visitant ::
identificació
|
|||||||||||||||
Cerca | Lliura | Ajuda | Servei de Biblioteques | Sobre el DDD | Català English Español |
Pàgina inicial > Articles > Articles publicats > Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese |
Data: | 2022 |
Resum: | High circulating concentrations of the gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) are significantly associated with the risk of obesity and type 2 diabetes (T2D). We aimed at evaluating the impact of glycemic control and bariatric surgery on circulating concentrations of TMAO and its microbiota-dependent intermediate, γ-butyrobetaine (γBB), in newly diagnosed T2D patients and morbidly obese subjects following a within-subject design. Based on HbA1c concentrations, T2D patients achieved glycemic control. However, the plasma TMAO and γBB concentrations were significantly increased, without changes in estimated glomerular filtration rate. Bariatric surgery was very effective in reducing weight in obese subjects. Nevertheless, the surgery reduced plasma γBB concentrations without affecting TMAO concentrations and the estimated glomerular filtration rate. Considering these results, an additional experiment was carried out in male C57BL/6J mice fed a Western-type diet for twelve weeks. Neither diet-induced obesity nor insulin resistance were associated with circulating TMAO and γBB concentrations in these genetically defined mice strains. Our findings do not support that glycemic control or bariatric surgery improve the circulating concentrations of TMAO in newly diagnosed T2D and morbidly obese patients. |
Ajuts: | Instituto de Salud Carlos III PI18-00164 Instituto de Salud Carlos III PI21-00140 Instituto de Salud Carlos III PI19-00136 Instituto de Salud Carlos III PI17-00232 Ministerio de Economía y Competitividad PI16-00471 Ministerio de Ciencia e Innovación PID2019-104367RB-100 Instituto de Salud Carlos III CM20/00033 Agencia Estatal de Investigación RYC-201722879 Instituto de Salud Carlos III CPII18/00004 Agencia Estatal de Investigación RYC-201722879 Agencia Estatal de Investigación RED2018-102799-T |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | SDG 3 - Good Health and Well-being |
Publicat a: | Diagnostics, Vol. 12 Núm. 11 (2022) , ISSN 2075-4418 |
878.1 KB |