Prosthetic Shoulder Joint Infection by Cutibacterium acnes : Does Rifampin Improve Prognosis? A Retrospective, Multicenter, Observational Study
Vilchez, Helem (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Escudero-Sánchez, Rosa (Hospital Universitario Ramón y Cajal (Madrid))
Fernandez-Sampedro, Marta (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Murillo Rubio, Oscar (Hospital Universitari de Bellvitge)
Auñón, Álvaro (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz)
Rodriguez-Pardo, Dolors (Hospital Universitari Vall d'Hebron)
Jover-Sáenz, Alfredo (Hospital Arnau de Vilanova (Lleida, Catalunya))
del Toro López, María Dolores (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Rico Nieto, Alicia (Hospital Universitario La Paz (Madrid))
Falgueras, Luis (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Praena-Segovia, Julia (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Guío, Laura (Hospital Universitario de Cruces (Barakaldo, País Basc))
Iribarren, José A. (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Lora-Tamayo, Jaime (Hospital Universitario 12 de Octubre (Madrid))
Benito, Natividad (Institut d'Investigació Biomèdica Sant Pau)
Morata, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Ramírez Rosales, Antonio (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Riera, Melchor (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	This retrospective, multicenter observational study aimed to describe the outcomes of surgical and medical treatment of C. acnes -related prosthetic joint infection (PJI) and the potential benefit of rifampin-based therapies. Patients with C. acnes -related PJI who were diagnosed and treated between January 2003 and December 2016 were included. We analyzed 44 patients with C. acnes -related PJI (median age, 67. 5 years (IQR, 57. 3-75. 8)); 75% were men. The majority (61. 4%) had late chronic infection according to the Tsukayama classification. All patients received surgical treatment, and most antibiotic regimens (43. 2%) included β-lactam. Thirty-four patients (87. 17%) were cured; five showed relapse. The final outcome (cure vs. relapse) showed a nonsignificant trend toward higher failure frequency among patients with previous prosthesis (OR: 6. 89; 95% CI: 0. 80-58. 90) or prior surgery and infection (OR: 10. 67; 95% IC: 1. 08-105. 28) in the same joint. Patients treated with clindamycin alone had a higher recurrence rate (40. 0% vs. 8. 8%). Rifampin treatment did not decrease recurrence in patients treated with β-lactams. Prior prosthesis, surgery, or infection in the same joint might be related to recurrence, and rifampin-based combinations do not seem to improve prognosis. Debridement and implant retention appear a safe option for surgical treatment of early PJI.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cutibacterium acnes ; Prosthetic joint infection ; Surgical and medical treatment
Published in:	Antibiotics, Vol. 10 (april 2021) , ISSN 2079-6382

DOI: 10.3390/antibiotics10050475
PMID: 33919103

13 p, 642.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles