2026-07-31
14:12 |
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16 p, 17.2 MB |
Neural synaptic vesicle autoimmunity following aerosolized porcine neural tissue exposure : insights into autoimmune inflammatory polyradiculoneuropathy
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Paramasivan, Naveen K. (Mayo Clinic College of Medicine) ;
Hrstka, Sybil C. (Mayo Clinic College of Medicine) ;
Lleixà, Cinta (Institut de Recerca Sant Pau) ;
Querol, Luis (Institut de Recerca Sant Pau) ;
Dubey, Divyanshu (Mayo Clinic College of Medicine) ;
Hinson, Shannon R. (Mayo Clinic College of Medicine) ;
Gupta, Pranjal (Mayo Clinic College of Medicine) ;
Dyck, P. James B. (Mayo Clinic College of Medicine) ;
Lennon, Vanda A. (Mayo Clinic College of Medicine) ;
Lachance, Daniel H. (Mayo Clinic College of Medicine) ;
Knight, Andrew M. (Mayo Clinic College of Medicine) ;
Rezk, Mohamed (Mayo Clinic College of Medicine) ;
Karsten, Carley (Mayo Clinic College of Medicine) ;
LaFrance-Corey, Reghann G. (Mayo Clinic College of Medicine) ;
Staff, Nathan P. (Mayo Clinic College of Medicine) ;
Wu, Jack (Mayo Clinic College of Medicine) ;
Klein, Christopher J. (Mayo Clinic College of Medicine) ;
Zekeridou, Anastasia (Mayo Clinic College of Medicine) ;
McKeon, Andrew (Mayo Clinic College of Medicine) ;
Pittock, Sean J. (Mayo Clinic College of Medicine) ;
Dasari, Surendra (Mayo Clinic College of Medicine) ;
Mills, John R. (Mayo Clinic College of Medicine) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Between 2006 and 2008, cases of occupational inflammatory polyradiculoneuropathy (OIPN) were identified among U. S. swine abattoir workers exposed to aerosolized porcine neural tissue. While the clinical features of this occupational polyradiculoneuropathy/polyradiculopathy have been described, its immunologic basis remained unclear. [...]
2025 -  10.1016/j.ebiom.2025.106053
EBioMedicine, Vol. 122 (December 2025) , art. 106053
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2026-07-31
11:13 |
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14 p, 787.7 KB |
Comparative Effectiveness and Durability of Biologics Through 24 Months for Patients with Moderate-to-Severe Psoriasis : Results from the International, Observational Psoriasis Study of Health Outcomes (PSoHO)
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Pinter, Andreas (University Hospital of Frankfurt (Alemanya)) ;
Brnabic, Alan (Eli Lilly and Company) ;
Puig Sanz, Lluís (Institut de Recerca Sant Pau) ;
Carrascosa, José Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Megna, Matteo (University of Naples Federico II (Itàlia)) ;
Sabatino, Silvia (Eli Lilly and Company) ;
Trovato, Emanuele (Università degli Studi di Siena) ;
Boyé, Thierry (Sainte Anne Military Hospital) ;
De La Torre, Inmaculada (Eli Lilly and Company) ;
Maul, Julia-Tatjana (University of Zurich) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Introduction: The Psoriasis Study of Health Outcomes (PSoHO) is an international, prospective, non-interventional study investigating the comparative effectiveness and durability of biologic treatments for patients with moderate-to-severe psoriasis (PsO) over 36 months. [...]
2025 - 10.1007/s13555-025-01494-z
Dermatology and Therapy, Vol. 15, Num. 10 (October 2025) , p. 2819-2832
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2026-07-31
11:13 |
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17 p, 1.8 MB |
Long-Term Effectiveness and Safety of Bimekizumab in Patients with Moderate to Severe Hidradenitis Suppurativa Under Real Clinical Practice Conditions : The Importance of Combined Treatment in Hurley III Patients and Potential Factors Associated with Complete Response
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Fernández-Crehuet, Pablo (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Garbayo Salmons, Patricia (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Martorell, Antonio (Hospital de Manises (València)) ;
Sahuquillo-Torralba, Antonio (Instituto de Investigación Sanitaria (IIS) La Fe) ;
Soto-Moreno, Alberto (Hospital Universitario Virgen de las Nieves (Granada)) ;
Botella-Estrada, Rafael (Universitat de València) ;
Vilarrasa-Rull, Eva (Institut de Recerca Sant Pau) ;
Molina-Leyva, Alejandro (Hospital Universitario Virgen de las Nieves (Granada)) ;
Mansilla-Polo, Miguel (Instituto de Investigación Sanitaria (IIS) La Fe) ;
García-Moronta, Carmen (Hospital Universitario Virgen de las Nieves (Granada)) ;
Pons-Benavent, Martí (Hospital Virgen de los Lirios) ;
Aguilar-González, Lucía (Hospital Universitario Puerta del Mar (Cadis, Andalusia)) ;
Jiménez-Gallo, David (Hospital Universitario Puerta del Mar (Cadis, Andalusia)) ;
Alcalá-García, Rebeca (Hospital de Sagunto) ;
Martin-Ezquerra, Gemma (Hospital del Mar (Barcelona, Catalunya)) ;
Mahiques-Santos, Laura (Consorci Hospitalari Provincial de Castelló) ;
Alfageme Roldan, Fernando (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Escutia-Muñoz, Begoña (Instituto de Investigación Sanitaria (IIS) La Fe) ;
Fayos-Gregori, Rafael (Instituto de Investigación Sanitaria (IIS) La Fe) ;
Sánchez-Gutiérrez, Irene (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Introduction: Hidradenitis suppurativa (HS) is a debilitating, chronic inflammatory skin disease that severely impacts patients' quality of life. Bimekizumab, the first dual inhibitor of interleukin (IL)-17A and IL-17F, has shown efficacy in phase 3 clinical trials and is currently approved for moderate-to-severe HS. [...]
2025 - 10.1007/s13555-025-01521-z
Dermatology and Therapy, Vol. 15, Num. 11 (November 2025) , p. 3267-3283
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2026-07-31
11:13 |
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14 p, 531.6 KB |
Retrospective Cohort Study of Intrapericardial Cisplatin for Risk Reduction of Malignant Pericardial Effusion Recurrence
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Muñoz-Carrillo, Francisco Javier (Hospital Clínic i Provincial de Barcelona) ;
Cascos, Enric (Hospital Clínic i Provincial de Barcelona) ;
Castro Rebollo, Pedro (Hospital Clínic i Provincial de Barcelona) ;
Fernández-Méndez, Sara (Hospital Clínic i Provincial de Barcelona) ;
Font, C. (Hospital Clínic i Provincial de Barcelona) ;
Monge-Escartín, Inés (Hospital Clínic i Provincial de Barcelona) ;
Padrosa Pulido, Joan (Hospital Clínic i Provincial de Barcelona) ;
Reguart, Noemi (Hospital Clínic i Provincial de Barcelona) ;
Téllez, Adrián (Hospital Clínic i Provincial de Barcelona) ;
Tuca, Albert (EAPS Fundació La Caixa) ;
Zamora-Martínez, Carles (Hospital Clínic i Provincial de Barcelona) ;
Amorós-Reboredo, Patrícia (Institut de Recerca Sant Pau) ;
Marco-Hernández, Javier (Hospital Clínic i Provincial de Barcelona) ;
Reyes, Roxana (Hospital Clínic i Provincial de Barcelona) ;
Pesantez, David (Hospital Clínic i Provincial de Barcelona) ;
Carreras, Gemma (Hospital Clínic i Provincial de Barcelona) ;
González-Aguado, Laura (Hospital Clínic i Provincial de Barcelona) ;
Grafia, Ignacio (Hospital Clínic i Provincial de Barcelona) ;
Llavata, Lucía (Hospital Clínic i Provincial de Barcelona) ;
Viladot, Margarita (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Malignant pericardial effusion (MPE) is a life-threatening condition in patients with cancer, with common recurrences after simple pericardiocentesis. Consequently, the intrapericardial instillation of sclerosing or cytotoxic agents has been explored, with limited evidence from small studies with different methodologies. [...]
2025 - 10.3390/curroncol32100568
Current Oncology, Vol. 32, Num. 10 (October 2025) , p. 568
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2026-07-31
11:13 |
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15 p, 1.8 MB |
Association of noradrenaline dose with mortality in critically ill patients : a systematic review and dose-response meta-analysis
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Blaser, Annika Reintam (University of Tartu) ;
Moreno, Rui (Universidade da Beira Interior) ;
Rhodes, Andrew (St. George's University Hospitals NHS Foundation Trust) ;
Singer, Mervyn (University College London) ;
Reinikainen, Matti (Kuopio University Hospital and University of Eastern Finland) ;
Delamarre, Louis (Gui de Chauliac Hospital - Montpellier University Hospital) ;
Hollenberg, Steven M. (Emory University School of Medicine) ;
Lobo, Suzana M. (Hospital de Base) ;
Rezende, Ederlon (The Hospital do Servidor Público Estadual - IAMSPE) ;
Ranzani, Otavio T. (Institut de Recerca Sant Pau) ;
Lakbar, Inès (University Hospital of Montpellier (França)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Noradrenaline is currently the first-line vasopressor in treatment of circulatory failure. Its dose reflects illness severity, and together with dopamine, dobutamine and adrenaline, it is used in the Sequential Organ Failure Assessment (SOFA) score to grade cardiovascular dysfunction. [...]
2025 - 10.1186/s13054-025-05717-9
Critical care, Vol. 29, Num. 1 (December 2025) , p. 498
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2026-07-31
11:13 |
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21 p, 2.5 MB |
Electrophysiological Phenotyping of hiPSC-Derived Atrial Cardiomyocytes Using Automated Patch-Clamp : A Platform for Studying Atrial Inherited Arrhythmias
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Jiménez-Sábado, Verónica (Institut de Recerca Sant Pau) ;
Babini, Hosna (Simon Fraser University (Canadà)) ;
Claydon, Thomas W. (Simon Fraser University (Canadà)) ;
Madsen, Leif Hove (Institut de Recerca Sant Pau) ;
Tibbits, Glen F. (University of British Columbia) ;
Ruben, Peter C. (Simon Fraser University) ;
Accili, Eric A. (University of British Columbia) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Highlights: What are the main findings? Developed an optimized dissociation and recording protocol enabling reliable automated patch-clamp recordings of major atrial ionic currents (I, I, I, I, I, and I) in hiPSC-derived atrial cardiomyocytes. [...]
2025 - 10.3390/cells14241941
Cells, Vol. 14, Num. 24 (December 2025) , art. 1941
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2026-07-30
13:13 |
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22 p, 2.0 MB |
Endocrine-disrupting chemicals exposure : cardiometabolic health risk in humans
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Mauricio, Didac (Institut de Recerca Sant Pau) ;
Ma, Cheng-Xu (The First Hospital of Lanzhou University) ;
Ma, Xiao-Ni (The First Hospital of Lanzhou University) ;
Li, Hong-Li (The First Hospital of Lanzhou University) ;
Fu, Song-Bo (The First Clinical Medicine College of Lanzhou University) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Endocrine-disrupting chemicals (EDCs) are exogenous compounds that interfere with hormone action, and growing evidence suggests that human exposure to certain EDCs may increase the risk of obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD). [...]
