SEOM Clinical Guideline of management of soft-tissue sarcoma (2020)
de Juan Ferre, Ana (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Alvarez, Rosa (Hospital General Universitario Gregorio Marañón)
Casado Herráez, Antonio (Hospital Universitario Clínico San Carlos (Madrid))
Cruz-Jurado, Josefina (Hospital Universitario de Canarias (La Laguna))
Estival, Anna (Institut Català d'Oncologia)
Martín-Broto, Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Martínez Marín, Virginia (Hospital Universitario La Paz (Madrid))
Moreno Vega, Alberto Luis (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Sebio, Ana (Institut d'Investigació Biomèdica Sant Pau)
Valverde Morales, Claudia (Hospital Universitari Vall d'Hebron)

Date:	2021
Abstract:	Soft-tissue sarcomas constitute an uncommon and heterogeneous group of tumors of mesenchymal origin. Diagnosis, treatment, and management should be performed by an expert multidisciplinary team. MRI/CT of the primary tumor and biopsy is mandatory before any treatment. Wide surgical resection with tumor-free tissue margin is the mainstay for localized disease. Radiotherapy is indicated in large, deep, high-grade tumors, or after marginal resection not suitable for re-excision. Perioperative chemotherapy should be discussed for high-risk sarcomas of the extremities and trunk-wall. In the case of oligometastatic disease, patients should be considered for local therapies. First-line treatment with anthracyclines (or in combination with ifosfamide) is the treatment of choice. Other drugs have shown activity in second-line therapy and in specific histological subtypes but options are limited and thus, a clinical trial should always be discussed.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Sarcoma ; Guidelines ; Soft-tissue tumors ; Uncommon tumors
Published in:	Clinical & translational oncology, Vol. 23 Núm. 5 (may 2021) , p. 922-930, ISSN 1699-3055

DOI: 10.1007/s12094-020-02534-0
PMID: 33405052

9 p, 838.3 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles