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Pàgina inicial > Articles > Articles publicats > FGF-23/Vitamin D Axis in Type 1 Diabetes : |
Data: | 2015 |
Resum: | To investigate the usefulness of Fibroblast Growth Factor 23 (FGF-23) and vitamin D as possible biomarkers of pre-clinical atherosclerosis, assessed as arterial stiffness (AS), in a group of subjects with type 1 diabetes (T1DM) and no previous cardiovascular events. 68 T1DM patients and 68 age- and sex-matched controls were evaluated for 1) age, sex, diabetes duration, physical activity, smoking, alcohol intake, BMI, blood pressure, fasting plasma glucose, HbA, estimated glomerular filtration rate (eGFR) and lipid profile; 2) microvascular complications; 3) blood concentrations of FGF-23 and mineral metabolism parameters (calcium, phosphate, parathyroid hormone (PTH) and 25-hydroxy-vitamin D (25(OH)D)); 4) AS, assessed as aortic pulse wave velocity (aPWV); and 5) low-grade inflammation (hsCRP, IL-6, sTNFαR1, sTNFαR2) and endothelial dysfunction (ED) markers (ICAM-1, VCAM-1, E-Selectin). Patients with T1DM had higher aPWV compared with controls (p<0. 001), but they did not present differences in 25(OH)D (70. 3(50. 4-86. 2)nmol/L vs. 70. 7(59. 7-83. 0)nmol/L; p = 0. 462) and in FGF-23 plasma concentrations (70. 1(38. 4-151. 9)RU/mL vs. 77. 6(51. 8-113. 9)RU/mL; p = 0. 329). In T1DM patients, higher concentrations of FGF-23 were positively associated with aPWV after adjusting for eGFR and classical cardiovascular risk factors (model 1: ß = 0. 202, p = 0. 026), other mineral metabolism parameters (model 2: ß = 0. 214, p = 0. 015), microvascular complications, low-grade inflammation and ED markers (model 3: ß = 0. 170, p = 0. 045). Lower 25(OH)D concentrations were also associated with higher aPWV after adjusting for all the above-mentioned factors (model 3: ß = -0. 241, p = 0. 015). We conclude that both FGF-23 plasma concentrations (positively) and 25(OH)D serum concentrations (negatively) are associated with AS in patients with T1DM and no previous cardiovascular events. |
Ajuts: | Ministerio de Ciencia e Innovación PS09/01360 Instituto de Salud Carlos III PI12/00954 Fundació la Marató de TV3 08141 Ministerio de Sanidad y Consumo CB07/08/0012 Ministerio de Economía y Competitividad SAF2012-36186 Ministerio de Ciencia e Innovación CP10/00438 Ministerio de Economía y Competitividad CM12/00044 Ministerio de Ciencia e Innovación CP10/00438 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Publicat a: | PloS one, Vol. 10 (october 2015) , ISSN 1932-6203 |
12 p, 238.0 KB |