Associations between epicardial adipose tissue, subclinical atherosclerosis and high-density lipoprotein composition in type 1 diabetes
Colom, Cristina (Institut d'Investigació Biomèdica Sant Pau)
Viladés Medel, David (Institut d'Investigació Biomèdica Sant Pau)
Pérez-Cuellar, Montserrat (Institut d'Investigació Biomèdica Sant Pau)
Leta, Rubén (Institut d'Investigació Biomèdica Sant Pau)
Rivas-Urbina, Andrea (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Carreras, Gemma (Universitat Autònoma de Barcelona. Departament de Medicina)
Ordoñez Llanos, Jorge 1952- (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Pérez Pérez, Antonio (Universitat Autònoma de Barcelona. Departament de Medicina)
Sanchez-Quesada, Jose Luis (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)

Data:	2018
Resum:	The pathophysiology of cardiovascular complications in people with type 1 diabetes (T1DM) remains unclear. An increase in epicardial adipose tissue (EAT) and alterations in the composition of high-density lipoprotein (HDL) are associated with coronary artery disease, but information on its relationship in T1DM is very limited. Our aim was to determine the association between EAT volume, subclinical atherosclerosis, and HDL composition in type 1 diabetes. Seventy-two long-term patients with T1DM without clinical atherosclerosis were analyzed. EAT volume and subclinical atherosclerosis were measured using cardiac computed tomography angiography. EAT was adjusted according to body surface to obtain an EAT index (iEAT). HDL composition was determined. The mean iEAT was 40. 47 ± 22. 18 cc/m 2. The bivariate analysis showed positive associations of the iEAT with gender, age, hypertension, dyslipidemia, smoking, body mass index, waist circumference, insulin dose, and triglyceride (P < 0. 05). The iEAT correlated positively with small HDL, increased content of apolipoprotein (apo)A-II and apoC-III, and decreased content of apoE and free cholesterol. Multiple linear regression showed that age, apoA-II content in HDL, and waist circumference were independently associated with the iEAT. Fifty percent of the patients presented subclinical atherosclerotic lesions. These patients had a higher iEAT, and their HDL contained less cholesterol and more apoA-II and lipoprotein-associated phospholipase A2 than patients without subclinical atherosclerosis. Alterations in the composition of HDL in TIDM are associated with increased iEAT and the presence of subclinical atherosclerosis. We propose that these abnormalities of HDL composition could be useful to identify T1DM patients at highest cardiovascular risk. The online version of this article (10. 1186/s12933-018-0794-9) contains supplementary material, which is available to authorized users.
Ajuts:	Instituto de Salud Carlos III FIS PI13/00364 Instituto de Salud Carlos III PI16/00471 Instituto de Salud Carlos III CIBERDEM (CB07/08/0016)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Type 1 diabetes ; Epicardial adipose tissue ; Coronary atherosclerosis ; High-density lipoprotein ; Apolipoproteins
Publicat a:	Cardiovascular diabetology, Vol. 17 (december 2018) , ISSN 1475-2840

DOI: 10.1186/s12933-018-0794-9
PMID: 30526614

10 p, 885.5 KB

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