Diplopia is frequent and associated with motor and non-motor severity in parkinson's disease : Results from the COPPADIS cohort at 2-year follow-up
Santos García, Diego (Complejo Hospitalario Universitario de A Coruña)
Naya Ríos, Lucía (Complejo Hospitalario Universitario de A Coruña)
de Deus Fonticoba, Teresa (Complejo Hospitalario Universitario de Ferrol)
Cores Bartolomé, Carlos (Complejo Hospitalario Universitario de A Coruña)
García Roca, Lucía (Complejo Hospitalario Universitario de A Coruña)
Feal Painceiras, Maria (Complejo Hospitalario Universitario de A Coruña)
Martínez Miró, Cristina (Complejo Hospitalario Universitario de A Coruña)
Canfield Medina, H (Complejo Hospitalario Universitario de Ferrol)
Jesús, Silvia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Aguilar Barberà, Miquel (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Pastor, Pau (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Cosgaya, Marina (Hospital Clínic i Provincial de Barcelona)
García Caldentey, Juan (Centro Neurológico Oms 42)
Caballol, Nuria (Hospital de Sant Joan Despí Moisès Broggi)
Legarda, Inés (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Hernández-Vara, Jorge (Hospital Universitari Vall d'Hebron)
Cabo-Lopez, Iria (Complejo Hospitalario Universitario de Pontevedra)
López Manzanares, Lydia (Hospital Universitario de la Princesa (Madrid))
Gonzalez-Aramburu, Isabel (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Ávila, Asunción (Hospital General de l'Hospitalet)
Gómez Mayordomo, Víctor (Hospital Clínico San Carlos (Madrid))
Nogueira, Victor (Hospital Da Costa)
Puente, Víctor (Hospital del Mar (Barcelona, Catalunya))
Dotor, Julio (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Borrué, Carmen (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes))
Solano Vila, Berta (Institut Català de la Salut)
Álvarez Sauco, María (Hospital General Universitario de Elche)
Vela, Lydia (Hospital Universitario Fundación Alcorcón)
Escalante, Sonia (Hospital de Tortosa Verge de la Cinta)
Cubo, Esther (Complejo Asistencial Universitario de Burgos)
Carrillo Padilla, Francisco (Hospital Universitario de Canarias (La Laguna))
Martínez-Castrillo, Juan Carlos (Hospital Universitario Ramón y Cajal (Madrid))
Sánchez Alonso, Pilar (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Alonso Losada, Maria G. (Hospital Álvaro Cunqueiro (Vigo))
López Ariztegui, Nuria (Complejo Hospitalario de Toledo)
Gastón, Itziar (Complejo Hospitalario de Navarra)
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau)
Blázquez Estrada, Marta (Hospital Universitario Central de Asturias)
Seijo, Manuel (Complejo Hospitalario Universitario de Pontevedra)
Ruíz Martínez, Javier (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Valero, Caridad (Hospital Arnau de Vilanova (València))
Kurtis, Mónica (Hospital Ruber Internacional)
Fàbregues-Boixar i Nebot, Oriol de (Hospital Universitari Vall d'Hebron)
González Ardura, Jessica (Hospital Universitario de Cabueñes (Gijón))
Alonso Redondo, Ruben (Hospital Universitario Lucus Augusti (Lugo))
Ordás, Carlos (Hospital Universitario Rey Juan Carlos (Madrid))
López Díaz, Luis M. (Complejo Hospitalario Universitario de Ourense)
McAfee, Darrian (University of Maryland School of Medicine)
Martinez-Martin, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Mir, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Background and objective: Diplopia is relatively common in Parkinson's disease (PD) but is still understudied. Our aim was to analyze the frequency of diplopia in PD patients from a multicenter Spanish cohort, to compare the frequency with a control group, and to identify factors associated with it. Patients and Methods: PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30 days follow-up (V2) from 35 centers of Spain from the COPPADIS cohort were included in this longitudinal prospective study. The patients and controls were classified as "with diplopia" or "without diplopia" according to item 15 of the Non-Motor Symptoms Scale (NMSS) at V0, V1 (1-year ± 15 days), and V2 for the patients and at V0 and V2 for the controls. Results: The frequency of diplopia in the PD patients was 13. 6% (94/691) at V0 (1. 9% in controls [4/206]; p < 0. 0001), 14. 2% (86/604) at V1, and 17. 1% (86/502) at V2 (0. 8% in controls [1/124]; p < 0. 0001), with a period prevalence of 24. 9% (120/481). Visual hallucinations at any visit from V0 to V2 (OR = 2. 264; 95%CI, 1. 269-4. 039; p = 0. 006), a higher score on the NMSS at V0 (OR = 1. 009; 95%CI, 1. 012-1. 024; p = 0. 015), and a greater increase from V0 to V2 on the Unified Parkinson's Disease Rating Scale-III (OR = 1. 039; 95%CI, 1. 023-1. 083; p < 0. 0001) and Neuropsychiatric Inventory (OR = 1. 028; 95%CI, 1. 001-1. 057; p = 0. 049) scores were independent factors associated with diplopia (R = 0. 25; Hosmer and Lemeshow test, p = 0. 716). Conclusions: Diplopia represents a frequent symptom in PD patients and is associated with motor and non-motor severity.
Grants:	Ministerio de Economía y Competitividad PI18-01898
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Changes ; Motor ; Parkinson's disease ; Phenotype ; PIGD ; Tremor
Published in:	Diagnostics, Vol. 11 Núm. 12 (december 2021) , p. 2380, ISSN 2075-4418

DOI: 10.3390/diagnostics11122380
PMID: 34943619

14 p, 2.4 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles