 visitant ::
identificació
|
|||||||||||||||
|
Cerca | Lliura | Ajuda | Servei de Biblioteques | Sobre el DDD | Català English Español | |||||||||
| Pàgina inicial > Articles > Articles publicats > Abdominal obesity and dsyglycemia are risk factors for liver fibrosis progression in NAFLD subjects : |
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Universitat Autònoma de Barcelona. Departament de Medicina) (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) (Institut Català de la Salut. Centre d'Atenció Primària La Llagosta) (Universitat Autònoma de Barcelona. Departament de Medicina) (Institut Català de la Salut. Centre d'Atenció Primària Raval Sud (Barcelona, Catalunya)) (University of Florida) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) (Universitat Autònoma de Barcelona. Departament de Medicina)
| Data: | 2023 |
| Resum: | To investigate longitudinal changes in the liver stiffness measurement (LSM) in the general adult population without known liver disease and to describe its association with metabolic risk factors, with a special focus on subjects with non-alcoholic fatty liver disease (NAFLD) and dysglycemia. A longitudinal adult population-based cohort study was conducted in Catalonia. LSM was measured by transient elastography (TE) at baseline and follow-up (median: 4. 2 years). Subgroup with NAFLD and dysglycemia were analyzed. Moderate-to-advanced liver fibrosis was defined as LSM ≥8. 0 kPa and LSM ≥9. 2 kPa respectively. Among 1. 478 subjects evaluated, the cumulative incidence of LSM ≥8. 0 kPa and ≥9. 2 kPa at follow-up was 2. 8% and 1. 9%, respectively. This incidence was higher in NAFLD (7. 1% for LSM ≥8. 0 kPa and 5% for LSM ≥9. 2 kPa) and dysglycemia (6. 2% for LSM ≥8. 0 kPa and 4. 7% for LSM ≥9. 2 kPa) subgroups. In the global cohort, the multivariate analyses showed that dysglycemia, abdominal obesity and atherogenic dyslipidemia were significantly associated with progression to moderate-to-advanced liver fibrosis. Female sex was negatively associated. In subjects with NAFLD, abdominal obesity and dysglycemia were associated with changes in LSM to ≥8. 0 kPa and ≥9. 2 kPa at follow-up. A decline in LSM value to <8 kPa was observed in 64% of those subjects with a baseline LSM ≥8. 0 kPa. In this population study, the presence of abdominal obesity and dysglycemia were the main risk metabolic factors associated with moderate-to-advanced liver fibrosis development over time in general populations as well as in subjects with NAFLD. |
| Ajuts: | Ministerio de Economía y Competitividad PI11/0267 Ministerio de Economía y Competitividad PI14/00407 Ministerio de Economía y Competitividad PI16/00043 Instituto de Salud Carlos III PI21/00817 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Liver fibrosis ; NAFLD ; Transient elastography ; Abdominal obesity ; Dysglycemia ; General population |
| Publicat a: | Frontiers in endocrinology, Vol. 13 (january 2023) , ISSN 1664-2392 |
