Baseline Description of the Spanish Academy of Dermatology Infantile Haemangioma Nationwide Prospective Cohort. Comparison of Patients Treated with Propranolol in Routine Clinical Practice with Previous Pivotal Clinical Trial Data Descripción basal de la cohorte nacional prospectiva de hemangiomas infantiles de la Academia Española de Dermatología y Venereología. Comparación de los pacientes tratados con propranolol en la práctica clínica rutinaria y los datos del ensayo clínico pivotal previo
Cuenca-Barrales, Carlos (Instituto de Investigación Sanitaria de Granada)
Baselga Torres, Eulàlia (Clínica Dermik)
del Boz-González, Javier (Departamento de Dermatología. Hospital Costa del Sol. Marbella)
Vicente-Villa, Asunción (Departamento de Dermatología. Hospital Sant Joan de Déu)
Palencia-Pérez, Sara Isabel (Hospital Universitario 12 de Octubre (Madrid))
Campos-Domínguez, Minia (Hospital General Universitario Gregorio Marañón)
Valdivieso-Ramos, M. (Hospital Universitario Infanta Leonor)
Martín-Santiago, Ana (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Monserrat-García, Maria Teresa (Departamento de Dermatología. Hospital Viamed Santa Ángela de la Cruz)
Azon, Antoni (Hospital Universitari Sant Joan de Reus (Tarragona))
Feito-Rodríguez, Marta (Hospital Universitario La Paz (Madrid))
Domínguez-Cruz, Javier Jesús (Departamento de Dermatología. Hospital Viamed Santa Ángela de la Cruz)
Roé Crespo, Esther (Institut d'Investigació Biomèdica Sant Pau)
Salas-Márquez, Cristina (Hospital Costa del Sol (Marbella))
Giacaman, Aniza (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Lorente-Lavirgen, Ana Isabel (Hospital Viamed Santa Ángela de la Cruz. Departamento de Dermatología)
Quintana-Castanedo, Lucía (Hospital Universitario La Paz (Madrid))
de Vega-Martínez, Marina (Unidad de investigación. Fundación Piel Sana Academia Española de Dermatología y Venereología)
García-Doval, Ignacio (Complexo Hospitalario Universitario de Vigo)
Bernabéu-Wittel, José (Hospital Viamed Santa Ángela de la Cruz. Departamento de Dermatología)

Date:	2021
Abstract:	Background: There are several therapeutic options for infantile haemangiomas (IH). Propranolol is used according to a pivotal trial. We aimed to describe the characteristics of IH in clinical practice, including the therapies used, and to compare the characteristics of patients treated with propranolol with those of the trial to assess its external validity. Methods: Consecutive patients attending 12 Spanish hospitals from June 2016 to October 2019 were included (n = 601). Results: The mean age was 3. 9 (SD:1. 9) months, with a 2:1 female-to-male ratio. Most IHs were localized (82%, 495), superficial (64%, 383) and located in the face (25%, 157) and trunk (31%, 188). Median size was 17 (IR: 10-30) x 12 (IR: 7-20) mm. Complications were found in 16 (3%) patients. Treatment was initiated for 52% (311). Most patients received timolol (76%, 237); propranolol was reserved for complications or high-risk IHs. Aesthetic impairment was the main reason for starting therapy (64%, 199). Several characteristics of the patients and IHs treated with propranolol are similar to those of the pivotal clinical trial, but 1/3 of IHs did not reach the minimum diameter to meet the inclusion criteria, and important prognostic information was not reported. Conclusions: As most patients receive treatment for aesthetic impairment, there is a need to better understand the aesthetic results of therapies and to increase evidence on the use of timolol, which is currently the most common therapy. Propranolol is being used in a population generally similar to that of the trial; however, this statement cannot be definitely confirmed.
Note:	Altres ajuts: Fundación Piel Sana AEDV.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Castellà
Document:	Article ; recerca ; Versió publicada
Subject:	Haemangioma ; Capillary ; Cross-sectional studies ; Prospective studies ; Propranolol ; Timolol
Published in:	Actas Dermo-Sifiliograficas, Vol. 112 Núm. 9 (octubre 2021) , p. 806-816, ISSN 1578-2190

DOI: 10.1016/j.ad.2021.05.007
PMID: 34052200

11 p, 636.9 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles