Impact of stress on brain morphology : Insights into structural biomarkers of stress-related disorders
Cardoner, Narcís (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Andero Galí, Raül (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Cano, Marta (Institut de Recerca Sant Pau)
Marin-Blasco, Ignacio (Universitat Autònoma de Barcelona. Institut de Neurociències)
Porta-Casteras, Daniel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Serra-Blasco, Maria (Institut Català d'Oncologia)
Via, Esther (Institut de Recerca Sant Joan de Déu)
Vicent-Gil, Muriel (Institut de Recerca Sant Pau)
Portella, Maria J. (Institut de Recerca Sant Pau)

Date:	2024
Abstract:	Exposure to acute and chronic stress has a broad range of structural effects on the brain. The brain areas commonly targeted in the stress response models include the hippocampus, the amygdala, and the prefrontal cortex. Studies in patients suffering from the so-called stress-related disorders -embracing post-traumatic stress, major depressive and anxiety disorders- have fairly replicated animal models of stress response -particularly the neuroendocrine and the inflammatory models- by finding alterations in different brain areas, even in the early neurodevelopment. Therefore, this narrative review aims to provide an overview of structural neuroimaging findings and to discuss how these studies have contributed to our knowledge of variability in response to stress and the ulterior development of stress-related disorders. There are a gross number of studies available but neuroimaging research of stress-related disorders as a single category is still in its infancy. Although the available studies point at particular brain circuitries involved in stress and emotion regulation, the pathophysiology of these abnormalities -involving genetics, epigenetics and molecular pathways-, their relation to intraindividual stress responses -including personality characteristics, self-perception of stress conditions…-, and their potential involvement as biomarkers in diagnosis, treatment prescription and prognosis are discussed.
Grants:	Instituto de Salud Carlos III AC19/00077 Instituto de Salud Carlos III AC19/00088
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Ressenya ; recerca ; Versió publicada
Subject:	Basolateral amygdala ; Brain morphology ; HPA. ; PTSD ; Stress response systems
Published in:	Current Neuropharmacology, Vol. 22 Núm. 5 (2024) , p. 935-962, ISSN 1875-6190

DOI: 10.2174/1570159X21666230703091435
PMID: 37403395

28 p, 4.4 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
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