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| Pàgina inicial > Articles > Articles publicats > Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy |
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Hospital Universitari i Politècnic La Fe (València)) (Hospital Universitario Reina Sofía (Còrdova, Espanya)) (Hospital Universitario Rey Juan Carlos (Madrid)) (Hospital Universitario Rey Juan Carlos (Madrid)) (Instituto de Salud Carlos III)
| Data: | 2018 |
| Resum: | The mitochondrial DNA (mtDNA) seems to influence in a large number of diseases, including HIV infection. Moreover, there is a substantial inter-individual variability in the CD4+ recovery in HIV-infected patients on combination antiretroviral therapy (cART). Our study aimed to analyze the association between mtDNA haplogroups and CD4+ recovery in HIV-infected patients on cART. This is a retrospective study of 324 naïve cART patients with CD4+ < 200 cells/mm 3, who were followed-up during 24 months after initiating cART. All patients had undetectable HIV viral load during the follow-up. Besides, we included 141 healthy controls. MtDNA genotyping was performed by using Sequenom's MassARRAY platform. The primary outcome variable was the slope of CD4+ recovery. Patients were stratified into two groups by the median slope value of CD4+ (9. 65 CD4+ cells/mm 3 /month). Logistic regression analyses were performed to calculate the odds of CD4+ recovery according to mtDNA haplogroups. Our study included European HIV-infected patients within the N macro-cluster. The baseline values of CD4+ T-cells were similar between groups of patients stratified by the P50th of the slope of CD4+ T-cells recovery. Patients in the low CD4+ T-cells recovery group were older (p = 0. 001), but this variable was included in the multivariate models. When we analyzed the frequencies of mtDNA haplogroups, no significant differences between HIV-infected individuals and healthy controls were found. We did not find any significant association between mtDNA haplogroups and the slope of CD4+ T-cells recovery by linear regression analysis. However, Patients carrying haplogroup H had a higher odds of having a better CD4+ recovery (> 9. 65 CD4+ cells/mm 3 /month) than patients without haplogroup H (p = 0. 032). The adjusted logistic regression showed that patients carrying haplogroup H had a higher likelihood of achieving a CD4+ recovery > 9. 65 CD4+ cells/mm 3 /month [adjusted odds ratio (aOR) = 1. 75 (95% CI = 1. 04; 2. 95); p = 0. 035]. European mitochondrial haplogroup H was associated with the improved CD4+ recovery in HIV-infected patients starting cART with CD4+ < 200 cells/mm 3. |
| Ajuts: | Ministerio de Economía y Competitividad RD12/0017/0024 Ministerio de Economía y Competitividad RD12/0017/0031 Ministerio de Economía y Competitividad RD16/0025/0013 Ministerio de Economía y Competitividad CD14/00002 Ministerio de Economía y Competitividad CP14/00198 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | HIV ; Mitochondria ; Haplogroups ; Mtdna ; Immune reconstitution ; Cart |
| Publicat a: | Journal of translational medicine, Vol. 16 (december 2018) , ISSN 1479-5876 |
