Bisphenol a exposure and kidney diseases : Systematic review, meta-analysis and nhanes 03-16 study
Moreno-Gómez-toledano, R. (Universidad de Alcalá)
Arenas, M.I. (Universidad de Alcalá)
Vélez-Vélez, E. (Hospital Universitario Fundación Jiménez Díaz)
Coll, Elisabet (Institut d'Investigació Biomèdica Sant Pau)
Quiroga, B. (Hospital Universitario de la Princesa (Madrid))
Bover, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bosch, R.J. (Universidad de Alcalá)
Universitat Autònoma de Barcelona

Fecha:	2021
Resumen:	Bisphenol A (BPA) is a compound that is especially widespread in most commonly used objects due to its multiple uses in the plastic industry. However, several data support the need to restrict its use. In recent years, new implications of BPA on the renal system have been discovered, which denotes the need to expand studies in patients. To this end, a systematic review and a meta-analysis was performed to explore existing literature that examines the BPA-kidney disease paradigm and to determine what and how future studies will need to be carried out. Our systematic review revealed that only few relevant publications have focused on the problem. However, the subsequent meta-analysis revealed that high blood concentrations of BPA could be a factor in developing kidney disease, at least in people with previous pathologies such as diabetes or hypertension. Furthermore, BPA could also represent a risk factor in healthy people whose urinary excretion is higher. Finally, the data analyzed from the NHANES 03-16 cohort provided new evidence on the possible involvement of BPA in kidney disease. Therefore, our results underline the need to carry out a thorough and methodologically homogeneous study, delving into the relationship between urinary and blood BPA, glomerular filtration rate, and urine albumin-to-creatinine ratio, preferably in population groups at risk, and subsequently in the general population, to solve this relevant conundrum with critical potential implications in Public Health.
Ayudas:	Instituto de Salud Carlos III PI15/02139
Nota:	Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER); Comunidad Autónoma de Madrid (B2017-BMD-3686).
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Bisphenol A ; Kidney ; Systematic review ; Meta-analysis
Publicado en:	Biomolecules, Vol. 11 Núm. 7 (july 2021) , p. 1046, ISSN 2218-273X

DOI: 10.3390/biom11071046
PMID: 34356670

15 p, 3.5 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Recerca Sant Pau
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