Structural Integrity of the Contralesional Hemisphere Predicts Cognitive Impairment in Ischemic Stroke at Three Months
Dacosta Aguayo, Rosalia (University of the Basque Country UPV/EHU, San Sebastian, Spain)
Graña, Manuel (University of the Basque Country UPV/EHU, San Sebastian, Spain)
Fernández-Andújar, Marina (Universitat de Barcelona)
López-Cancio, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Cáceres, Cynthia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bargalló, Núria (Hospital Clínic i Provincial de Barcelona)
Barrios, Maite (Universitat de Barcelona. Departament de Metodologia de les Ciències del Comportament)
Clemente, Immaculada (Universitat de Barcelona)
Monserrat, Pere Toran (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Sas, Maite Alzamora (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Auer, Tibor (MRC Cognition and Brain Sciences Unit, Cambridge, England)
Mataró, Maria (Universitat de Barcelona)
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2014
Abstract:	After stroke, white matter integrity can be affected both locally and distally to the primary lesion location. It has been shown that tract disruption in mirror's regions of the contralateral hemisphere is associated with degree of functional impairment. Fourteen patients suffering right hemispheric focal stroke (S) and eighteen healthy controls (HC) underwent Diffusion Weighted Imaging (DWI) and neuropsychological assessment. The stroke patient group was divided into poor (SP; n = 8) and good (SG; n = 6) cognitive recovery groups according to their cognitive improvement from the acute phase (72 hours after stroke) to the subacute phase (3 months post-stroke). Whole-brain DWI data analysis was performed by computing Diffusion Tensor Imaging (DTI) followed by Tract Based Spatial Statistics (TBSS). Assessment of effects was obtained computing the correlation of the projections on TBSS skeleton of Fractional Anisotropy (FA) and Radial Diffusivity (RD) with cognitive test results. Significant decrease of FA was found only in right brain anatomical areas for the S group when compared to the HC group. Analyzed separately, stroke patients with poor cognitive recovery showed additional significant FA decrease in several left hemisphere regions; whereas SG patients showed significant decrease only in the left genu of corpus callosum when compared to the HC. For the SG group, whole brain analysis revealed significant correlation between the performance in the Semantic Fluency test and the FA in the right hemisphere as well as between the performance in the Grooved Pegboard Test (GPT) and theTrail Making Test-part A and the FA in the left hemisphere. For the SP group, correlation analysis revealed significant correlation between the performance in the GPT and the FA in the right hemisphere.
Grants:	Ministerio de Ciencia e Innovación PSI2009-11519 Ministerio de Ciencia e Innovación BES-2010-031833 Ministerio de Ciencia e Innovación TIN2011-23823
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 9 (january 2014) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0086119
PMID: 24475078

11 p, 3.3 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles