A Biomarker to differentiate between primary and cocaine-induced major depression in cocaine use disorder : the role of platelet IRAS/Nischarin (I-Imidazoline receptor)
Keller, Benjamin (Universitat de les Illes Balears)
Mestre-Pinto, Joan-Ignasi (Institut Hospital del Mar d'Investigacions Mèdiques)
Álvaro-Bartolomé, María (Universitat de les Illes Balears)
Martinez-Sanvisens, Diana (Institut Hospital del Mar d'Investigacions Mèdiques)
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
García-Fuster, M. Julia (Universitat de les Illes Balears)
García-Sevilla, Jesús A. (Universitat de les Illes Balears)
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Data: |
2017 |
Resum: |
The association of cocaine use disorder (CUD) and comorbid major depressive disorder (MDD; CUD/MDD) is characterized by high prevalence and poor treatment outcomes. CUD/MDD may be primary (primary MDD) or cocaine-induced (CUD-induced MDD). Specific biomarkers are needed to improve diagnoses and therapeutic approaches in this dual pathology. Platelet biomarkers [5-HT receptor and imidazoline receptor antisera selected (IRAS)/nischarin] were assessed by Western blot in subjects with CUD and primary MDD (n = 16) or CUD-induced MDD (n = 9; antidepressant free, AD−; antidepressant treated, AD+) and controls (n = 10) at basal level and/or after acute tryptophan depletion (ATD). Basal platelet 5-HT receptor (monomer) was reduced in comorbid CUD/MDD subjects (all patients: 43%) compared to healthy controls, and this down-regulation was independent of AD medication (decreases in AD−: 47%, and in AD+: 40%). No basal differences were found for IRAS/nischarin contents in AD+ and AD− comorbid CUD/MDD subjects. The comparison of IRAS/nischarin in the different subject groups during/after ATD showed opposite modulations (i. e. , increases and decreases) in response to low plasma tryptophan levels with significant differences discriminating between the subgroups of CUD with primary MDD and CUD-induced MDD. These specific alterations suggested that platelet IRAS/nischarin might be useful as a biomarker to discriminate between primary and CUD-induced MDD in this dual pathology. |
Drets: |
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Llengua: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Matèria: |
Platelet biomarker ;
IRAS/nischarin ;
Cocaine use disorder ;
Major depressive disorder ;
Cocaine-induced depression ;
Acute tryptophan depletion ;
Antidepressant drugs |
Publicat a: |
Frontiers in psychiatry, Vol. 8 (december 2017) , art. 258, ISSN 1664-0640 |
DOI: 10.3389/fpsyt.2017.00258
PMID: 29326609
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Registre creat el 2022-02-07, darrera modificació el 2023-08-25