Sex as a prognostic factor in systematic reviews : Challenges and lessons learned
Stallings, E. (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Antequera, Alba (Institut d'Investigació Biomèdica Sant Pau)
López-Alcalde, J. (Institute for Complementary and Integrative Medicine. University Hospital Zurich. University of Zurich)
García-Martín, M. (Universidad de Granada)
Urrútia, Gerard (Institut d'Investigació Biomèdica Sant Pau)
Zamora, Javier (University of Birmingham. Institute of Metabolism and Systems Researchs)

Date:	2021
Abstract:	Sex is a common baseline factor collected in studies that has the potential to be a prognostic factor (PF) in several clinical areas. In recent years, research on sex as a PF has increased; however, this influx of new studies frequently shows conflicting results across the same treatment or disease state. Thus, systematic reviews (SRs) addressing sex as a PF may help us to better understand diseases and further personalize healthcare. We wrote this article to offer insights into the challenges we encountered when conducting SRs on sex as a PF and suggestions on how to overcome these obstacles, regardless of the clinical domain. When carrying out a PF SR with sex as the index factor, it is important to keep in mind the modifications that must be made in various SR stages, such as modifying the PF section of CHARMS-PF, adjusting certain sections of QUIPS and extracting data on the sex and gender terms used throughout the studies. In this paper, we provide an overview of the lessons learned from carrying out our reviews on sex as a PF in different disciplines and now call on researchers, funding agencies and journals to realize the importance of studying sex as a PF.
Grants:	Instituto de Salud Carlos III PIE16/00050
Note:	Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Sex ; Gender ; Prognosis ; Prognostic factor ; Systematic review ; Methods
Published in:	Journal of personalized medicine, Vol. 11 Núm. 6 (2021) , p. 441, ISSN 2075-4426

DOI: 10.3390/jpm11060441
PMID: 34063786

9 p, 244.3 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles