Clinical and structural brain correlates of hypomimia in early-stage Parkinson's disease
Sampedro, Frederic (Institut d'Investigació Biomèdica Sant Pau)
Martinez-Horta, Saul (Institut d'Investigació Biomèdica Sant Pau)
Horta, Andrea (Institut d'Investigació Biomèdica Sant Pau)
Grothe, Michael J. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Labrador-Espinosa, Miguel A. (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Jesús, Silvia (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Adarmes-Gómez, A.D (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Carrillo, Fátima (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Puig-Davi, Arnau (Institut d'Investigació Biomèdica Sant Pau)
Roldan-Lora, Florinda (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Aguilar Barberà, Miquel (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Pastor, Pau (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Escalante, Sonia (Hospital de Tortosa Verge de la Cinta)
Solano Vila, Berta (Institut Català de la Salut)
Cots-Foraster, Anna (Institut Català de la Salut)
Ruiz-Martínez, Javier (Biodonostia Osasun Ikerketako Institutura (País Basc))
Carrillo Padilla, Francisco (Hospital Universitario de Canarias (La Laguna))
Pueyo-Morlans, Mercedes (Hospital Universitario de Canarias (La Laguna))
Gonzalez-Aramburu, Isabel (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Infante-Ceberio, Jon (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Hernández-Vara, Jorge (Hospital Universitari Vall d'Hebron)
Fàbregues-Boixar i Nebot, Oriol de (Hospital Universitari Vall d'Hebron)
de Deus Fonticoba, Teresa (Complejo Hospitalario Universitario de Ferrol)
Ávila, Asunción (Consorci Sanitari Integral. Hospital General de L'Hospitalet. L'Hospitalet de Llobregat)
Martínez-Castrillo, Juan Carlos (Hospital Universitario Ramón y Cajal (Madrid))
Bejr-kasem, Helena (Institut d'Investigació Biomèdica Sant Pau)
Campolongo, Antonia (Institut d'Investigació Biomèdica Sant Pau)
Pascual-Sedano, Berta María (Institut d'Investigació Biomèdica Sant Pau)
Martínez-Martín, Pablo (Centro de Investigacion Biomedica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED). Instituto de Salud Carlos III)
Santos García, Diego (Complejo Hospitalario Universitario de A Coruña)
Mir, Pablo (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
García Ruiz, Pedro J (Departamento de Neurologia. Fundación Jimenez Diaz)
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Background and purpose: Reduced facial expression of emotions is a very frequent symptom of Parkinson's disease (PD) and has been considered part of the motor features of the disease. However, the neural correlates of hypomimia and the relationship between hypomimia and other non-motor symptoms of PD are poorly understood. Methods: The clinical and structural brain correlates of hypomimia were studied. For this purpose, cross-sectional data from the COPPADIS study database were used. Age, disease duration, levodopa equivalent daily dose, Unified Parkinson's Disease Rating Scale part III (UPDRS-III), severity of apathy and depression and global cognitive status were collected. At the imaging level, analyses based on gray matter volume and cortical thickness were used. Results: After controlling for multiple confounding variables such as age or disease duration, the severity of hypomimia was shown to be indissociable from the UPDRS-III speech and bradykinesia items and was significantly related to the severity of apathy (β = 0. 595; p < 0. 0001). At the level of neural correlates, hypomimia was related to motor regions brodmann area 8 (BA 8) and to multiple fronto-temporo-parietal regions involved in the decoding, recognition and production of facial expression of emotions. Conclusion: Reduced facial expressivity in PD is related to the severity of symptoms of apathy and is mediated by the dysfunction of brain systems involved in motor control and in the recognition, integration and expression of emotions. Therefore, hypomimia in PD may be conceptualized not exclusively as a motor symptom but as a consequence of a multidimensional deficit leading to a symptom where motor and non-motor aspects converge.
Note:	Altres ajuts: acords transformatius de la UAB
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Hypomimia ; Neural ; Neuroimage ; Non-motor symptoms ; Parkinson's disease
Published in:	European Journal of Neurology, 2022 , ISSN 1468-1331

DOI: 10.1111/ene.15513

9 p, 1.2 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles