Cognitive clusters in first-episode psychosis
Amoretti, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Rabelo-da-Ponte, Francisco Diego (Hospital de Clínicas de Porto Alegre (Brasil))
Rosa, Adriane (Department of Pharmacology. Postgraduate Program in Psychiatry and Behavioral Sciences. Universidade Federal do Rio Grande do Sul (UFRGS))
Mezquida, Gisela (Centro de Investigación Biomédica en Red de Salud Mental)
Sánchez-Torres, Ana Maria (IdiSNA. Navarra Institute for Health Research)
Fraguas, David (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Cabrera, Bibiana (Centro de Investigación Biomédica en Red de Salud Mental)
Lobo, Antonio (Instituto de Investigación Sanitaria de Aragón)
González-Pinto, Ana (Arabako Unibertsitate Ospitalea (Vitoria, País Basc))
Pina-Camacho, Laura (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Corripio, Iluminada (Institut d'Investigació Biomèdica Sant Pau)
Vieta, Eduard (Universitat de Barcelona)
Torrent, Carla (Universitat de Barcelona)
de la Serna, Elena (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Bergé Baquero, Daniel (Universitat Autònoma de Barcelona)
Bioque, Miquel (Centro de Investigación Biomédica en Red de Salud Mental)
Garriga, Marina (Universitat de Barcelona)
Serra-Navarro, Maria (Universitat de Barcelona)
Cuesta, Manuel J. (Instituto de Investigación Sanitaria de Navarra)
Bernardo, Miquel (Centro de Investigación Biomédica en Red de Salud Mental)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Impairments in a broad range of cognitive domains have been consistently reported in some individuals with first-episode psychosis (FEP). Cognitive deficits can be observed during the prodromal stage. However, the course of cognitive deficits is still unclear. The aim of this study was to identify cognitive subgroups over time and to compare their sociodemographic, clinical and functional profiles. A total of 114 patients with Schizophrenia Spectrum Disorders were included in the present study. We assessed subjects through psychiatric scales and eight neuropsychological tests at baseline and at two-year follow-up visit. We performed the Partition Around Medoids algorithm with all cognitive variables. Furthermore, we performed a logistic regression to identify the predictors related to the different cognitive clusters at follow-up. Two distinct subgroups were found: the first cluster characterized by cognitive impairment and a second cluster had relatively intact cognition in comparison with norms. Up to 54. 7% of patients with cognitive deficits at baseline tended to improve during the first two years of treatment. Patients with intact cognition at follow-up had a higher socioeconomic status, later age of onset, lower negative symptoms and a higher cognitive reserve (CR) at baseline. CR and age of onset were the baseline variables that predicted cognitive impairment. This research allows us to obtain a better understanding of the heterogeneous profile of psychotic disorders. Identifying the characteristics of patients who will present a cognitive impairment could improve early detection and intervention. These results suggest that enhancing CR could contribute to improving the course of the illness.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	First episode ; Cognitive reserve ; Cognition ; Neuropsychology ; Early intervention
Published in:	Schizophrenia Research, Vol. 237 (november 2021) , p. 31-39, ISSN 1573-2509

DOI: 10.1016/j.schres.2021.08.021
PMID: 34481203

9 p, 871.9 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles