Institut de Biotecnologia i de Biomedicina (IBB)

L’ Institut de Biotecnologia i de Biomedicina (IBB) va ser creat el 1970 com a institut de recerca de la Universitat Autònoma de Barcelona (UAB). Tot i que l’institut es va dedicar originalment a promoure la investigació biològica fonamental, ens hem centrat en els camps de Biotecnologia i Biomedicina durant els darrers vint anys.

A l'IBB portem a terme investigacions científiques capdavanteres amb l'objectiu d'avançar en el coneixement i poder traduir les troballes científiques en eines tangibles, per revertir el nostre coneixement a la societat. Els nostres investigadors participen en convocatòries altament competitives, tant nacionals com internacionals, destinades a finançar investigacions bàsiques i translacionals.

Entre els més de 200 investigadors que actualment treballen a l’IBB, hi ha professors de la UAB, ICREA i altres investigadors sèniors, becaris postdoctorals i estudiants de doctorat o de màster. L’IBB acull 18 grups de recerca organitzats en 3 programes que abasten diferents àrees d’expertesa científica que inclouen bioinformàtica, biologia cel·lular i estructural, genòmica, immunologia, microbiologia i proteòmica.

El nostre caràcter multidisciplinari, una de les característiques més rellevants de l’IBB, permet un enfocament ampli dels problemes biològics, tant bàsics com aplicats. Els investigadors de l'IBB tenen experiència en diversos temes dins de la biomedicina i en el camp de la biotecnologia.

