Mesenchymal stem cells for cardiac repair : are the actors ready for the clinical scenario?
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Mirabel, Clémentine (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Vives Armengol, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina)
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)

Date:	2017
Abstract:	For years, sufficient progress has been made in treating heart failure following myocardial infarction; however, the social and economic burdens and the costs to world health systems remain high. Moreover, treatment advances have not resolved the underlying problem of functional heart tissue loss. In this field of research, for years we have actively explored innovative biotherapies for cardiac repair. Here, we present a general, critical overview of our experience in using mesenchymal stem cells, derived from cardiac adipose tissue and umbilical cord blood, in a variety of cell therapy and tissue engineering approaches. We also include the latest advances and future challenges, including good manufacturing practice and regulatory issues. Finally, we evaluate whether recent approaches hold potential for reliable translation to clinical trials.
Grants:	Ministerio de Economía y Competitividad SAF2014-59892 Ministerio de Economía y Competitividad RD16/0011/0006 Ministerio de Economía y Competitividad RD16/ 0011/0028 Ministerio de Economía y Competitividad CB16/11/00403 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014-SGR-699
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cardiac adipose tissue ; Cardiac repair ; Cell therapy ; Good manufacturing practice ; Mesenchymal stem cells ; Tissue engineering ; Umbilical cord blood
Published in:	Stem cell research & therapy, Vol. 8 (october 2017) , ISSN 1757-6512

DOI: 10.1186/s13287-017-0695-y
PMID: 29078809

11 p, 682.2 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles