Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study
Pérez-Recio, Sandra (Institut d'Investigació Biomèdica de Bellvitge)
Pallarès, Natàlia (Institut d'Investigació Biomèdica de Bellvitge)
Grijota-Camino, Maria D. (Institut d'Investigació Biomèdica de Bellvitge)
Sánchez-Montalvá, Adrián (Hospital Universitari Vall d'Hebron)
Barcia, Laura (Complejo Hospitalario Universitario de Pontevedra)
Campos-Gutiérrez, Silvia (Hospital Universitario de Canarias (La Laguna))
Pomar, Virginia (Institut d'Investigació Biomèdica Sant Pau)
Rabuñal-Rey, Ramón (Hospital Universitario Lucus Augusti (Lugo))
Balcells, María Elvira (Pontificia Universidad Católica de Chile)
Gazel, Denzil (Gaziantep Üniversitesi)
Montiel, Natalia (Hospital Costa del Sol (Marbella))
Vicente, Diego (Donostiako Unibertsitate Ospitalea)
Goić-Barišić, Ivana (Sveučilište u Splitu)
Schön, Thomas (Linköpings universitat)
Paues, Jakob (Linköpings universitat)
Mareković, Ivana (Klinički bolnički centar Zagreb)
Cacho-Calvo, Juana (Hospital Universitario de Getafe (Madrid))
Barac, Aleksandra (Univerzitet u Beogradu)
Goletti, Delia (Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani-IRCCS)
García-Gasalla, Mercedes (Institut d'Investigació Sanitària Illes Balears)
Barcala, José María (Hospital Universitario de Jerez (Jerez de la Frontera))
Tórtola Fernández, María Teresa (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Anibarro, Luis (Complejo Hospitalario Universitario de Pontevedra)
Suárez-Toste, Isabel (Hospital Universitario de Canarias (La Laguna))
Moga, Esther (Institut d'Investigació Biomèdica Sant Pau)
Gude-González, María José (Hospital Universitario Lucus Augusti (Lugo))
Naves, Rodrigo (Universidad de Chile)
Karsligil, Tekin (Gaziantep Üniversitesi)
Martin-Peñaranda, Tania (Donostiako Unibertsitate Ospitalea)
Stevanovic, Goran (Univerzitet u Beogradu)
Trigo, Matilde (Complejo Hospitalario Universitario de Pontevedra)
Rubio, Verónica (Institut d'Investigació Biomèdica Sant Pau)
Karaoǧlan, Ilkay (Gaziantep Üniversitesi)
Bayram, Nazan (Gaziantep Üniversitesi)
Alcaide, Fernando (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental)
Tebé, Cristian (Institut d'Investigació Biomèdica de Bellvitge)
Santin, Miguel (Universitat de Barcelona. Departament de Ciències Clíniques)

Date:	2021
Abstract:	We investigated whether the difference of antigen tube 2 (TB2) minus antigen tube 1 (TB1) (TB22TB1) of the QuantiFERON-TB gold plus test, which has been postulated as a surrogate for the CD81 T-cell response, could be useful in identifying recent tuberculosis (TB) exposure. We looked at the interferon gamma (IFN-g) responses and differences in TB2 and TB1 tubes for 686 adults with QFT-plus positive test results. These results were compared among groups with high (368 TB contacts), low (229 patients with immune-mediated inflammatory diseases [IMID]), and indeterminate (89 asylum seekers or people from abroad [ASPFA]) risks of recent TB exposure. A TB22TB1 value. 0. 6 IU_ml21 was deemed to indicate a true difference between tubes. In the whole cohort, 13. 6%, 10. 9%, and 11. 2% of cases had a TB2. TB1 result in the contact, IMID, and ASPFA groups, respectively (P = 0. 591). The adjusted odds ratios (aORs) for an association between a TB22TB1 result of. 0. 6 IU_ml21 and risk of recent exposure versus contacts were 0. 71 (95% confidence interval [CI], 0. 31 to 1. 61) for the IMID group and 0. 86 (95% CI, 0. 49 to 1. 52) for the ASPFA group. In TB contact subgroups, 11. 4%, 15. 4%, and 17. 7% with close, frequent, and sporadic contact had a TB2. TB1 result (P = 0. 362). The aORs versus the close subgroup were 1. 29 (95% CI, 0. 63 to 2. 62) for the frequent subgroup and 1. 55 (95% CI, 0. 67 to 3. 60) for the sporadic subgroup. A TB22TB1 difference of. 0. 6 IU_ml21 was not associated with increased risk of recent TB exposure, which puts into question the clinical potential as a proxy marker for recently acquired TB infection.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	QuantiFERON-TB gold plus ; Diagnosis ; Latent tuberculosis infection ; Tuberculosis-specific CD8 T cells
Published in:	Microbiology Spectrum, Vol. 9 Núm. 3 (december 2021) , p. e00972-21, ISSN 2165-0497

DOI: 10.1128/Spectrum.00972-21
PMID: 34756079

10 p, 1.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles