2026-03-16
10:13 |
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14 p, 7.9 MB |
Conjugation strategy shapes antitumor efficacy and enables dose-sparing in non-antibody protein nanoconjugates
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Rueda, Ariana (Institut de Recerca Sant Pau) ;
Garcia León, Annabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Arena, Lourdes Ailen (Institut de Recerca Sant Pau) ;
Mendoza, Julian Ignacio (Institut de Recerca Sant Pau) ;
Aviñó, Ana (Institut de Química Avançada de Catalunya) ;
Fabrega, Carme (Institut de Química Avançada de Catalunya) ;
Eritja, Ramon (Institut de Química Avançada de Catalunya) ;
Paez, David (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Alba Castellón, Lorena (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mangues, Ramon 1957- (Institut de Recerca Sant Pau) ;
Casanova Rigat, Isolda (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Unzueta Elorza, Ugutz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Precision targeting is a hot topic in cancer nanomedicine, as conventional chemotherapies cause systemic toxicities, creating an urgent need for more selective treatments. Although antibody-drug conjugates (ADCs) are the current gold standard in targeted therapy, their clinical performance remains limited. [...]
2026 -  10.1016/j.mtbio.2025.102698
Materials Today Bio, Vol. 36 (February 2026) , art. 102698
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2026-03-16
17:14 |
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4 p, 757.8 KB |
The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) : Ten Years of Progress in Understanding Alzheimer's in Down Syndrome
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Videla Toro, Laura (Institut de Recerca Sant Pau) ;
Benejam, Bessy (Fundació Catalana Síndrome de Down) ;
Barroeta, Isabel (Institut de Recerca Sant Pau) ;
Fernandez, Susana (Fundació Catalana Síndrome de Down) ;
Arranz Martínez, Javier (Institut de Recerca Sant Pau) ;
Rodríguez-Baz, Íñigo (Institut de Recerca Sant Pau) ;
Arriola Infante, José Enrique (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Maure Blesa, Lucia (Institut de Recerca Sant Pau) ;
Hoyo Soriano, Laura del (Institut de Recerca Sant Pau) ;
Vaqué-Alcázar, Lídia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Aranha, Mateus (Institut de Recerca Sant Pau) ;
Morcillo-Nieto, Alejandra O. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Zsadanyi, Sara E. (Institut de Recerca Sant Pau) ;
Camacho, Valle (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Giménez, Sandra (Institut de Recerca Sant Pau) ;
Belbin, Olivia (Institut de Recerca Sant Pau) ;
Alcolea, Daniel (Institut de Recerca Sant Pau) ;
Bejanin, Alexandre (Institut de Recerca Sant Pau) ;
Videla, Sebastián (Institut d'Investigació Biomèdica de Bellvitge) ;
Blesa, Rafael (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Lleó, Alberto (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Carmona Iragui, Maria (Institut de Recerca Sant Pau) ;
Fortea, Juan (Institut de Recerca Sant Pau)
Down syndrome (DS) is a form of genetically determined Alzheimer's disease (AD). Understanding the natural history and biomarker specificities in this population can offer insights into AD pathogenesis and potential treatment targets. [...]
2026 - 10.1002/alz70856_106426
Alzheimer's & dementia, Vol. 21, Num. Suppl 2 (January 2026) , art. e106426
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2026-03-13
12:12 |
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2026-03-12
14:12 |
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19 p, 245.0 KB |
Revascularization and outcomes in ischaemic left ventricular dysfunction after heart failure admission : The RevascHeart study
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Moliner-Abós, Carles (Universitat Autònoma de Barcelona) ;
Calvo-Barceló, Maria (Hospital Universitari Vall d'Hebron) ;
Solé-Gonzalez, Eduard (Hospital Clínic i Provincial de Barcelona) ;
Borrellas Martín, Andrea (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fluvià Brugués, Paula (Hospital Universitari de Girona Doctor Josep Trueta) ;
Sánchez-Vega, Jesús (Hospital Universitari de Bellvitge) ;
Taurón Ferrer, Manel (Institut de Recerca Sant Pau) ;
Tobías-Castillo, Pablo E. (Hospital Universitari Vall d'Hebron) ;
de la Fuente Mancera, Juan Carlos (Hospital Clínic i Provincial de Barcelona) ;
Vilardell Rigau, Pau (Hospital Universitari de Girona Doctor Josep Trueta) ;
Vila-Olives, Rosa (Hospital Universitari Vall d'Hebron) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Arzamendi, Dabit (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ferreira-Gonzalez, Ignacio (Hospital Universitari Vall d'Hebron) ;
Mirabet Pérez, Sonia (Universitat Autònoma de Barcelona. Departament de Medicina)
Aims: Despite numerous trials on revascularization in patients with heart failure (HF) and ischaemic left ventricular (LV) dysfunction, its role remains unsettled. Guideline-directed medical therapy (GDMT) for HF has shown benefits on outcomes. [...]
