HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels
López-Dupla, Miguel (Hospital Universitari Joan XXIII de Tarragona)
Maymó-Masip, Elsa (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Martínez, Esteban (Hospital Clínic i Provincial de Barcelona)
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau)
Leal, Manuel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Peraire, Joaquim (Hospital Universitari Joan XXIII de Tarragona)
Viladés, Consuelo (Hospital Universitari Joan XXIII de Tarragona)
Veloso, Sergi (Hospital Universitari Joan XXIII de Tarragona)
Arnedo, Mireia (Hospital Clínic i Provincial de Barcelona)
Ferrando-Martínez, Sara (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Beltrán-Debón, Raúl (Hospital Universitari Joan XXIII de Tarragona. Institut d'Investigació Sanitària Pere Virgili)
Alba, Verónica (Hospital Universitari Joan XXIII de Tarragona. Institut d'Investigació Sanitària Pere Virgili)
Gatell, Josep Mª (Hospital Clínic i Provincial de Barcelona)
Vendrell, Joan (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Vidal, Francesc (Hospital Universitari Joan XXIII de Tarragona)
Chacón, Matilde R. (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Universitat Autònoma de Barcelona

Date:	2015
Abstract:	Obesity and HIV-1/HAART-associated lipodystrophy syndrome (HALS) share clinical, pathological and mechanistic features. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that plays an important role in obesity and related diseases. We sought to explore the relationship between HALS and circulating levels of soluble (s) TWEAK and its scavenger receptor sCD163. This was a cross-sectional multicenter study of 120 HIV-1-infected patients treated with a stable HAART regimen; 56 with overt HALS and 64 without HALS. Epidemiological and clinical variables were determined. Serum levels of sTWEAK and sCD163 levels were measured by ELISA. Results were analyzed with Student's t -test, Mann-Whitney U and χ 2 test. Pearson and Spearman correlation were used to estimate the strength of association between variables. Circulating sTWEAK was significantly decreased in HALS patients compared with non-HALS patients (2. 81±0. 2 vs. 2. 94±0. 28 pg/mL, p = 0. 018). No changes were observed in sCD163 levels in the studied cohorts. On multivariate analysis, a lower log sTWEAK concentration was independently associated with the presence of HALS (OR 0. 027, 95% CI 0. 001-0. 521, p = 0. 027). HALS is associated with decreased sTWEAK levels.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-250 Instituto de Salud Carlos III PI13/0796 Instituto de Salud Carlos III PI14/0465 Instituto de Salud Carlos III RD12/0017/0001 Instituto de Salud Carlos III RD12/0017/0005 Instituto de Salud Carlos III RD17/0017/0022 Instituto de Salud Carlos III RD17/0017/0029 Instituto de Salud Carlos III INT11/240 Instituto de Salud Carlos III INT12/282 Instituto de Salud Carlos III INT12/383 Ministerio de Sanidad, Servicios Sociales e Igualdad EC11-293
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 10 (december 2015) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0144789
PMID: 26658801

13 p, 274.5 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles