Accelerated biological aging in COVID-19 patients
Cao, Xue (Department of Colorectal Surgery. The Sixth Affiliated Hospital. Sun Yat-sen University)
Li, Wenjuan (Department of Pulmonary and Critical Care Medicine. The Third Affiliated Hospital. Sun Yat-sen University)
Wang, Ting (Research & Development. Thermo Fisher Scientific Inc.)
Ran, Dongzhi (University of Arizona. Department of Pharmacology)
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Planas-Serra, Laura (Institut d'Investigació Biomèdica de Bellvitge)
Pujol, Aurora 1968- (Institut d'Investigació Biomèdica de Bellvitge)
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Wang, Xiaolin (Guangdong Institute of Gastroenterology. Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease. The Sixth Affiliated Hospital. Sun Yat-sen University)
Yu, Huichuan (Department of Colorectal Surgery. The Sixth Affiliated Hospital. Sun Yat-sen University)

Data:	2022
Resum:	Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous findings indicate that epigenetic age could be altered in viral infection. However, the epigenetic aging in COVID-19 has not been well studied. In this study, DNA methylation of the blood samples from 232 healthy individuals and 413 COVID-19 patients is profiled using EPIC methylation array. Epigenetic ages of each individual are determined by applying epigenetic clocks and telomere length estimator to the methylation profile of the individual. Epigenetic age acceleration is calculated and compared between groups. We observe strong correlations between the epigenetic clocks and individual's chronological age (r > 0. 8, p < 0. 0001). We also find the increasing acceleration of epigenetic aging and telomere attrition in the sequential blood samples from healthy individuals and infected patients developing non-severe and severe COVID-19. In addition, the longitudinal DNA methylation profiling analysis find that the accumulation of epigenetic aging from COVID-19 syndrome could be partly reversed at late clinic phases in some patients. In conclusion, accelerated epigenetic aging is associated with the risk of SARS-CoV-2 infection and developing severe COVID-19. In addition, the accumulation of epigenetic aging from COVID-19 may contribute to the post-COVID-19 syndrome among survivors.
Ajuts:	Fundació la Marató de TV3 565/C/2021
Nota:	Altres ajuts: National Natural Science Foundation of China (81902877, HY); Natural Science Foundation of Guangdong Province (2022A1515012656, HY; 2018A0303130303, HY); Program of Introducing Talents of Discipline to Universities, and the National Key Clinical Discipline (2012)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Aging ; COVID-19 ; DNA Methylation ; Epigenesis, Genetic ; Humans ; SARS-CoV-2
Publicat a:	Nature communications, Vol. 13 Núm. 1 (december 2022) , art. 2135, ISSN 2041-1723

DOI: 10.1038/s41467-022-29801-8
PMID: 35440567

7 p, 1.1 MB

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