2025 - 10.1002/ejhf.3463
European Journal of Heart Failure, Vol. 27, Num. 3 (March 2025) , p. 598-605
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2026-03-19
14:12 |
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13 p, 529.8 KB |
Strengthening resilience to emerging vector-borne diseases in Europe : lessons learnt from countries facing endemic transmission
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Alcayna, Tilly (Red Cross Red Crescent Climate Centre) ;
Almuedo-Riera, Alex (Hospital Clínic i Provincial de Barcelona) ;
Antoniou, Christiana (Ministry of Health (Nicòsia, Xipre)) ;
Bartumeus, Frederic (Institució Catalana de Recerca i Estudis Avançats) ;
Bueno-Marí, Rubén (Universitat de València) ;
Hamid, Nurulhusna Ab (Ministry of Health (Malaysia)) ;
Michaelakis, Antonios (Benaki Phytopathological Institute) ;
Maciel-de-Freitas, Rafael (Instituto Oswaldo Cruz) ;
Montalvo Porro, Tomas (Institut de Recerca Sant Pau) ;
Muñoz, Jose (Universitat de Barcelona) ;
Palmer, John R. B. (Universitat Pompeu Fabra) ;
Lowe, Rachel (Institució Catalana de Recerca i Estudis Avançats) ;
E.C. Charnley, Gina (Imperial College London) ;
Badolo, Athanase (Université Joseph Ki-Zerbo) ;
Lee Boodram, Laura (The Caribbean Public Health Agency) ;
Codeço, Claudia (Programa de Computação Cientifica) ;
Codeço Coelho, Flavio (Fundação Getulio Vargas) ;
Costa, Federico (Instituto de Saúde Coletiva. Universidade Federal da Bahia) ;
Cox, Horace (The Caribbean Public Health Agency) ;
Haddad, Nabil (American University of Beirut) ;
Kittayapong, Pattamaporn (Mahidol University) ;
Korukluoğlu, Gülay (Ankara Bilkent City Hospital) ;
Sauleda Oliveras, Silvia (Universitat Autònoma de Barcelona. Banc de Sang i Teixits) ;
Barboza Pizard, Carlos Jesús (Ministerio de Salud Pública de Uruguay) ;
Ribeiro, Guilherme S. (Universidade Federal da Bahia) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Emerging vector-borne diseases (VBDs) are a major public health concern worldwide. Climate change, environmental degradation and globalisation have led to an expansion in the range of many vectors and an erosion of transmission barriers, increasing human exposure to new pathogens and the risk for emerging VBD outbreaks. [...]
2025 - 10.1016/j.lanepe.2025.101271
The Lancet Regional Health - Europe, Vol. 53 (June 2025) , art. 101271
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2026-03-19
14:12 |
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8 p, 1.0 MB |
Effectiveness of a nurse training intervention in the emergency department to improve the diagnosis and treatment of stemi patients : EDUCAMI study
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Berga Congost, Gemma (Institut de Recerca Sant Pau) ;
Brugaletta, Salvatore (Hospital Clínic i Provincial de Barcelona) ;
Valverde Bernal, Jonatan (Institut de Recerca Sant Pau) ;
Torralbas Ortega, Jordi (Institut de Recerca Sant Pau) ;
García Picart, Joan (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Arzamendi, Dabit (Institut de Recerca Sant Pau) ;
Puig Campmany, Mireia (Institut de Recerca Sant Pau) ;
Garcimartin, Paloma (Hospital del Mar (Barcelona, Catalunya)) ;
Berrocal Comalat, Mariona (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Mena Mejías, Sonia (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Muñoz Millán, Lorena (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Rodriguez Evangelista, Selma (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Ruiz Gabalda, J. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Jiménez Kockar, Marcelo (Institut de Recerca Sant Pau) ;
Martínez Momblán, Ma. Antonia (Universitat de Barcelona) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Clinical practice guidelines for acute coronary syndrome recommend an interval between electrocardiogram (ECG) and balloon of <60 min in patients attending the emergency department (ED) of a hospital with primary angioplasty capacity. [...]
2025 - 10.1016/j.hrtlng.2025.01.006
Heart and Lung, Vol. 70 (January 2025) , p. 305-312
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2026-03-19
13:15 |
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13 p, 1.2 MB |
Triplet systemic therapy for hormone-sensitive prostate cancer : a critical review with a multidisciplinary approach
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Zapatero, Almudena (Hospital Universitario de la Princesa (Madrid)) ;
Alonso-Gordoa, Teresa (Hospital Universitario Ramón y Cajal (Espanya, Madrid)) ;
Rodríguez Antolín, Alfredo (Hospital Universitario 12 de Octubre (Madrid)) ;
Couñago, Felipe (Universidad Europea de Madrid) ;
Borque-Fernando, Ángel (Hospital Universitario Miguel Servet (Saragossa)) ;
Maroto Rey, Pablo (Institut de Recerca Sant Pau) ;
Sanmamed, Noelia (Hospital Clínico San Carlos (Madrid)) ;
Domínguez Esteban, Mario (Hospital Universitario Marqués de Valdecilla (IDIVAL)) ;
López Valcárcel, Marta (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Manneh, Ray (Society of Oncology and Hematology of Cesar) ;
Sala-González, Núria (Hospital Universitari de Girona Doctor Josep Trueta) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
This article aims to critically evaluate the evidence for triplet therapy consisting of androgen deprivation therapy (ADT), docetaxel and a second-generation androgen receptor pathway inhibitor ([ARPI]; abiraterone, enzalutamide, darolutamide or apalutamide) in patients with metastatic hormone-sensitive prostate cancer (mHSPC), and what this evidence reveals regarding the use of these treatments in clinical practice. [...]
2025 - 10.3389/or.2025.1599292
Oncology Reviews, Vol. 19 (2025) , art. 1599292
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2026-03-19
11:12 |
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13 p, 1.5 MB |
Co-infections during SARS-CoV-2 infection in hematologic patients and cell therapy recipients in the omicron era : a Spanish hematopoietic stem cell transplantation and cell therapy group study
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Chorão, Pedro (Hospital Universitari i Politècnic La Fe (València)) ;
Heras, Inmaculada (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Aiello, Francesco (Hospital Clínic i Provincial de Barcelona) ;
Garcia-Gutierrez, Valentín (Hospital Universitario Ramón y Cajal (Madrid)) ;
Espigado, Ildefonso (Universidad de Sevilla) ;
González-Santillana, Clara (Hospital de Fuenlabrada (Madrid)) ;
Hernández-Rivas, José Ángel (Hospital Universitario Infanta Leonor) ;
Roldán-Pérez, Alicia (Universidad Europea de Madrid) ;
Labrador, Jorge (Hospital Universitario de Burgos) ;
Vázquez, Lourdes (Hospital Universitario de Salamanca) ;
Martino Bofarull, Rodrigo (Institut de Recerca Sant Pau) ;
López-Jiménez, Javier (Hospital Universitario Ramón y Cajal (Madrid)) ;
Cedillo Cedillo, Angel (Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH-TC) office (Madrid)) ;
Solano, Carlos (Universitat de València) ;
García Cadenas, Irene (Institut de Recerca Sant Pau) ;
Piñana, José Luis (INCLIVA Institut d'Investigació Sanitària) ;
Avendaño, Alex (Hospital Universitario de Salamanca) ;
Mico-Cerdá, Mireia (INCLIVA Institut d'Investigació Sanitària) ;
Arrufat Bel, Ana (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Olave, Maria T. (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Acera Gómez, Marina (Hospital Universitario de Salamanca) ;
Cuesta-Casas, María Ángeles (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Villalba, Marta (Instituto de Investigación Sanitaria La Fe) ;
Garcia-Vidal, Carolina (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Although SARS-Cov-2 outcomes have improved in the Omicron era, the synergistic or additive effects between SARS-CoV-2 Omicron variants and other microbiological agents in adult hematologic patients have been little explored. [...]