Estadístiques d'ús Els més consultats
Darreres entrades:
2020-06-22
12:28
112 p, 6.6 MB Annual report / Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Informe annual de l'Institut de Biotecnologia i Biomedicina "Vicent Villar Palasí".
Bellaterra Institut de Biotecnologia i Biomedicina 2013-
7 documents
2020-06-22
11:26
41 p, 2.4 MB Autophagy modulators : mechanistic aspects and drug delivery systems / Tavakol, Shima (Iran University of Medical Sciences. Cellular and Molecular Research Center) ; Ashrafizadeh, Milad (University of Tabriz. Department of basic science) ; Deng, Shuo (National University of Singapore. Department of Physiology) ; Azarian, Maryam (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Abdoli, Asghar (Pasteur Institute of Iran. Department of Hepatitis and AIDS) ; Motavaf, Mahsa (Tarbiat Modares University. Department of Molecular Genetics) ; Poormoghadam, Delaram (Islamic Azad University. Department of Medical Nanotechnology) ; Khanbabaei, Hashem (Ahvaz Jundishapur University of Medical Sciences. Medical Physics Departmen) ; Ghasemipour Afshar, Elham (Kerman University of Medical Sciences. Neuroscience Research Center) ; Mandegary, Ali (Kerman University of Medical Sciences. Neuroscience Research Center) ; Pardakhty, Abbas (Kerman University of Medical Sciences. Neuroscience Research Center) ; Yap, Celestial T. (National University of Singapore. Department of Physiology) ; Mohammadinejad, Reza (Kerman University of Medical Sciences. Pharmaceutics Research Center) ; Prem Kumar, Alan (Cancer Science Institute of Singapore) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate causes of diseases and to understand whether autophagy plays a cytoprotective or cytotoxic/cytostatic role in the progression and prevention of disease. [...]
2019 - 10.3390/biom9100530
Biomolecules, Vol. 9, issue 10 (Sep. 2019) , art. 530  
2020-06-22
11:26
18 p, 3.6 MB hnRNPDL phase separation is regulated by alternative splicing and disease-causing mutations accelerate its aggregation / Batlle Carreras, Cristina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Yang, Peiguo (St. Jude Children's Research Hospital. Department of Cell and Molecular Biology) ; Coughlin, Maura (St. Jude Children's Research Hospital. Department of Cell and Molecular Biology) ; Messing, James (Howard Hughes Medical Institute) ; Pesarrodona Roches, Mireia (Institut de Recerca Biomèdica) ; Szulc, Elzbieta (Institut de Recerca Biomèdica) ; Salvatella, Xavier (Institut de Recerca Biomèdica) ; Kim, Hong Joo (St. Jude Children's Research Hospital. Department of Cell and Molecular Biology) ; Taylor, J. Paul (Howard Hughes Medical Institute) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Prion-like proteins form multivalent assemblies and phase separate into membraneless organelles. Heterogeneous ribonucleoprotein D-like (hnRNPDL) is a RNA-processing prion-like protein with three alternative splicing (AS) isoforms, which lack none, one, or both of its two disordered domains. [...]
2020 - 10.1016/j.celrep.2019.12.080
Cell Reports, Vol. 30, issue 4 (Jan. 2020) , p. 1117-1128  
2020-06-22
11:26
14 p, 3.3 MB Interaction of camel Lactoferrin derived peptides with DNA : a molecular dynamics study / Pirkhezranian, Zana (Ferdowsi University of Mashhad. Department of Animal Science) ; Tahmoorespur, Mojtaba. (Ferdowsi University of Mashhad. Department of Animal Science) ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Monhemi, Hassan (University of Neyshabur. Department of Chemistry) ; Sekhavati, Mohammad Hadi (Ferdowsi University of Mashhad. Department of Animal Science)
Background: lactoferrampin (LFampin), Lactoferricin (LFcin), and LFchimera are three well-known antimicrobial peptides derived from Lactoferrin and proposed as alternatives for antibiotics. Although the intracellular activity of these peptides has been previously demonstrated, their mode of action is not yet fully understood. [...]
2020 - 10.1186/s12864-020-6458-7
BMC Genomics, Vol. 21 (2020) , art. 60  
2020-06-22
11:26
16 p, 21.0 MB Transcriptional response to metal starvation in the emerging pathogen Mycoplasma genitalium is mediated by Fur-dependent and -independent regulatory pathways / Martínez Torró, Carlos (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Torres Puig, Sergi (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Monge, Marta (Vall d'Hebron. Institut d'Oncologia) ; Sánchez Alba, Lucía (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; González Martín, Miguel (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marcos Silva, Marina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Perálvarez Marín, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Canals, Francesc (Vall d'Hebron. Institut d'Oncologia) ; Querol Murillo, Enrique (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Quijada Pich, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Transition metals participate in numerous enzymatic reactions and they are essential for survival in all living organisms. For this reason, bacterial pathogens have evolved dedicated machineries to effectively compete with their hosts and scavenge metals at the site of infection. [...]
2020 - 10.1080/22221751.2019.1700762
Emerging Microbes and Infections, Vol. 9, issue 1 (Jan. 2020) , p. 5-19  
2020-06-22
11:19
Editorial : protein solubility and aggregation in bacteria / Ventura, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
The Editorial on the research topic protein solubility and aggregation in bacteria.
2016 - 10.3389/fmicb.2016.01178
Frontiers in Microbiology, Vol. 7 (July 2016) , art. 1178  
2020-06-22
11:19
4 p, 2.2 MB The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles / Sánchez García, Laura (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Serna Romero, Naroa (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Mattanovich, M. (University of Natural Resources and Life Sciences. Department of Biotechnology) ; Cazzanelli, P. (University of Natural Resources and Life Sciences. Department of Biotechnology) ; Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ; Conchillo-Solé, Óscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cortés, Fran (Universitat Autònoma de Barcelona. Servei de Cultius Cellulars, Produccio´ d’Anticossos i Citometria) ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Unzueta, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ; Mangues, Ramon (Institut d'Investigació Biomèdica Sant Pau) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Vázquez Gómez, Esther (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. [...]
2017 - 10.1039/c6cc09900a
Chemical Communications, Vol. 53, issue 33 (April 2017) , p. 4565-4568  
2020-06-22
11:19
Heterogeneous colistin-resistance phenotypes coexisting in stenotrophomonas maltophiliaisolates influence colistin susceptibility testing / Martínez-Servat, Sònia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Yero Corona, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Huedo Moreno, Pol (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marquez, Roser (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Molina, Gara (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The polymyxin antibiotic colistin shows in vitro activity against Stenotrophomonas maltophilia. However, an increased incidence of colistin-resistant isolates has been recently observed. In addition, in vitro evaluation of colistin susceptibility for this organism has been problematic. [...]
2018 - 10.3389/fmicb.2018.02871
Frontiers in Microbiology, Vol. 9 (Nov. 2018) , art. 2871  
2020-06-22
11:19
13 p, 8.3 MB Understanding the molecular mechanism of the Ala-versus-Gly concept controlling the pProduct specificity in reactions catalyzed by lipoxygenases : a combined molecular dynamics and QM/MM study of coral 8R-lipoxygenase / Saura Martínez, Patricia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Suardíaz, Reynier (King's College London. Department of Chemistry) ; Masgrau, Laura (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; González Lafont, Àngels (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Rosta, Edina (King's College London. Department of Chemistry) ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Departament de Química)
Lipoxygenases (LOXs) are a family of enzymes that catalyze the highly specific hydroperoxidation of polyunsaturated fatty acids, such as arachidonic acid. Different stereo- or/and regioisomer hydroperoxidation products lead later to different metabolites that exert opposite physiological effects in the animal body and play a central role in inflammatory processes. [...]
2017 - 10.1021/acscatal.7b00842
ACS Catalysis, Vol. 7, issue 7 (July 2017) , p. 4854-4866  
2020-06-22
11:19
Discovering putative prion-like proteins in Plasmodium falciparum : a computational and experimental analysis / Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Sanchez de Groot, Natalia (Centre de Regulació Genòmica) ; Iglesias, Valentin (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sant'Anna, Ricardo (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Biosca, Arnau (Institut de Bioenginyeria de Catalunya) ; Fernàndez Busquets, Xavier (Institut de Bioenginyeria de Catalunya) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Prions are a singular subset of proteins able to switch between a soluble conformation and a self-perpetuating amyloid state. Traditionally associated with neurodegenerative diseases, increasing evidence indicates that organisms exploit prion-like mechanisms for beneficial purposes. [...]
2018 - 10.3389/fmicb.2018.01737
Frontiers in Microbiology, Vol. 9 (Aug. 2018) , art. 1737