Register-based information on thyroid diseases in Europe : lessons and results from the EUthyroid collaboration
Møllehave, Line Tang (Bispebjerg and Frederiksberg Hospital)
Eliasen, Marie Holm (Bispebjerg and Frederiksberg Hospital Health)
Linneberg, Allan (University of Copenhagen)
Moreno-Reyes, Rodrigo (Université Libre de Bruxelles)
Ivanova, Ludmila B. (Faculty of Medicine)
Kusić, Zvonko (School of Medicine)
Erlund, Iris (Department of Government Services)
Ittermann, Till (Institute for Community Medicine)
Nagy, Endre V (Division of Endocrinology)
Gunnarsdottir, Ingibjorg (University of Iceland)
Arbelle, Jonathan Eli (Goldman School of Medicine)
Troen, Aaron Milton (The Hebrew University of Jerusalem)
Pīrāgs, Valdis (University of Latvia)
Dahl, Lisbeth (Institute of Marine Research (Noruega))
Hubalewska-Dydejczyk, Alicja (Jagiellonian University, Medical College)
Trofimiuk-Müldner, Malgorzata (Jagiellonian University, Medical College)
de Castro, João Jacome (Armed Forces Hospital (Portugal))
Marcelino, Mafalda (Armed Forces Hospital (Portugal))
Gaberšček, Simona (University Medical Centre Ljubljana)
Zaltel, Katja (University Medical Centre Ljubljana)
Puig Domingo, Manuel (Institut Germans Trias i Pujol)
Vila, Lluís (Hospital de Sant Joan Despí Moisès Broggi)
Manousou, Sofia (Frölunda Specialist Hospital)
Nyström, Helena Filipsson (Wallenberg Centre of Molecular and Translational Medicine)
Zimmermann, Michael Bruce (ETH Zurich)
Mullan, Karen R. (Belfast Health and Social Care Trust)
Woodside, Jayne Valerie (Queen's University Belfast)
Völzke, Henry (University Medicine Greifswald)
Thuesen, Betina Heinsbæk (Bispebjerg and Frederiksberg Hospital)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Registers of diagnoses and treatments exist in different forms in the European countries and are potential sources to answer important research questions. Prevalence and incidence of thyroid diseases are highly dependent on iodine intake and, thus, iodine deficiency disease prevention programs. We aimed to collect European register data on thyroid outcomes to compare the rates between countries/regions with different iodine status and prevention programs. Register-based cross-sectional study. National register data on thyroid diagnoses and treatments were requested from 23 European countries/regions. The provided data were critically assessed for suitability for comparison between countries/regions. Sex- and age-standardized rates were calculated. Register data on ≥1 thyroid diagnoses or treatments were available from 22 countries/regions. After critical assessment, data on medication, surgery, and cancer were found suitable for comparison between 9, 10, and 13 countries/regions, respectively. Higher rates of antithyroid medication and thyroid surgery for benign disease and lower rates of thyroid hormone therapy were found for countries with iodine insufficiency before approx. 2001, and no relationship was observed with recent iodine intake or prevention programs. The collation of register data on thyroid outcomes from European countries is impeded by a high degree of heterogeneity in the availability and quality of data between countries. Nevertheless, a relationship between historic iodine intake and rates of treatments for hyper- and hypothyroid disorders is indicated. This study illustrates both the challenges and the potential for the application of register data of thyroid outcomes across Europe.
Grants:	European Commission. Horizon 2020 634453
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Europe ; Registries ; Iodine ; Thyroid diseases
Published in:	Endocrine Connections, Vol. 11 (january 2022) , ISSN 2049-3614

DOI: 10.1530/EC-21-0525
PMID: 35044931

11 p, 752.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles