Cause of Death in Heart Failure Based on Etiology : Long-Term Cohort Study of All-Cause and Cardiovascular Mortality
Spitaleri, Giosafat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Zamora, Elisabet (Universitat Autònoma de Barcelona. Departament de Medicina)
Cediel, Germán (Universitat Autònoma de Barcelona. Departament de Medicina)
Codina, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Santiago Vacas, Evelyn (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Domingo, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina)
Santesmases, Javier (Universitat Autònoma de Barcelona. Departament de Medicina)
Diez-Quevedo, Crisanto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Troya, Maria Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Boldo Alcaine, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Altimir Losada, Salvador (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
González Fernández, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)

Date:	2022
Abstract:	We assessed differences in long-term all-cause and cardiovascular (CV) mortality in heart failure (HF) outpatients based on the etiology of HF. Consecutive patients admitted to the HF Clinic from August 2001 to September 2019 (N = 2587) were considered for inclusion. HF etiology was divided into ischemic heart disease (IHD), dilated cardiomyopathy (DCM), hypertensive heart disease, alcoholic cardiomyopathy, drug-induced cardiomyopathy (DICM), valvular heart disease, and hypertrophic cardiomyopathy. All-cause death and CV death were the primary end points. Among 2387 patients included in the analysis (mean age 66. 5 ± 12. 5 years, 71. 3% men), 1317 deaths were recorded (731 from CV cause) over a maximum follow-up of 18 years (median 4. 1 years, interquartile range (IQR) 2-7. 8). Considering IHD as the reference, only DCM had a lower risk of all-cause death (adjusted hazard ratio (aHR) 0. 68, 95% confidence interval (CI) 0. 56-0. 83, p < 0. 001), and only DICM had a higher risk of all-cause death (aHR 1. 47, 95% CI 1. 02-2. 11, p = 0. 04). However, almost all etiologies had a significantly lower risk of CV death than IHD. Among the studied HF etiologies, DCM and DICM have the lowest and highest risk of all-cause death, respectively, whereas IHD has the highest adjusted risk of CV death.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Heart failure with reduced ejection fraction ; Heart failure with preserved ejection fraction ; Heart failure etiology
Published in:	Journal of clinical medicine, Vol. 11 Núm. 3 (january 2022) , ISSN 2077-0383

DOI: 10.3390/jcm11030784
PMID: 35160236

10 p, 895.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles