Transcutaneous electrical neuromodulation of the cervical spinal cord depends both on the stimulation intensity and the degree of voluntary activity for training. A pilot study
Kumru, Hatice (Institut Germans Trias i Pujol. Institut Guttmann)
Rodríguez-Cañón, María (Institut Germans Trias i Pujol. Institut Guttmann)
Edgerton, Victor (Institut Germans Trias i Pujol. Institut Guttmann)
García, Loreto (Institut Germans Trias i Pujol. Institut Guttmann)
Flores, África (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Soriano Crespo, Ignasi (Institut Germans Trias i Pujol. Institut Guttmann)
Opisso, Eloy (Institut Germans Trias i Pujol. Institut Guttmann)
Gerasimenko, Yury (University of Louisville)
Navarro, X. (Xavier) (Institut Germans Trias i Pujol. Institut Guttmann)
García Alias, Guillermo (Institut Germans Trias i Pujol. Institut Guttmann)
Vidal, Joan (Institut Germans Trias i Pujol. Institut Guttmann)

Date:	2021
Abstract:	Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation offers promise in improving hand function. However, it is still unknown which stimulus intensity or which muscle force level could be better for this improvement. Nine healthy individuals received the following interventions: (i) eEmc intensities at 80%, 90% and 110% of abductor pollicis brevis motor threshold combined with hand training consisting in 100% handgrip strength; (ii) hand training consisting in 100% and 50% of maximal handgrip strength combined with 90% eEmc intensity. The evaluations included box and blocks test (BBT), maximal voluntary contraction (MVC), F wave persistency, F/M ratio, spinal and cortical motor evoked potentials (MEP), recruitment curves of spinal MEP and cortical MEP and short-interval intracortical inhibition. The results showed that: (i) 90% eEmc intensity increased BBT, MVC, F wave persistency, F/M ratio and cortical MEP recruitment curve; 110% eEmc intensity increased BBT, F wave persistency and cortical MEP and recruitment curve of cortical MEP; (ii) 100% handgrip strength training significantly modulated MVC, F wave persistency, F/M wave and cortical MEP recruitment curve in comparison to 50% handgrip strength. In conclusion, eEmc intensity and muscle strength during training both influence the results for neuromodulation at the cervical level.
Grants:	Ministerio de Economía y Competitividad AC16/00034 Instituto de Salud Carlos III PI19/01680
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cervical spinal cord ; Hand training ; Intensity effect ; Muscle strength effect ; Neuromodulation ; Transcutaneous spinal cord stimulation
Published in:	Journal of clinical medicine, Vol. 10 Núm. 15 (january 2021) , p. 3278, ISSN 2077-0383

DOI: 10.3390/jcm10153278
PMID: 34362062

16 p, 2.2 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles