Characteristics and Outcomes in Patients with Ventilator-Associated Pneumonia Who Do or Do Not Develop Acute Respiratory Distress Syndrome. An Observational Study
Barbeta, Enric (Hospital del Sagrat Cor (Catalunya))
Ceccato, Adrian (Hospital del Sagrat Cor (Catalunya))
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Ferrer, Miquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Fernández-Barat, Laia (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
López, Rubén (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Bueno, Leticia (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Motos, Anna (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Li Bassi, Gianluigi (The Prince Charles Hospital)
Mellado, Ricard (Hospital Clínic i Provincial de Barcelona)
Ferrando, Carlos (Hospital Clínic i Provincial de Barcelona)
Palomeque, Andrea Catalina (Hospital Clínic i Provincial de Barcelona)
Panigada, Mauro (Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico)
Gabarrús, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
de Mendoza, Diego (Hospital del Sagrat Cor (Catalunya))
Torres, Antoni (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	Ventilator-associated pneumonia (VAP) is a well-known complication of patients on invasive mechanical ventilation. The main cause of acute respiratory distress syndrome (ARDS) is pneumonia. ARDS can occur in patients with community-acquired or nosocomial pneumonia. Data regarding ARDS incidence, related pathogens, and specific outcomes in patients with VAP is limited. This is a cohort study in which patients with VAP were evaluated in an 800-bed tertiary teaching hospital between 2004 and 2016. Clinical outcomes, microbiological and epidemiological data were assessed among those who developed ARDS and those who did not. Forty-one (13. 6%) out of 301 VAP patients developed ARDS. Patients who developed ARDS were younger and presented with higher prevalence of chronic liver disease. Pseudomonas aeruginosa was the most frequently isolated pathogen, but without any difference between groups. Appropriate empirical antibiotic treatment was prescribed to ARDS patients as frequently as to those without ARDS. Ninety-day mortality did not significantly vary among patients with or without ARDS. Additionally, patients with ARDS did not have significantly higher intensive care unit (ICU) and 28-day mortality, ICU, and hospital length of stay, ventilation-free days, and duration of mechanical ventilation. In summary, ARDS deriving from VAP occurs in 13. 6% of patients. Although significant differences in clinical outcomes were not observed between both groups, further studies with a higher number of patients are needed due to the possibility of the study being underpowered.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Ventilator-associated pneumonia ; Acute respiratory distress syndrome ; Epidemiology
Publicat a:	Journal of clinical medicine, Vol. 9 (october 2020) , ISSN 2077-0383

DOI: 10.3390/jcm9113508
PMID: 33138310

11 p, 634.7 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d’Investigació i Innovació Parc Taulí (I3PT)
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