2025 - 10.1186/s12879-025-11302-w
BMC Infectious diseases, Vol. 25, Num. 1 (December 2025) , p. 944
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2026-03-19
11:12 |
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3 p, 337.6 KB |
Oral glucocorticoid patterns use in moderate to severe active SLE : insights from the Spanish SPOCS data
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Rua Figueroa, Íñigo (Complejo Hospitalario Doctor Negrin) ;
Cervera, Ricard (Hospital Clínic i Provincial de Barcelona) ;
Freire-González, Mercedes (Hospital Universitario de A Coruña) ;
Turrión Nieves, Ana Isabel (Hospital Universitario de Salamanca) ;
Cortés Hernández, Josefina (Hospital Universitari Vall d'Hebron) ;
Calvo Alén, Jaime (Arabako Unibertsitate Ospitalea (Vitoria, País Basc)) ;
Lozano-Rivas, Nuria (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ;
Ortego-Centeno, Norberto (Hospital de Especialidades San Cecilio) ;
Ding, Bo (AstraZeneca Sweden) ;
Galvez-Fernandez, Marta (AstraZeneca Farmacéutica Spain) ;
Pego-Reigosa, José María (Instituto de Investigación Sanitaria Galicia Sur) ;
Espinosa, Gerard (Hospital Clínic i Provincial de Barcelona) ;
Barilaro, Giuseppe (Hospital Clínic i Provincial de Barcelona) ;
Millán, Ana Milena (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Magallares López, Berta (Institut de Recerca Sant Pau) ;
Castellvi, Ivan (Institut de Recerca Sant Pau) ;
Barbado Ajo, Julia (Hospital Universitario Rio Hortega de Valladolid) ;
Salman-Monte, Tarek Carlos (Hospital del Mar (Barcelona, Catalunya)) ;
Díaz Encarnación, Montserrat Mercedes (Institut de Recerca Sant Pau) ;
Bahamontes-Rosa, Noemí (AstraZeneca Farmacéutica Spain) ;
Ríos-Garcés, Roberto (Hospital Clínic i Provincial de Barcelona) ;
Pino-Montes, Javier del (Hospital Universitario de Salamanca) ;
Hernández Madrid, José V. (Hospital Universitario de Salamanca) ;
Martínez-González, Olga (Hospital Universitario de Salamanca) ;
Atanes Sandoval, Antonio (Hospital Universitario de A Coruña (CHUAC)) ;
De Toro Santos, Francisco Javier (Hospital Universitario de A Coruña) ;
Graña, Jenaro (Hospital Universitario de A Coruña) ;
Sánchez Cano, Daniel (Hospital Universitario San Cecilio (Granada)) ;
de la Hera Fernández, Francisco Javier (Hospital Universitario San Cecilio (Granada)) ;
de Dios Jiménez de Aberasturi, Juan Ramón (Hospital de Araba) ;
Martínez Ferrin, Javier José (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
2025 - 10.1136/lupus-2025-001597
Lupus science & medicine, Vol. 12, Num. 2 (22 2025) , art. e001597
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2026-03-18
14:12 |
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12 p, 2.9 MB |
CHIT1 and DDAH1 levels relate to amyloid-related imaging abnormalities risk profile in Alzheimer's disease patients
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Hok-A-Hin, Yanaika S. (Vrije Universiteit Amsterdam) ;
van der Flier, Wiesje M. (Vrije Universiteit Amsterdam) ;
Barkhof, Frederik (Vrije Universiteit Amsterdam) ;
del Campo, Marta (Fundació Pasqual Maragall) ;
Bejanin, Alexandre (Institut de Recerca Sant Pau) ;
Alcolea, Daniel (Institut de Recerca Sant Pau) ;
Teunissen, Charlotte E. (Amsterdam University Medical Center (UMC)) ;
Vermunt, Lisa (Amsterdam University Medical Center (UMC)) ;
Oosthoek, Marlies (Amsterdam University Medical Center (UMC)) ;
Vijverberg, Everard G.B. (Vrije Universiteit Amsterdam) ;
Blujdea, Elena R. (Amsterdam University Medical Center (UMC)) ;
Veld, Sjors G.J.G.In't (Amsterdam University Medical Center (UMC)) ;
Pucheu Avilés, Martín (Amsterdam University Medical Center (UMC)) ;
Zsadanyi, Sara E. (Institut de Recerca Sant Pau) ;
Visser, Allerdien (Amsterdam University Medical Center (UMC)) ;
Schut, Martijn C. (Amsterdam University Medical Center (UMC)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Amyloid-related imaging abnormalities (ARIA) are a common and potentially dangerous side effect in anti-amyloid therapies, creating a need for tools to assess ARIA risk. Several patient factors have been linked to ARIA; namely the presence of microbleeds (MBL), APOE E4 carriership (APOE4), and extremely low CSF Aβ42 concentrations (A). [...]
2025 - 10.1186/s13195-025-01799-3
Alzheimer's research & therapy, Vol. 17, Num. 1 (December 2025) , p. 169
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