujetos HBsAg negativos (40 donantes de Sangre y 40 con hepatitis crónica o cirrosis no alcohólica). [...]
1990
Treballs de la Societat Catalana de Biologia, Vol. 41 (1990) , p. 71-78
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9.
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33 p, 4.2 MB |
Nanostructured recombinant cytokines : A highly stable alternative to short-lived prophylactics
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Torrealba, Debora (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Parra, David (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Seras-Franzoso, Joaquin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vallejos Vidal, Eva Carolina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Garcia-Fruitos, Elena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Roher Armentia, Nerea (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Cytokines have been widely used as adjuvants and therapeutic agents in treatments of human diseases. Despite their recognized potential as drugs, the medical use of cytokines has considerable drawbacks, mainly related to their low stability and short half-life. [...]
2016 - 10.1016/j.biomaterials.2016.08.043
Biomaterials, Vol. 107 (Novembre 2016) , p. 102-114
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10.
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7 p, 544.8 KB |
Triclosan-induced genes Rv1686c-Rv1687c and Rv3161c are not involved in triclosan resistance in Mycobacterium tuberculosis
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Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Andreu Martín, Núria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer-Navarro, Mario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
A key issue towards developing new chemotherapeutic approaches to fight Mycobacterium tuberculosis is to understand the mechanisms underlying drug resistance. Previous studies have shown that genes Rv1686c-Rv1687c and Rv3161c, predicted to encode an ATP-binding cassette transporter and a dioxygenase respectively, are induced in the presence of triclosan and other antimicrobial compounds. [...]
2016 - 10.1038/srep26221
Scientific reports (Nature Publishing Group), Vol 6 (May 2016) , p. 26221
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