2025 - 10.1186/s12933-025-02938-8
Cardiovascular diabetology, Vol. 24, Num. 1 (December 2025) , p. 381
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2026-07-30
13:13 |
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11 p, 1.4 MB |
Role of Spatially Fractionated Radiotherapy (LATTICE) Treatment in Inoperable Bulky Soft-Tissue Sarcomas
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Majercakova, Katarina (Institut de Recerca Sant Pau) ;
Tejedor, Natalia (Institut de Recerca Sant Pau) ;
Isern Verdum, Josep (Institut de Recerca Sant Pau) ;
Vivancos, Helena (Institut de Recerca Sant Pau) ;
Rojas Cordero, Jady Vivian (Institut de Recerca Sant Pau) ;
González López, José Antonio (Institut de Recerca Sant Pau) ;
Bagué Rosell, Sílvia (Institut de Recerca Sant Pau) ;
Peiró Ibañez, Ana M. (Institut de Recerca Sant Pau) ;
Sebio, Ana (Institut de Recerca Sant Pau) ;
Sancho-Pardo, Gemma (Institut de Recerca Sant Pau) ;
Vila capel, Antonio (Institut de Recerca Sant Pau) ;
Mancera Soto, Miriam (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Gómez de Segura Melcón, Guillermo (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Hernández-Jover, Diana (Institut de Recerca Sant Pau) ;
Rabi Mitre, Saba (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: The clinical outcome of inoperable sarcoma patients treated with LATTICE (LRT) is limited and therefore the objective of our study was to report treatment response, overall survival (OS), local-recurrence free survival (LRFS) and toxicity. [...]
2025 - 10.3390/cancers17040624
Cancers, Vol. 17, Num. 4 (February 2025) , p. 624
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2026-07-30
12:13 |
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11 p, 1.5 MB |
Prevalence of Fms-Like Tyrosine Kinase 3 (FLT3) Mutations in Patients With Acute Myeloid Leukaemia : A Systematic Literature Review and Meta-Analysis
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Daver, Naval G. (The University of Texas MD Anderson Cancer Center) ;
Robinson, Noah Jamie (Astellas Pharma A.G.) ;
Pandya, Bhavik J. (Astellas Pharma. Inc.) ;
Sierra, Jorge (Institut de Recerca Sant Pau) ;
Lewis, Juliana F.M. (Astellas Pharma. Inc.) ;
Pierre-Louis, Bosny (Astellas Pharma. Inc.) ;
Monir, Sayma (Astellas Pharma Europe B.V.) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Fms-like tyrosine kinase 3 (FLT3) mutations are associated with poor prognosis in patients with acute myeloid leukaemia (AML). Aims: We conducted a systematic literature review and meta-analyses of studies reporting FLT3 mutation prevalence in patients with AML. [...]
2025 - 10.1002/cam4.71205
Cancer Medicine, Vol. 14, Num. 18 (September 2025) , art. e71205
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2026-07-30
10:13 |
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8 p, 818.6 KB |
Recommendations for the use of biomarkers for the management of adults with sepsis : a scoping review and critical appraisal
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Mateos-Haro, Miriam (Universidad de Granada) ;
Garcia-Santa-Vinuela, Ana (Hospital Universitario Ramón y Cajal (Madrid)) ;
Solà Arnau, Ivan (Institut de Recerca Sant Pau) ;
Gordo Vidal, Federico (Universidad Francisco de Vitoria (Pozuelo de Alarcón, Madrid)) ;
Martin Delgado, Maria Cruz (Universidad Francisco de Vitoria (Pozuelo de Alarcón, Madrid)) ;
López Alcalde, Jesús (Hospital Universitario Ramón y Cajal (Madrid)) ;
Zamora, Javier (Hospital Universitario Ramón y Cajal (Madrid)) ;
Molano-Franco, Daniel (Hospital de San José/Hospital Infantil de San José (Bogotà, Colòmbia)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Objective A synthesis and appraisal of the recommendations for biomarkers in practice guidelines concerning sepsis is required to consolidate evidence-based practice. We generated an evidence gap map (EGM) on the use of biomarkers for managing adults with sepsis. [...]
2025 - 10.1136/bmjopen-2024-090922
BMJ open, Vol. 15, Num. 7 (June 2025) , art. e090922
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