Mobile therapeutic attention for treatment-resistant schizophrenia (m-RESIST) : a prospective multicentre feasibility study protocol in patients and their caregivers
Alonso-Solís, Anna (Institut d'Investigació Biomèdica Sant Pau)
Rubinstein, Katya (Sheba Medical Center, Tel-Aviv University)
Corripio, Iluminada (Institut d'Investigació Biomèdica Sant Pau)
Jaaskelainen, Erika (Oulu University Hospital (Finlàndia))
Seppälä, Annika (Oulu University Hospital (Finlàndia))
Vella, Vincenzo Alberto (Agència de Qualitat i Avaluació Sanitàries de Catalunya)
Caro-Mendivelso, Johanna (Agència de Qualitat i Avaluació Sanitàries de Catalunya)
Caspi, Asaf (Sheba Medical Center, Tel-Aviv University)
Isohanni, Matti (Oulu University Hospital (Finlàndia))
Unoka, Zsolt (Semmelweis University)
Van der Graff, Shenja (Vrije Universiteit Brussel)
Farkas, Kinga (Semmelweis University)
Huerta-Ramos, Elena (Parc Sanitari Sant Joan de Deu (PSSJD))
Marcó-García, Silvia (Parc Sanitari Sant Joan de Deu (PSSJD))
Stevens, Matthias (Imec vzw)
Coenen, Tanguy (Imec vzw)
Hospedales, Margarita (Generalitat de Catalunya)
Berdun, Jesus (Generalitat de Catalunya)
Grasa, Eva (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2018
Abstract:	Treatment-resistant schizophrenia (TRS) is a severe form of schizophrenia. In the European Union, approximately 40% of people with schizophrenia have TRS. Factors such as the persistence of positive symptoms or higher risk of comorbidities leave clinicians with a complex scenario when treating these patients. Intervention strategies based on mHealth have demonstrated their ability to support and promote self-management-based strategies. Mobile therapeutic attention for treatment-resistant schizophrenia (m-RESIST), an innovative mHealth solution based on novel technology and offering high modular and flexible functioning, has been developed specifically for patients with TRS and their caregivers. As intervention in TRS is a challenge, it is necessary to perform a feasibility study before the cost-effectiveness testing stage. This manuscript describes the protocol for a prospective multicentre feasibility study in 45 patients with TRS and their caregivers who will be attended in the public health system of three localities: Hospital Santa Creu Sant Pau (Spain), Semmelweis University (Hungary) and Gertner Institute & Sheba Medical Center (Israel). The primary aim is to investigate the feasibility and acceptability of the m-RESIST solution, configured by three mHealth tools: an app, wearable and a web-based platform. The solution collects data about acceptability, usability and satisfaction, together with preliminary data on perceived quality of life, symptoms and economic variables. The secondary aim is to collect preliminary data on perceived quality of life, symptoms and economic variables. This study protocol, funded by the Horizon 2020 Programme of the European Union, has the approval of the ethics committees of the participating institutions. Participants will be fully informed of the purpose and procedures of the study, and signed inform consents will be obtained. The results will be published in peer-reviewed journals and presented in scientific conferences to ensure widespread dissemination. ; Pre-results.
Grants:	European Commission 643552
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Treatment-resistant schizophrenia ; Mhealth ; Psychosis ; Mobile device based intervention ; Feasibility
Published in:	BMJ open, Vol. 8 (july 2018) , ISSN 2044-6055

DOI: 10.1136/bmjopen-2017-021346
PMID: 30012788

11 p, 493.9 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles